Clinical meaning of pepsinogen test and Helicobacter pylori serology in the health check-up population in Korea

OBJECTIVEThis study was performed to assess the affects of age, sex, and Helicobacter pylori status on pepsinogen testing for atrophic gastritis and to establish the clinical implications of pepsinogen test results and H. pylori serology in a Korean population presenting for a health check-up. METHO...

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Veröffentlicht in:European journal of gastroenterology & hepatology 2009-06, Vol.21 (6), p.606-612
Hauptverfasser: Kim, Hyun Young, Kim, Nayoung, Kang, Jung Mook, Park, Young Soo, Lee, Dong Ho, Kim, Yu Rim, Kim, Joo Sung, Jung, Hyun Chae, Song, In Sung
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container_end_page 612
container_issue 6
container_start_page 606
container_title European journal of gastroenterology & hepatology
container_volume 21
creator Kim, Hyun Young
Kim, Nayoung
Kang, Jung Mook
Park, Young Soo
Lee, Dong Ho
Kim, Yu Rim
Kim, Joo Sung
Jung, Hyun Chae
Song, In Sung
description OBJECTIVEThis study was performed to assess the affects of age, sex, and Helicobacter pylori status on pepsinogen testing for atrophic gastritis and to establish the clinical implications of pepsinogen test results and H. pylori serology in a Korean population presenting for a health check-up. METHODSSerum pepsinogen (PG) I and PG II, and H. pylori IgG were measured in 1485 adults. The PG values were analyzed based on age, sex, and H. pylori status, and the cutoff value for atrophic gastritis was determined. RESULTSSerum PG I (sPGI) and sPGII were higher in H. pylori positive than in H. pylori negative individuals (sPGI, 56.3 vs. 42.2 μg/l, P
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METHODSSerum pepsinogen (PG) I and PG II, and H. pylori IgG were measured in 1485 adults. The PG values were analyzed based on age, sex, and H. pylori status, and the cutoff value for atrophic gastritis was determined. RESULTSSerum PG I (sPGI) and sPGII were higher in H. pylori positive than in H. pylori negative individuals (sPGI, 56.3 vs. 42.2 μg/l, P<0.001; sPGII, 17.5 vs. 8.0 μg/l, P<0.001). The PG I/II ratio was lower in H. pylori positive than in H. pylori negative individuals (3.7 vs. 6.0, P<0.001). The sPGII and PG I/II ratio had a positive (r=0.132, P<0.001) and negative correlation with age (r=−0.229, P<0.001), respectively. Men had a higher sPGI (54.7 μg/l) than did women (48.4 μg/l) (P<0.001) but the PG I/II ratio was not statistically different and neither the atrophic gastritis. The PG I/II cutoff value for atrophic gastritis was 6.0 for H. pylori negative and 3.0 for H. pylori positive individuals. sPGI and sPGII were, however, not specific for atrophic gastritis. CONCLUSIONThe H. pylori IgG status, age, and sex were associated with the serum PG levels. To increase the efficacy of the PG I/II ratio for the detection of atrophic gastritis, the cutoff value of the PG I/II ratio should be stratified according to the H. pylori IgG status in the Korean population presenting for a health check-up.]]></description><identifier>ISSN: 0954-691X</identifier><identifier>EISSN: 1473-5687</identifier><identifier>DOI: 10.1097/MEG.0b013e3283086757</identifier><identifier>PMID: 19293719</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams &amp; Wilkins, Inc</publisher><subject>Adolescent ; Adult ; Age Distribution ; Age Factors ; Aged ; Aged, 80 and over ; Antibodies, Bacterial - blood ; Bacterial diseases ; Bacterial diseases of the digestive system and abdomen ; Biological and medical sciences ; Biomarkers - blood ; Clinical Enzyme Tests - methods ; Female ; Gastritis, Atrophic - diagnosis ; Gastritis, Atrophic - microbiology ; Gastroenterology. Liver. Pancreas. Abdomen ; Helicobacter Infections - complications ; Helicobacter Infections - enzymology ; Helicobacter pylori - immunology ; Helicobacter pylori - isolation &amp; purification ; Human bacterial diseases ; Humans ; Immunoglobulin G - blood ; Infectious diseases ; Male ; Mass Screening - methods ; Medical sciences ; Middle Aged ; Other diseases. Semiology ; Pepsinogens - blood ; Prospective Studies ; Sex Factors ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Young Adult</subject><ispartof>European journal of gastroenterology &amp; hepatology, 2009-06, Vol.21 (6), p.606-612</ispartof><rights>2009 Lippincott Williams &amp; Wilkins, Inc.