Mast cells in canine cutaneous hemangioma, hemangiosarcoma and mammary tumors
Mast cell count (MCC) in 45 dogs with cutaneous hemangioma (HA, n = 12), hemangiosarcoma (HSA, n = 12), mammary adenoma (AD, n = 9) and mammary adenocarcinoma (AC, n = 12) was made using Toluidine blue stained sections. Antibodies against endothelial cell markers, Factor VIII and VEGF were used to v...
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| Veröffentlicht in: | Veterinary research communications 2010-02, Vol.34 (2), p.153-160 |
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| description | Mast cell count (MCC) in 45 dogs with cutaneous hemangioma (HA, n = 12), hemangiosarcoma (HSA, n = 12), mammary adenoma (AD, n = 9) and mammary adenocarcinoma (AC, n = 12) was made using Toluidine blue stained sections. Antibodies against endothelial cell markers, Factor VIII and VEGF were used to visualize and determine the hot spot micro-vessel density (MVD). Total MCC and MCC along the invasive edges were significantly higher (p 0.05), in HSAs (8.6 ± 3.3) than in HAs (5.5 ± 2.8). There is a positive correlation (r = 0.14) between the hot spot MCC and MVD in mammary AC, although not significant (p = 0.3172), indicating that mast cells are associated with angiogenesis in canine mammary AC. This study suggests that mast cells may play an important role in neovascularization of canine cutaneous vascular and mammary neoplasms. Detailed studies encompassing correlation of MCC and MVD with clinical outcomes and prognosis in these neoplasms are recommended. |
| doi_str_mv | 10.1007/s11259-010-9341-1 |
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Antibodies against endothelial cell markers, Factor VIII and VEGF were used to visualize and determine the hot spot micro-vessel density (MVD). Total MCC and MCC along the invasive edges were significantly higher (p < 0.001) in canine mammary AC than in AD. The total MCC did not significantly differ (p > 0.05), in HSAs (8.6 ± 3.3) than in HAs (5.5 ± 2.8). There is a positive correlation (r = 0.14) between the hot spot MCC and MVD in mammary AC, although not significant (p = 0.3172), indicating that mast cells are associated with angiogenesis in canine mammary AC. This study suggests that mast cells may play an important role in neovascularization of canine cutaneous vascular and mammary neoplasms. Detailed studies encompassing correlation of MCC and MVD with clinical outcomes and prognosis in these neoplasms are recommended.</description><identifier>ISSN: 0165-7380</identifier><identifier>EISSN: 1573-7446</identifier><identifier>DOI: 10.1007/s11259-010-9341-1</identifier><identifier>PMID: 20127412</identifier><language>eng</language><publisher>Dordrecht: Dordrecht : Springer Netherlands</publisher><subject>Adenocarcinoma - blood supply ; Adenocarcinoma - pathology ; Adenocarcinoma - veterinary ; Adenoma - blood supply ; Adenoma - pathology ; Adenoma - veterinary ; angiogenesis ; Animals ; Biomedical and Life Sciences ; blood vessels ; Cell Count - veterinary ; dog diseases ; Dog Diseases - pathology ; Dogs ; Factor VIII - metabolism ; Female ; hemangioma ; Hemangioma - blood supply ; Hemangioma - pathology ; Hemangioma - veterinary ; hemangiosarcoma ; Hemangiosarcoma - blood supply ; Hemangiosarcoma - pathology ; Hemangiosarcoma - veterinary ; Immunohistochemistry - veterinary ; Life Sciences ; mammary neoplasms (animal) ; Mammary Neoplasms, Animal - blood supply ; Mammary Neoplasms, Animal - pathology ; mast cells ; Mast Cells - pathology ; Mastocytosis - blood supply ; Mastocytosis - pathology ; Mastocytosis - veterinary ; micro-vessel density ; Neovascularization, Pathologic - metabolism ; Neovascularization, Pathologic - pathology ; Neovascularization, Pathologic - veterinary ; Original Article ; skin ; Skin Neoplasms - blood supply ; Skin Neoplasms - pathology ; Skin Neoplasms - veterinary ; Vascular Endothelial Growth Factor A - metabolism ; Veterinary Medicine/Veterinary Science ; Zoology</subject><ispartof>Veterinary research communications, 2010-02, Vol.34 (2), p.153-160</ispartof><rights>Springer Science+Business Media B.V. 