Clinical Operational Tolerance After Solid Organ Transplantation
Abstract Clinical operational tolerance (COT) is a clinical condition obtainable with difficulty after solid organ transplantation (SOT). It is characterized by perfectly normal graft function in the total absence of maintenance immunosuppression. Major benefits deriving from the onset of COT are th...
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| Veröffentlicht in: | Transplantation proceedings 2009-05, Vol.41 (4), p.1278-1282 |
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| container_title | Transplantation proceedings |
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| creator | Di Cocco, P Bonanni, L D'Angelo, M Clemente, K Greco, S Rizza, V Mazzotta, C Scelzo, C Famulari, A Pisani, F Orlando, G |
| description | Abstract Clinical operational tolerance (COT) is a clinical condition obtainable with difficulty after solid organ transplantation (SOT). It is characterized by perfectly normal graft function in the total absence of maintenance immunosuppression. Major benefits deriving from the onset of COT are the reduction of risk for immunosuppression-related side effects and the improved quality of life. Currently, COT can be safely achieved in stable liver transplant recipients; it remains a challenge after renal transplantation. Only 1 case of COT has been reported after lung transplantation; no cases have been described after other types of SOT. Overall, mechanisms of COT are unclear and strategies to induce COT cannot be applied on a regular base to a large cohort of SOT recipients. Due to the failure of molecularly based tolerogenic protocols, great hope relies in the adoption of cell-based strategies. |
| doi_str_mv | 10.1016/j.transproceed.2009.03.003 |
| format | Article |
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It is characterized by perfectly normal graft function in the total absence of maintenance immunosuppression. Major benefits deriving from the onset of COT are the reduction of risk for immunosuppression-related side effects and the improved quality of life. Currently, COT can be safely achieved in stable liver transplant recipients; it remains a challenge after renal transplantation. Only 1 case of COT has been reported after lung transplantation; no cases have been described after other types of SOT. Overall, mechanisms of COT are unclear and strategies to induce COT cannot be applied on a regular base to a large cohort of SOT recipients. Due to the failure of molecularly based tolerogenic protocols, great hope relies in the adoption of cell-based strategies.</description><identifier>ISSN: 0041-1345</identifier><identifier>EISSN: 1873-2623</identifier><identifier>DOI: 10.1016/j.transproceed.2009.03.003</identifier><identifier>PMID: 19460538</identifier><identifier>CODEN: TRPPA8</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Biological and medical sciences ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Humans ; Immune Tolerance ; Immunosuppressive Agents - administration & dosage ; Immunosuppressive Agents - adverse effects ; Medical sciences ; Organ Transplantation ; Surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Tissue, organ and graft immunology</subject><ispartof>Transplantation proceedings, 2009-05, Vol.41 (4), p.1278-1282</ispartof><rights>Elsevier Inc.</rights><rights>2009 Elsevier Inc.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-b9b17395e6c1b422716f06817d8d3d7af373c0bd8d1c2a73f536f9ae395a548b3</citedby><cites>FETCH-LOGICAL-c464t-b9b17395e6c1b422716f06817d8d3d7af373c0bd8d1c2a73f536f9ae395a548b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.transproceed.2009.03.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,3550,23930,23931,25140,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21749726$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19460538$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Di Cocco, P</creatorcontrib><creatorcontrib>Bonanni, L</creatorcontrib><creatorcontrib>D'Angelo, M</creatorcontrib><creatorcontrib>Clemente, K</creatorcontrib><creatorcontrib>Greco, S</creatorcontrib><creatorcontrib>Rizza, V</creatorcontrib><creatorcontrib>Mazzotta, C</creatorcontrib><creatorcontrib>Scelzo, C</creatorcontrib><creatorcontrib>Famulari, A</creatorcontrib><creatorcontrib>Pisani, F</creatorcontrib><creatorcontrib>Orlando, G</creatorcontrib><title>Clinical Operational Tolerance After Solid Organ Transplantation</title><title>Transplantation proceedings</title><addtitle>Transplant Proc</addtitle><description>Abstract Clinical operational tolerance (COT) is a clinical condition obtainable with difficulty after solid organ transplantation (SOT). It is characterized by perfectly normal graft function in the total absence of maintenance immunosuppression. Major benefits deriving from the onset of COT are the reduction of risk for immunosuppression-related side effects and the improved quality of life. Currently, COT can be safely achieved in stable liver transplant recipients; it remains a challenge after renal transplantation. Only 1 case of COT has been reported after lung transplantation; no cases have been described after other types of SOT. Overall, mechanisms of COT are unclear and strategies to induce COT cannot be applied on a regular base to a large cohort of SOT recipients. Due to the failure of molecularly based tolerogenic protocols, great hope relies in the adoption of cell-based strategies.