Prevention of embryo loss in non-obese diabetic mice using adoptive ITGA2+ISG20+ natural killer-cell transfer

Both regulatory T cells and regulatory natural killer (NK) cells may play essential roles in the maintenance of pregnancy. In this study, we show that a significantly high percentage of spontaneous embryo loss was observed in both allogeneic and syngeneic pregnant non-obese diabetic (NOD) mice. The...

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Veröffentlicht in:	Reproduction (Cambridge, England) England), 2009-06, Vol.137 (6), p.943-955
Hauptverfasser:	Lin, Yi, Wang, Huiqi, Wang, Wenjing, Zeng, Shan, Zhong, Yanmin, Li, Da-Jin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Cells, Cultured Chemotaxis, Leukocyte Diabetes Complications - immunology Diabetes Complications - prevention & control Disease Models, Animal Embryo Loss - immunology Embryo Loss - prevention & control Female Forkhead Transcription Factors - metabolism G(M1) Ganglioside - immunology Immune Tolerance Integrin alpha2 - metabolism Interleukin-2 Receptor alpha Subunit - metabolism Killer Cells, Natural - immunology Killer Cells, Natural - transplantation Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred NOD Placenta - immunology Pregnancy Receptors, CXCR4 - metabolism Transplantation, Homologous Transplantation, Isogeneic
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