Functional variants of TSPAN8 are associated with bipolar disorder and schizophrenia

Tetraspanins affect protein trafficking and are known to influence a wide variety of physiologic processes. Recently, single nucleotide polymorphisms (SNPs) of the tetraspanin gene TSPAN8 were found among the best ranked markers of genome wide association studies on bipolar disorder (BPD) (rs1705236...

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Veröffentlicht in:	American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2010-06, Vol.153B (4), p.967-972
Hauptverfasser:	Scholz, Claus-Jürgen, Jacob, Christian P., Buttenschon, Henriette N., Kittel-Schneider, Sarah, Boreatti-Hümmer, Andrea, Zimmer, Michael, Walter, Ulrich, Lesch, Klaus-Peter, Mors, Ole, Kneitz, Susanne, Deckert, Jürgen, Reif, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Alleles Antigens, Neoplasm association Biological and medical sciences Bipolar disorder Bipolar Disorder - genetics Bipolar disorders Case-Control Studies Diabetes mellitus Gene mapping Genome-Wide Association Study Genomes GWAS haplotype Humans Interviews as Topic Medical genetics Medical sciences Membrane Glycoproteins Membrane Proteins Mental disorders Miscellaneous Mood disorders Multicenter Studies as Topic nsSNP Polymorphism, Genetic Polymorphism, Single Nucleotide Promoters Protein transport Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses replication Schizophrenia Schizophrenia - genetics Single-nucleotide polymorphism tetraspanin Tetraspanins Transcription factors
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