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c460t-8bfc6d881587124028ba9890f7f75b3341a9de440f6be63d44ca92639ddd7a1c3</citedby><cites>FETCH-LOGICAL-c460t-8bfc6d881587124028ba9890f7f75b3341a9de440f6be63d44ca92639ddd7a1c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11259-010-9341-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11259-010-9341-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20127412$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Woldemeskel, Moges</creatorcontrib><creatorcontrib>Rajeev, Sreekumari</creatorcontrib><title>Mast cells in canine cutaneous hemangioma, hemangiosarcoma and mammary tumors</title><title>Veterinary research communications</title><addtitle>Vet Res Commun</addtitle><addtitle>Vet Res Commun</addtitle><description>Mast cell count (MCC) in 45 dogs with cutaneous hemangioma (HA, n = 12), hemangiosarcoma (HSA, n = 12), mammary adenoma (AD, n = 9) and mammary adenocarcinoma (AC, n = 12) was made using Toluidine blue stained sections. Antibodies against endothelial cell markers, Factor VIII and VEGF were used to visualize and determine the hot spot micro-vessel density (MVD). Total MCC and MCC along the invasive edges were significantly higher (p < 0.001) in canine mammary AC than in AD. The total MCC did not significantly differ (p > 0.05), in HSAs (8.6 ± 3.3) than in HAs (5.5 ± 2.8). There is a positive correlation (r = 0.14) between the hot spot MCC and MVD in mammary AC, although not significant (p = 0.3172), indicating that mast cells are associated with angiogenesis in canine mammary AC. This study suggests that mast cells may play an important role in neovascularization of canine cutaneous vascular and mammary neoplasms. Detailed studies encompassing correlation of MCC and MVD with clinical outcomes and prognosis in these neoplasms are recommended.</description><subject>Adenocarcinoma - blood supply</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma - veterinary</subject><subject>Adenoma - blood supply</subject><subject>Adenoma - pathology</subject><subject>Adenoma - veterinary</subject><subject>angiogenesis</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>blood vessels</subject><subject>Cell Count - veterinary</subject><subject>dog diseases</subject><subject>Dog Diseases - pathology</subject><subject>Dogs</subject><subject>Factor VIII - metabolism</subject><subject>Female</subject><subject>hemangioma</subject><subject>Hemangioma - blood supply</subject><subject>Hemangioma - pathology</subject><subject>Hemangioma - veterinary</subject><subject>hemangiosarcoma</subject><subject>Hemangiosarcoma - blood supply</subject><subject>Hemangiosarcoma - pathology</subject><subject>Hemangiosarcoma - veterinary</subject><subject>Immunohistochemistry - veterinary</subject><subject>Life Sciences</subject><subject>mammary neoplasms (animal)</subject><subject>Mammary Neoplasms, Animal - blood supply</subject><subject>Mammary Neoplasms, Animal - pathology</subject><subject>mast cells</subject><subject>Mast Cells - pathology</subject><subject>Mastocytosis - blood supply</subject><subject>Mastocytosis - pathology</subject><subject>Mastocytosis - veterinary</subject><subject>micro-vessel density</subject><subject>Neovascularization, Pathologic - metabolism</subject><subject>Neovascularization, Pathologic - pathology</subject><subject>Neovascularization, Pathologic - veterinary</subject><subject>Original Article</subject><subject>skin</subject><subject>Skin Neoplasms - blood supply</subject><subject>Skin Neoplasms - pathology</subject><subject>Skin Neoplasms - veterinary</subject><subject>Vascular Endothelial Growth Factor A - metabolism</subject><subject>Veterinary Medicine/Veterinary Science</subject><subject>Zoology</subject><issn>0165-7380</issn><issn>1573-7446</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kEtPxCAUhYnROOPjB7jRxo0bq_cCLbA0xleicaGuCaV07GTajtAu_PfSVMfEhSsInHPuPR8hRwgXCCAuAyLNVAoIqWIcU9wic8wESwXn-TaZA-ZZKpiEGdkLYQkASgLbJTMKSAVHOidPTyb0iXWrVUjqNrGmrVuX2KE3reuGkLy7xrSLumvM-eYejLfxITFtmTSmaYz_TPqh6Xw4IDuVWQV3-H3uk7fbm9fr-_Tx-e7h-uoxtTyHPpVFZfNSSsykQMqBysIoqaASlcgKFqsYVTrOocoLl7OSc2sUzZkqy1IYtGyfnE25a999DC70uqnDWGLaWgvGEEZDVJ7-US67wbdxOR0JKEpBZlGEk8j6LgTvKr329VhLI-iRtJ5I60haj6Q1Rs_xd_BQNK7cOH7QRgGdBCF-tQvnfyf_l3oymSrTabPwddBvLzGSAUpEVDn7Amj3kQg</recordid><startdate>20100201</startdate><enddate>20100201</enddate><creator>Woldemeskel, Moges</creator><creator>Rajeev, Sreekumari</creator><general>Dordrecht : Springer Netherlands</general><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20100201</creationdate><title>Mast cells in canine cutaneous hemangioma, hemangiosarcoma and mammary tumors</title><author>Woldemeskel, Moges ; Rajeev, Sreekumari</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c460t-8bfc6d881587124028ba9890f7f75b3341a9de440f6be63d44ca92639ddd7a1c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adenocarcinoma - blood supply</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma - veterinary</topic><topic>Adenoma - blood supply</topic><topic>Adenoma - pathology</topic><topic>Adenoma - veterinary</topic><topic>angiogenesis</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>blood