Effects of Exercise in Volume Overload: Insights from a Model of Aortic Regurgitation
Aortic valve regurgitation (AR) imposes a pathologic volume overload to the left ventricle (LV), whereas aerobic exercise causes physiologic volume overloading. The impact of combining both LV volume overloads (pathologic and physiologic) is unknown. Considering the known beneficial effects of aerob...
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| Veröffentlicht in: | Medicine and science in sports and exercise 2009-06, Vol.41 (6), p.1230-1238 |
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| creator | LACHANCE, Dominic CHAMPETIER, Serge PLANTE, Eric BOUCHARD-THOMASSIN, Andrée-Anne ROUSSEL, Elise COUET, Jacques ARSENAULT, Marie |
| description | Aortic valve regurgitation (AR) imposes a pathologic volume overload to the left ventricle (LV), whereas aerobic exercise causes physiologic volume overloading. The impact of combining both LV volume overloads (pathologic and physiologic) is unknown. Considering the known beneficial effects of aerobic training on the cardiovascular system, we hypothesized that the positive effects would outweigh the negative ones and that exercise would improve the tolerance of the LV to AR.
Forty female adult Wistar rats were randomly divided in the following groups: 1) sham sedentary (SS), 2) sham trained (ST), 3) AR sedentary (ARS), and 4) AR trained (ART). Training consisted in treadmill running for 30 min five times per week at 20 m x s(-1) for 24 wk. In vivo follow-up was made by echocardiography and invasive intracardiac pressure measurements. Hearts were harvested for tissue analysis.
Echocardiography revealed less LV dilation and hypertrophy in ART versus ARS as well as improved myocardial performance index. LV ejection fractions remained similar and within normal range in ART versus ARS. Invasive cardiac pressures yielded improved dP/dt- in ART versus ARS but similar dP/dt+. beta(1)-Adrenergic receptor mRNA expression was improved in the ART group versus ARS.
Our data suggest that a moderate aerobic exercise program helps minimize LV dilation and hypertrophy and improves diastolic cardiac performance in heart submitted to chronic volume overload due to severe aortic valve regurgitation in this animal model. |
| doi_str_mv | 10.1249/MSS.0b013e318195b938 |
| format | Article |
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Forty female adult Wistar rats were randomly divided in the following groups: 1) sham sedentary (SS), 2) sham trained (ST), 3) AR sedentary (ARS), and 4) AR trained (ART). Training consisted in treadmill running for 30 min five times per week at 20 m x s(-1) for 24 wk. In vivo follow-up was made by echocardiography and invasive intracardiac pressure measurements. Hearts were harvested for tissue analysis.
Echocardiography revealed less LV dilation and hypertrophy in ART versus ARS as well as improved myocardial performance index. LV ejection fractions remained similar and within normal range in ART versus ARS. Invasive cardiac pressures yielded improved dP/dt- in ART versus ARS but similar dP/dt+. beta(1)-Adrenergic receptor mRNA expression was improved in the ART group versus ARS.
Our data suggest that a moderate aerobic exercise program helps minimize LV dilation and hypertrophy and improves diastolic cardiac performance in heart submitted to chronic volume overload due to severe aortic valve regurgitation in this animal model.</description><identifier>ISSN: 0195-9131</identifier><identifier>EISSN: 1530-0315</identifier><identifier>DOI: 10.1249/MSS.0b013e318195b938</identifier><identifier>PMID: 19461544</identifier><identifier>CODEN: MSPEDA</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Animals ; Aortic Valve Insufficiency - diagnostic imaging ; Aortic Valve Insufficiency - physiopathology ; Aortic Valve Insufficiency - prevention & control ; Biological and medical sciences ; Cardiomyopathy, Hypertrophic - diagnostic imaging ; Cardiomyopathy, Hypertrophic - physiopathology ; Cardiomyopathy, Hypertrophic - prevention & control ; Disease Models, Animal ; Exercise Tolerance ; Female ; Fundamental and applied biological sciences. Psychology ; Hemodynamics ; Hypertrophy, Left Ventricular - diagnostic imaging ; Hypertrophy, Left Ventricular - physiopathology ; Hypertrophy, Left Ventricular - prevention & control ; Rats ; Space life sciences ; Ultrasonography ; Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports</subject><ispartof>Medicine and science in sports and exercise, 2009-06, Vol.41 (6), p.1230-1238</ispartof><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c285t-b4f4b9ea28b4b20adfc8f787b7d0895583165dc970424e615ef9bfe9c45d9c8b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21510407$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19461544$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LACHANCE, Dominic</creatorcontrib><creatorcontrib>CHAMPETIER, Serge</creatorcontrib><creatorcontrib>PLANTE, Eric</creatorcontrib><creatorcontrib>BOUCHARD-THOMASSIN, Andrée-Anne</creatorcontrib><creatorcontrib>ROUSSEL, Elise</creatorcontrib><creatorcontrib>COUET, Jacques</creatorcontrib><creatorcontrib>ARSENAULT, Marie</creatorcontrib><title>Effects of Exercise in Volume Overload: Insights from a Model of Aortic Regurgitation</title><title>Medicine and science in sports and exercise</title><addtitle>Med Sci Sports Exerc</addtitle><description>Aortic valve regurgitation (AR) imposes a pathologic volume overload to the left ventricle (LV), whereas aerobic exercise causes physiologic volume overloading. The impact of combining both LV volume overloads (pathologic and physiologic) is unknown. Considering the known beneficial effects of aerobic training on the cardiovascular system, we hypothesized that the positive effects would outweigh the negative ones and that exercise would improve the tolerance of the LV to AR.