</description><subject>Biological and medical sciences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Immune Tolerance</subject><subject>Immunosuppressive Agents - administration & dosage</subject><subject>Immunosuppressive Agents - adverse effects</subject><subject>Medical sciences</subject><subject>Organ Transplantation</subject><subject>Surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Tissue, organ and graft immunology</subject><issn>0041-1345</issn><issn>1873-2623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUFv1DAQhS1ERZeWv4AiJMQpYexx7IQDolpaqFRpD92eLceZIC_ZZLGzSP33ON2oQpw42SO_NzP-HmPvOBQcuPq4K6Zgh3gIoyNqCwFQF4AFAL5gK15pzIUS-JKtACTPOcrynL2OcQepFhJfsXNeSwUlViv2Zd37wTvbZ5sDBTv5cUj37dinYnCUXXUThex-7H2bbcIPO2Tbp9m9HaYn9SU762wf6c1yXrCHm-vt-nt-t_l2u766y51UcsqbuuEa65KU440UQnPVgaq4bqsWW2071OigSRV3wmrsSlRdbSlZbCmrBi_Yh1Pf9O1fR4qT2fvoqE-L0HiMRiNygAp0Un46KV0YYwzUmUPwexseDQczAzQ78zdAMwM0gCYBTOa3y5hjs09vz9aFWBK8XwQ2JmzdjMnHZ53gWtZaqKT7etJRgvLbUzDReUpIWx_ITaYd_f_t8_mfNm4J7Cc9UtyNx5ACi4abKAyY-znyOXGok7uqEf8A2kqp5Q</recordid><startdate>20090501</startdate><enddate>20090501</enddate><creator>Di Cocco, P</creator><creator>Bonanni, L</creator><creator>D'Angelo, M</creator><creator>Clemente, K</creator><creator>Greco, S</creator><creator>Rizza, V</creator><creator>Mazzotta, C</creator><creator>Scelzo, C</creator><creator>Famulari, A</creator><creator>Pisani, F</creator><creator>Orlando, G</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090501</creationdate><title>Clinical Operational Tolerance After Solid Organ Transplantation</title><author>Di Cocco, P ; Bonanni, L ; D'Angelo, M ; Clemente, K ; Greco, S ; Rizza, V ; Mazzotta, C ; Scelzo, C ; Famulari, A ; Pisani, F ; Orlando, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-b9b17395e6c1b422716f06817d8d3d7af373c0bd8d1c2a73f536f9ae395a548b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Biological and medical sciences</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>Immune Tolerance</topic><topic>Immunosuppressive Agents - administration & dosage</topic><topic>Immunosuppressive Agents - adverse effects</topic><topic>Medical sciences</topic><topic>Organ Transplantation</topic><topic>Surgery</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Tissue, organ and graft immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Di Cocco, P</creatorcontrib><creatorcontrib>Bonanni, L</creatorcontrib><creatorcontrib>D'Angelo, M</creatorcontrib><creatorcontrib>Clemente, K</creatorcontrib><creatorcontrib>Greco, S</creatorcontrib><creatorcontrib>Rizza, V</creatorcontrib><creatorcontrib>Mazzotta, C</creatorcontrib><creatorcontrib>Scelzo, C</creatorcontrib><creatorcontrib>Famulari, A</creatorcontrib><creatorcontrib>Pisani, F</creatorcontrib><creatorcontrib>Orlando, G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Di Cocco, P</au><au>Bonanni, L</au><au>D'Angelo, M</au><au>Clemente, K</au><au>Greco, S</au><au>Rizza, V</au><au>Mazzotta, C</au><au>Scelzo, C</au><au>Famulari, A</au><au>Pisani, F</au><au>Orlando, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Operational Tolerance After Solid Organ Transplantation</atitle><jtitle>Transplantation proceedings</jtitle><addtitle>Transplant Proc</addtitle><date>2009-05-01</date><risdate>2009</risdate><volume>41</volume><issue>4</issue><spage>1278</spage><epage>1282</epage><pages>1278-1282</pages><issn>0041-1345</issn><eissn>1873-2623</eissn><coden>TRPPA8</coden><abstract>Abstract Clinical operational tolerance (COT) is a clinical condition obtainable with difficulty after solid organ transplantation (SOT). It is characterized by perfectly normal graft function in the total absence of maintenance immunosuppression. Major benefits deriving from the onset of COT are the reduction of risk for immunosuppression-related side effects and the improved quality of life. Currently, COT can be safely achieved in stable liver transplant recipients; it remains a challenge after renal transplantation. Only 1 case of COT has been reported after lung transplantation; no cases have been described after other types of SOT. Overall, mechanisms of COT are unclear and strategies to induce COT cannot be applied on a regular base to a large cohort of SOT recipients. Due to the failure of molecularly based tolerogenic protocols, great hope relies in the adoption of cell-based strategies.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>19460538</pmid><doi>10.1016/j.transproceed.2009.03.003</doi><tpages>5</tpages></addata></record> |
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| subjects | Biological and medical sciences Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immune Tolerance Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - adverse effects Medical sciences Organ Transplantation Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue, organ and graft immunology |
| title | Clinical Operational Tolerance After Solid Organ Transplantation |
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