FXYD7, the first brain- and isoform-specific regulator of Na,K-ATPase: biosynthesis and function of its posttranslational modifications

The FXYD protein family has recently been defined as a result of the search for homologues of the Na,K-ATPase gamma subunit, CHIF, and phospholemman in EST and gene data banks. FXYD7 has been seen to have a role as a brain- and isozyme-specific regulator of Na/K-ATPase. In this study, the biosynthes...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2003-04, Vol.986 (1), p.444-448
Hauptverfasser:	Crambert, Gilles, Béguin, Pascal, Uldry, Marc, Monnet-Tschudi, Florianne, Horisberger, Jean-Daniel, Garty, Haim, Geering, Käthi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - metabolism Kinetics Membrane Glycoproteins - metabolism Nerve Tissue Proteins - metabolism Protein Isoforms - metabolism Protein Processing, Post-Translational Sodium-Potassium-Exchanging ATPase - biosynthesis
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Beschreibung
Zusammenfassung:	The FXYD protein family has recently been defined as a result of the search for homologues of the Na,K-ATPase gamma subunit, CHIF, and phospholemman in EST and gene data banks. FXYD7 has been seen to have a role as a brain- and isozyme-specific regulator of Na/K-ATPase. In this study, the biosynthesis, membrane topology, nature, and role of the processing of FXYD7 are investigated.
ISSN:	0077-8923 1749-6632
DOI:	10.1111/j.1749-6632.2003.tb07227.x