Mechanisms of pharmacokinetic drug-drug interactions

Pharmacokinetic drug-drug interactions occur when a drug alters the disposition (absorption, distribution, elimination) of a coadministered agent. Pharmacokinetic interactions may result in the increase or the decrease of plasma drug concentrations. These modifications are variable in intensity but...

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Veröffentlicht in:	La revue de medecine interne 2010-02, Vol.31 (2), p.170-179
Hauptverfasser:	Levêque, D, Lemachatti, J, Nivoix, Y, Coliat, P, Santucci, R, Ubeaud-Séquier, G, Beretz, L, Vinzio, S
Format:	Artikel
Sprache:	fre
Schlagworte:	Administration, Oral Anti-Infective Agents - therapeutic use Antineoplastic Agents - therapeutic use Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System - metabolism Drug Interactions Enzymes - genetics Erythromycin - pharmacokinetics Erythromycin - therapeutic use Humans Intestinal Absorption Kinetics Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism Orphan Nuclear Receptors - metabolism Pharmaceutical Preparations - metabolism Time Factors
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