Forty female adult Wistar rats were randomly divided in the following groups: 1) sham sedentary (SS), 2) sham trained (ST), 3) AR sedentary (ARS), and 4) AR trained (ART). Training consisted in treadmill running for 30 min five times per week at 20 m x s(-1) for 24 wk. In vivo follow-up was made by echocardiography and invasive intracardiac pressure measurements. Hearts were harvested for tissue analysis.
Echocardiography revealed less LV dilation and hypertrophy in ART versus ARS as well as improved myocardial performance index. LV ejection fractions remained similar and within normal range in ART versus ARS. Invasive cardiac pressures yielded improved dP/dt- in ART versus ARS but similar dP/dt+. beta(1)-Adrenergic receptor mRNA expression was improved in the ART group versus ARS.
Our data suggest that a moderate aerobic exercise program helps minimize LV dilation and hypertrophy and improves diastolic cardiac performance in heart submitted to chronic volume overload due to severe aortic valve regurgitation in this animal model.</description><subject>Animals</subject><subject>Aortic Valve Insufficiency - diagnostic imaging</subject><subject>Aortic Valve Insufficiency - physiopathology</subject><subject>Aortic Valve Insufficiency - prevention & control</subject><subject>Biological and medical sciences</subject><subject>Cardiomyopathy, Hypertrophic - diagnostic imaging</subject><subject>Cardiomyopathy, Hypertrophic - physiopathology</subject><subject>Cardiomyopathy, Hypertrophic - prevention & control</subject><subject>Disease Models, Animal</subject><subject>Exercise Tolerance</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hemodynamics</subject><subject>Hypertrophy, Left Ventricular - diagnostic imaging</subject><subject>Hypertrophy, Left Ventricular - physiopathology</subject><subject>Hypertrophy, Left Ventricular - prevention & control</subject><subject>Rats</subject><subject>Space life sciences</subject><subject>Ultrasonography</subject><subject>Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. 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Psychology</topic><topic>Hemodynamics</topic><topic>Hypertrophy, Left Ventricular - diagnostic imaging</topic><topic>Hypertrophy, Left Ventricular - physiopathology</topic><topic>Hypertrophy, Left Ventricular - prevention & control</topic><topic>Rats</topic><topic>Space life sciences</topic><topic>Ultrasonography</topic><topic>Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LACHANCE, Dominic</creatorcontrib><creatorcontrib>CHAMPETIER, Serge</creatorcontrib><creatorcontrib>PLANTE, Eric</creatorcontrib><creatorcontrib>BOUCHARD-THOMASSIN, Andrée-Anne</creatorcontrib><creatorcontrib>ROUSSEL, Elise</creatorcontrib><creatorcontrib>COUET, Jacques</creatorcontrib><creatorcontrib>ARSENAULT, Marie</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Medicine and science in sports and exercise</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LACHANCE, Dominic</au><au>CHAMPETIER, Serge</au><au>PLANTE, Eric</au><au>BOUCHARD-THOMASSIN, Andrée-Anne</au><au>ROUSSEL, Elise</au><au>COUET, Jacques</au><au>ARSENAULT, Marie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Exercise in Volume Overload: Insights from a Model of Aortic Regurgitation</atitle><jtitle>Medicine and science in sports and exercise</jtitle><addtitle>Med Sci Sports Exerc</addtitle><date>2009-06-01</date><risdate>2009</risdate><volume>41</volume><issue>6</issue><spage>1230</spage><epage>1238</epage><pages>1230-1238</pages><issn>0195-9131</issn><eissn>1530-0315</eissn><coden>MSPEDA</coden><abstract>Aortic valve regurgitation (AR) imposes a pathologic volume overload to the left ventricle (LV), whereas aerobic exercise causes physiologic volume overloading. The impact of combining both LV volume overloads (pathologic and physiologic) is unknown. Considering the known beneficial effects of aerobic training on the cardiovascular system, we hypothesized that the positive effects would outweigh the negative ones and that exercise would improve the tolerance of the LV to AR.
Forty female adult Wistar rats were randomly divided in the following groups: 1) sham sedentary (SS), 2) sham trained (ST), 3) AR sedentary (ARS), and 4) AR trained (ART). Training consisted in treadmill running for 30 min five times per week at 20 m x s(-1) for 24 wk. In vivo follow-up was made by echocardiography and invasive intracardiac pressure measurements. Hearts were harvested for tissue analysis.
Echocardiography revealed less LV dilation and hypertrophy in ART versus ARS as well as improved myocardial performance index. LV ejection fractions remained similar and within normal range in ART versus ARS. Invasive cardiac pressures yielded improved dP/dt- in ART versus ARS but similar dP/dt+. beta(1)-Adrenergic receptor mRNA expression was improved in the ART group versus ARS.
Our data suggest that a moderate aerobic exercise program helps minimize LV dilation and hypertrophy and improves diastolic cardiac performance in heart submitted to chronic volume overload due to severe aortic valve regurgitation in this animal model.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>19461544</pmid><doi>10.1249/MSS.0b013e318195b938</doi><tpages>9</tpages></addata></record> |
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| subjects | Animals Aortic Valve Insufficiency - diagnostic imaging Aortic Valve Insufficiency - physiopathology Aortic Valve Insufficiency - prevention & control Biological and medical sciences Cardiomyopathy, Hypertrophic - diagnostic imaging Cardiomyopathy, Hypertrophic - physiopathology Cardiomyopathy, Hypertrophic - prevention & control Disease Models, Animal Exercise Tolerance Female Fundamental and applied biological sciences. Psychology Hemodynamics Hypertrophy, Left Ventricular - diagnostic imaging Hypertrophy, Left Ventricular - physiopathology Hypertrophy, Left Ventricular - prevention & control Rats Space life sciences Ultrasonography Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports |
| title | Effects of Exercise in Volume Overload: Insights from a Model of Aortic Regurgitation |
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