Heterogeneous arterial healing in patients following paclitaxel-eluting stent implantation: comparison with sirolimus-eluting stents
We angioscopically compared paclitaxel-eluting stents (PES) and sirolimus-eluting stents (SES) to explore differences in arterial healing. Drug-eluting stents may demonstrate different arterial healing processes. Angioscopy was performed 9 +/- 2 months after 30 PES and 36 SES were implanted initiall...
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| Veröffentlicht in: | JACC. Cardiovascular interventions 2009-05, Vol.2 (5), p.453-458 |
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| container_title | JACC. Cardiovascular interventions |
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| creator | Awata, Masaki Nanto, Shinsuke Uematsu, Masaaki Morozumi, Takakazu Watanabe, Tetsuya Onishi, Toshinari Iida, Osamu Sera, Fusako Minamiguchi, Hitoshi Kotani, Jun-ichi Nagata, Seiki |
| description | We angioscopically compared paclitaxel-eluting stents (PES) and sirolimus-eluting stents (SES) to explore differences in arterial healing.
Drug-eluting stents may demonstrate different arterial healing processes.
Angioscopy was performed 9 +/- 2 months after 30 PES and 36 SES were implanted initially in the native coronary artery. Heterogeneity of the neointimal coverage (NIC) as well as the dominant grade was examined. Neointimal coverage was defined as follows: grade 0 = fully visible struts; grade 1 = struts bulged into the lumen, but covered; grade 2 = embedded, but translucent struts; grade 3 = invisible struts. Heterogeneity was judged when the NIC grade variation >or=1. Thrombi and yellow plaques (YP) were also explored.
In-stent late loss (0.44 +/- 0.44 mm vs. 0.13 +/- 0.33 mm; p < 0.0001) and dominant NIC grade (1.8 +/- 1.1 vs. 1.3 +/- 0.7; p = 0.02) were greater in PES than in SES. Of PES, 48% showed the heterogeneity of 1 grade; 26% showed that of 2 grades. Of SES, 53% showed homogeneous coverage; the remaining SES showed the heterogeneity of 1 grade; and 72% showed dominant grade 1. Thrombi were more common in PES than in SES (43% vs. 19%; p = 0.04). Both stents commonly revealed YP (83% vs. 78%; p = 0.76).
NIC was more heterogeneous in PES, associated with a higher incidence of thrombi. Homogeneous NIC may be an important factor for competent arterial healing. |
| doi_str_mv | 10.1016/j.jcin.2009.03.005 |
| format | Article |
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Drug-eluting stents may demonstrate different arterial healing processes.
Angioscopy was performed 9 +/- 2 months after 30 PES and 36 SES were implanted initially in the native coronary artery. Heterogeneity of the neointimal coverage (NIC) as well as the dominant grade was examined. Neointimal coverage was defined as follows: grade 0 = fully visible struts; grade 1 = struts bulged into the lumen, but covered; grade 2 = embedded, but translucent struts; grade 3 = invisible struts. Heterogeneity was judged when the NIC grade variation >or=1. Thrombi and yellow plaques (YP) were also explored.
In-stent late loss (0.44 +/- 0.44 mm vs. 0.13 +/- 0.33 mm; p < 0.0001) and dominant NIC grade (1.8 +/- 1.1 vs. 1.3 +/- 0.7; p = 0.02) were greater in PES than in SES. Of PES, 48% showed the heterogeneity of 1 grade; 26% showed that of 2 grades. Of SES, 53% showed homogeneous coverage; the remaining SES showed the heterogeneity of 1 grade; and 72% showed dominant grade 1. Thrombi were more common in PES than in SES (43% vs. 19%; p = 0.04). Both stents commonly revealed YP (83% vs. 78%; p = 0.76).
NIC was more heterogeneous in PES, associated with a higher incidence of thrombi. Homogeneous NIC may be an important factor for competent arterial healing.</description><identifier>EISSN: 1876-7605</identifier><identifier>DOI: 10.1016/j.jcin.2009.03.005</identifier><identifier>PMID: 19463470</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Antineoplastic Agents, Phytogenic - therapeutic use ; Aspirin - therapeutic use ; Coronary Angiography ; Coronary Artery Disease - drug therapy ; Coronary Artery Disease - pathology ; Coronary Restenosis ; Coronary Vessels - drug effects ; Coronary Vessels - pathology ; Drug-Eluting Stents ; Endothelium, Vascular - drug effects ; Endothelium, Vascular - pathology ; Female ; Humans ; Male ; Middle Aged ; Paclitaxel - therapeutic use ; Platelet Aggregation Inhibitors - therapeutic use ; Retrospective Studies ; Ticlopidine - therapeutic use</subject><ispartof>JACC. Cardiovascular interventions, 2009-05, Vol.2 (5), p.453-458</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19463470$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Awata, Masaki</creatorcontrib><creatorcontrib>Nanto, Shinsuke</creatorcontrib><creatorcontrib>Uematsu, Masaaki</creatorcontrib><creatorcontrib>Morozumi, Takakazu</creatorcontrib><creatorcontrib>Watanabe, Tetsuya</creatorcontrib><creatorcontrib>Onishi, Toshinari</creatorcontrib><creatorcontrib>Iida, Osamu</creatorcontrib><creatorcontrib>Sera, Fusako</creatorcontrib><creatorcontrib>Minamiguchi, Hitoshi</creatorcontrib><creatorcontrib>Kotani, Jun-ichi</creatorcontrib><creatorcontrib>Nagata, Seiki</creatorcontrib><title>Heterogeneous arterial healing in patients following paclitaxel-eluting stent implantation: comparison with sirolimus-eluting stents</title><title>JACC. Cardiovascular interventions</title><addtitle>JACC Cardiovasc Interv</addtitle><description>We angioscopically compared paclitaxel-eluting stents (PES) and sirolimus-eluting stents (SES) to explore differences in arterial healing.