vessels</topic><topic>Cell Count - veterinary</topic><topic>dog diseases</topic><topic>Dog Diseases - pathology</topic><topic>Dogs</topic><topic>Factor VIII - metabolism</topic><topic>Female</topic><topic>hemangioma</topic><topic>Hemangioma - blood supply</topic><topic>Hemangioma - pathology</topic><topic>Hemangioma - veterinary</topic><topic>hemangiosarcoma</topic><topic>Hemangiosarcoma - blood supply</topic><topic>Hemangiosarcoma - pathology</topic><topic>Hemangiosarcoma - veterinary</topic><topic>Immunohistochemistry - veterinary</topic><topic>Life Sciences</topic><topic>mammary neoplasms (animal)</topic><topic>Mammary Neoplasms, Animal - blood supply</topic><topic>Mammary Neoplasms, Animal - pathology</topic><topic>mast cells</topic><topic>Mast Cells - pathology</topic><topic>Mastocytosis - blood supply</topic><topic>Mastocytosis - pathology</topic><topic>Mastocytosis - veterinary</topic><topic>micro-vessel density</topic><topic>Neovascularization, Pathologic - metabolism</topic><topic>Neovascularization, Pathologic - pathology</topic><topic>Neovascularization, Pathologic - veterinary</topic><topic>Original Article</topic><topic>skin</topic><topic>Skin Neoplasms - blood supply</topic><topic>Skin Neoplasms - pathology</topic><topic>Skin Neoplasms - veterinary</topic><topic>Vascular Endothelial Growth Factor A - metabolism</topic><topic>Veterinary Medicine/Veterinary Science</topic><topic>Zoology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Woldemeskel, Moges</creatorcontrib><creatorcontrib>Rajeev, Sreekumari</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Woldemeskel, Moges</au><au>Rajeev, Sreekumari</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mast cells in canine cutaneous hemangioma, hemangiosarcoma and mammary tumors</atitle><jtitle>Veterinary research communications</jtitle><stitle>Vet Res Commun</stitle><addtitle>Vet Res Commun</addtitle><date>2010-02-01</date><risdate>2010</risdate><volume>34</volume><issue>2</issue><spage>153</spage><epage>160</epage><pages>153-160</pages><issn>0165-7380</issn><eissn>1573-7446</eissn><abstract>Mast cell count (MCC) in 45 dogs with cutaneous hemangioma (HA, n = 12), hemangiosarcoma (HSA, n = 12), mammary adenoma (AD, n = 9) and mammary adenocarcinoma (AC, n = 12) was made using Toluidine blue stained sections. Antibodies against endothelial cell markers, Factor VIII and VEGF were used to visualize and determine the hot spot micro-vessel density (MVD). Total MCC and MCC along the invasive edges were significantly higher (p < 0.001) in canine mammary AC than in AD. The total MCC did not significantly differ (p > 0.05), in HSAs (8.6 ± 3.3) than in HAs (5.5 ± 2.8). There is a positive correlation (r = 0.14) between the hot spot MCC and MVD in mammary AC, although not significant (p = 0.3172), indicating that mast cells are associated with angiogenesis in canine mammary AC. This study suggests that mast cells may play an important role in neovascularization of canine cutaneous vascular and mammary neoplasms. Detailed studies encompassing correlation of MCC and MVD with clinical outcomes and prognosis in these neoplasms are recommended.</abstract><cop>Dordrecht</cop><pub>Dordrecht : Springer Netherlands</pub><pmid>20127412</pmid><doi>10.1007/s11259-010-9341-1</doi><tpages>8</tpages></addata></record> |
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| subjects | Adenocarcinoma - blood supply Adenocarcinoma - pathology Adenocarcinoma - veterinary Adenoma - blood supply Adenoma - pathology Adenoma - veterinary angiogenesis Animals Biomedical and Life Sciences blood vessels Cell Count - veterinary dog diseases Dog Diseases - pathology Dogs Factor VIII - metabolism Female hemangioma Hemangioma - blood supply Hemangioma - pathology Hemangioma - veterinary hemangiosarcoma Hemangiosarcoma - blood supply Hemangiosarcoma - pathology Hemangiosarcoma - veterinary Immunohistochemistry - veterinary Life Sciences mammary neoplasms (animal) Mammary Neoplasms, Animal - blood supply Mammary Neoplasms, Animal - pathology mast cells Mast Cells - pathology Mastocytosis - blood supply Mastocytosis - pathology Mastocytosis - veterinary micro-vessel density Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Neovascularization, Pathologic - veterinary Original Article skin Skin Neoplasms - blood supply Skin Neoplasms - pathology Skin Neoplasms - veterinary Vascular Endothelial Growth Factor A - metabolism Veterinary Medicine/Veterinary Science Zoology |
| title | Mast cells in canine cutaneous hemangioma, hemangiosarcoma and mammary tumors |
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