Drug-eluting stents may demonstrate different arterial healing processes.
Angioscopy was performed 9 +/- 2 months after 30 PES and 36 SES were implanted initially in the native coronary artery. Heterogeneity of the neointimal coverage (NIC) as well as the dominant grade was examined. Neointimal coverage was defined as follows: grade 0 = fully visible struts; grade 1 = struts bulged into the lumen, but covered; grade 2 = embedded, but translucent struts; grade 3 = invisible struts. Heterogeneity was judged when the NIC grade variation >or=1. Thrombi and yellow plaques (YP) were also explored.
In-stent late loss (0.44 +/- 0.44 mm vs. 0.13 +/- 0.33 mm; p < 0.0001) and dominant NIC grade (1.8 +/- 1.1 vs. 1.3 +/- 0.7; p = 0.02) were greater in PES than in SES. Of PES, 48% showed the heterogeneity of 1 grade; 26% showed that of 2 grades. Of SES, 53% showed homogeneous coverage; the remaining SES showed the heterogeneity of 1 grade; and 72% showed dominant grade 1. Thrombi were more common in PES than in SES (43% vs. 19%; p = 0.04). Both stents commonly revealed YP (83% vs. 78%; p = 0.76).
NIC was more heterogeneous in PES, associated with a higher incidence of thrombi. Homogeneous NIC may be an important factor for competent arterial healing.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antineoplastic Agents, Phytogenic - therapeutic use</subject><subject>Aspirin - therapeutic use</subject><subject>Coronary Angiography</subject><subject>Coronary Artery Disease - drug therapy</subject><subject>Coronary Artery Disease - pathology</subject><subject>Coronary Restenosis</subject><subject>Coronary Vessels - drug effects</subject><subject>Coronary Vessels - pathology</subject><subject>Drug-Eluting Stents</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Endothelium, Vascular - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Paclitaxel - therapeutic use</subject><subject>Platelet Aggregation Inhibitors - therapeutic use</subject><subject>Retrospective Studies</subject><subject>Ticlopidine - therapeutic use</subject><issn>1876-7605</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkDFPwzAQhS0kREvhDzAgb0wJ5zhxGjZUUYpUiQXmyLUvrSvHDrGjws4PJxVlYDrde9873R0hNwxSBkzc79O9Mi7NAKoUeApQnJEpm5ciKQUUE3IZwh5AQFVmF2TCqlzwvIQp-V5hxN5v0aEfApX92Blp6Q6lNW5LjaOdjAZdDLTx1vrDUe2ksibKT7QJ2iEepRBHhpq2s9LFMeHdA1W-7WRvgnf0YOKOBtN7a9oh_E-FK3LeSBvw-lRn5H359LZYJevX55fF4zrZZXkVEy5EMW-0LjgwroumqrTUUDI5upkSfPTLnKPiucJMFgoV4AY1Z5oBR5nxGbn7ndv1_mPAEOvWBIV2XPl4fV1yzgCynI3k7YkcNi3quutNK_uv-u9x_Acz03Ox</recordid><startdate>200905</startdate><enddate>200905</enddate><creator>Awata, Masaki</creator><creator>Nanto, Shinsuke</creator><creator>Uematsu, Masaaki</creator><creator>Morozumi, Takakazu</creator><creator>Watanabe, Tetsuya</creator><creator>Onishi, Toshinari</creator><creator>Iida, Osamu</creator><creator>Sera, Fusako</creator><creator>Minamiguchi, Hitoshi</creator><creator>Kotani, Jun-ichi</creator><creator>Nagata, Seiki</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200905</creationdate><title>Heterogeneous arterial healing in patients following paclitaxel-eluting stent implantation: comparison with sirolimus-eluting stents</title><author>Awata, Masaki ; Nanto, Shinsuke ; Uematsu, Masaaki ; Morozumi, Takakazu ; Watanabe, Tetsuya ; Onishi, Toshinari ; Iida, Osamu ; Sera, Fusako ; Minamiguchi, Hitoshi ; Kotani, Jun-ichi ; Nagata, Seiki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h249t-36658fdd53013d5f99dad071a2492c63366743ec34ce2a5cec0ebed31d103ea23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antineoplastic Agents, Phytogenic - therapeutic use</topic><topic>Aspirin - therapeutic use</topic><topic>Coronary Angiography</topic><topic>Coronary Artery Disease - drug therapy</topic><topic>Coronary Artery Disease - pathology</topic><topic>Coronary Restenosis</topic><topic>Coronary Vessels - drug effects</topic><topic>Coronary Vessels - pathology</topic><topic>Drug-Eluting Stents</topic><topic>Endothelium, Vascular - drug effects</topic><topic>Endothelium, Vascular - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Paclitaxel - therapeutic use</topic><topic>Platelet Aggregation Inhibitors - therapeutic use</topic><topic>Retrospective Studies</topic><topic>Ticlopidine - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Awata, Masaki</creatorcontrib><creatorcontrib>Nanto, Shinsuke</creatorcontrib><creatorcontrib>Uematsu, Masaaki</creatorcontrib><creatorcontrib>Morozumi, Takakazu</creatorcontrib><creatorcontrib>Watanabe, Tetsuya</creatorcontrib><creatorcontrib>Onishi, Toshinari</creatorcontrib><creatorcontrib>Iida, Osamu</creatorcontrib><creatorcontrib>Sera, Fusako</creatorcontrib><creatorcontrib>Minamiguchi, Hitoshi</creatorcontrib><creatorcontrib>Kotani, Jun-ichi</creatorcontrib><creatorcontrib>Nagata, Seiki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>JACC. Cardiovascular interventions</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Awata, Masaki</au><au>Nanto, Shinsuke</au><au>Uematsu, Masaaki</au><au>Morozumi, Takakazu</au><au>Watanabe, Tetsuya</au><au>Onishi, Toshinari</au><au>Iida, Osamu</au><au>Sera, Fusako</au><au>Minamiguchi, Hitoshi</au><au>Kotani, Jun-ichi</au><au>Nagata, Seiki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heterogeneous arterial healing in patients following paclitaxel-eluting stent implantation: comparison with sirolimus-eluting stents</atitle><jtitle>JACC. Cardiovascular interventions</jtitle><addtitle>JACC Cardiovasc Interv</addtitle><date>2009-05</date><risdate>2009</risdate><volume>2</volume><issue>5</issue><spage>453</spage><epage>458</epage><pages>453-458</pages><eissn>1876-7605</eissn><abstract>We angioscopically compared paclitaxel-eluting stents (PES) and sirolimus-eluting stents (SES) to explore differences in arterial healing.
Drug-eluting stents may demonstrate different arterial healing processes.
Angioscopy was performed 9 +/- 2 months after 30 PES and 36 SES were implanted initially in the native coronary artery. Heterogeneity of the neointimal coverage (NIC) as well as the dominant grade was examined. Neointimal coverage was defined as follows: grade 0 = fully visible struts; grade 1 = struts bulged into the lumen, but covered; grade 2 = embedded, but translucent struts; grade 3 = invisible struts. Heterogeneity was judged when the NIC grade variation >or=1. Thrombi and yellow plaques (YP) were also explored.
In-stent late loss (0.44 +/- 0.44 mm vs. 0.13 +/- 0.33 mm; p < 0.0001) and dominant NIC grade (1.8 +/- 1.1 vs. 1.3 +/- 0.7; p = 0.02) were greater in PES than in SES. Of PES, 48% showed the heterogeneity of 1 grade; 26% showed that of 2 grades. Of SES, 53% showed homogeneous coverage; the remaining SES showed the heterogeneity of 1 grade; and 72% showed dominant grade 1. Thrombi were more common in PES than in SES (43% vs. 19%; p = 0.04). Both stents commonly revealed YP (83% vs. 78%; p = 0.76).
NIC was more heterogeneous in PES, associated with a higher incidence of thrombi. Homogeneous NIC may be an important factor for competent arterial healing.</abstract><cop>United States</cop><pmid>19463470</pmid><doi>10.1016/j.jcin.2009.03.005</doi><tpages>6</tpages></addata></record> |
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| ispartof | JACC. Cardiovascular interventions, 2009-05, Vol.2 (5), p.453-458 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present); EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Aged, 80 and over Antineoplastic Agents, Phytogenic - therapeutic use Aspirin - therapeutic use Coronary Angiography Coronary Artery Disease - drug therapy Coronary Artery Disease - pathology Coronary Restenosis Coronary Vessels - drug effects Coronary Vessels - pathology Drug-Eluting Stents Endothelium, Vascular - drug effects Endothelium, Vascular - pathology Female Humans Male Middle Aged Paclitaxel - therapeutic use Platelet Aggregation Inhibitors - therapeutic use Retrospective Studies Ticlopidine - therapeutic use |
| title | Heterogeneous arterial healing in patients following paclitaxel-eluting stent implantation: comparison with sirolimus-eluting stents |
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