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4517-55a59ce9d359a2060a6a797b54b18f9f9e21cfb2a150692c92a7b893fc8c927a3</citedby><cites>FETCH-LOGICAL-c4517-55a59ce9d359a2060a6a797b54b18f9f9e21cfb2a150692c92a7b893fc8c927a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=21533076$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19293719$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Hyun Young</creatorcontrib><creatorcontrib>Kim, Nayoung</creatorcontrib><creatorcontrib>Kang, Jung Mook</creatorcontrib><creatorcontrib>Park, Young Soo</creatorcontrib><creatorcontrib>Lee, Dong Ho</creatorcontrib><creatorcontrib>Kim, Yu Rim</creatorcontrib><creatorcontrib>Kim, Joo Sung</creatorcontrib><creatorcontrib>Jung, Hyun Chae</creatorcontrib><creatorcontrib>Song, In Sung</creatorcontrib><title>Clinical meaning of pepsinogen test and Helicobacter pylori serology in the health check-up population in Korea</title><title>European journal of gastroenterology &amp; hepatology</title><addtitle>Eur J Gastroenterol Hepatol</addtitle><description><![CDATA[OBJECTIVEThis study was performed to assess the affects of age, sex, and Helicobacter pylori status on pepsinogen testing for atrophic gastritis and to establish the clinical implications of pepsinogen test results and H. pylori serology in a Korean population presenting for a health check-up. METHODSSerum pepsinogen (PG) I and PG II, and H. pylori IgG were measured in 1485 adults. The PG values were analyzed based on age, sex, and H. pylori status, and the cutoff value for atrophic gastritis was determined. RESULTSSerum PG I (sPGI) and sPGII were higher in H. pylori positive than in H. pylori negative individuals (sPGI, 56.3 vs. 42.2 μg/l, P<0.001; sPGII, 17.5 vs. 8.0 μg/l, P<0.001). The PG I/II ratio was lower in H. pylori positive than in H. pylori negative individuals (3.7 vs. 6.0, P<0.001). The sPGII and PG I/II ratio had a positive (r=0.132, P<0.001) and negative correlation with age (r=−0.229, P<0.001), respectively. Men had a higher sPGI (54.7 μg/l) than did women (48.4 μg/l) (P<0.001) but the PG I/II ratio was not statistically different and neither the atrophic gastritis. The PG I/II cutoff value for atrophic gastritis was 6.0 for H. pylori negative and 3.0 for H. pylori positive individuals. sPGI and sPGII were, however, not specific for atrophic gastritis. CONCLUSIONThe H. pylori IgG status, age, and sex were associated with the serum PG levels. To increase the efficacy of the PG I/II ratio for the detection of atrophic gastritis, the cutoff value of the PG I/II ratio should be stratified according to the H. pylori IgG status in the Korean population presenting for a health check-up.]]></description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Distribution</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antibodies, Bacterial - blood</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the digestive system and abdomen</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Clinical Enzyme Tests - methods</subject><subject>Female</subject><subject>Gastritis, Atrophic - diagnosis</subject><subject>Gastritis, Atrophic - microbiology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Helicobacter Infections - complications</subject><subject>Helicobacter Infections - enzymology</subject><subject>Helicobacter pylori - immunology</subject><subject>Helicobacter pylori - isolation &amp; purification</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Immunoglobulin G - blood</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Mass Screening - methods</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Other diseases. Semiology</subject><subject>Pepsinogens - blood</subject><subject>Prospective Studies</subject><subject>Sex Factors</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Young Adult</subject><issn>0954-691X</issn><issn>1473-5687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1v2zAQhomiReO4_QdFwKXIJJcURVEcCyOJg7jokgDdhBN9stnQpEpKCPzvw8BGA2TIdDc87308hHzjbMGZVj9-Xd0sWMe4QFE2gjW1kuoDmfFKiULWjfpIZkzLqqg1_3NGzlP6yxhXgqvP5IzrUgvF9YyEpbPeGnB0j-Ct39LQ0wGHZH3YoqcjppGC39AVOmtCB2bESIeDC9HShDG4sD1Qm8Ed0h2CG3fU7NA8FtNAhzBMDkYb_AtxFyLCF_KpB5fw66nOycP11f1yVax_39wuf64LU0muCilBaoN6I6SGktUMalBadbLqeNPrXmPJTd-VwCWrdWl0CaprtOhNk3sFYk4uj3OHGP5N-Yl2b5NB58BjmFKrhGC6Zg3PZHUkTQwpRezbIdo9xEPLWftius2m27emc-zitGDq9rh5DZ3UZuD7CYCU_fYRvLHpP1dymU9QdeaaI_cUXHabHt30hLE9unz_hmdat5mf</recordid><startdate>200906</startdate><enddate>200906</enddate><creator>Kim, Hyun Young</creator><creator>Kim, Nayoung</creator><creator>Kang, Jung Mook</creator><creator>Park, Young Soo</creator><creator>Lee, Dong Ho</creator><creator>Kim, Yu Rim</creator><creator>Kim, Joo Sung</creator><creator>Jung, Hyun Chae</creator><creator>Song, In Sung</creator><general>Lippincott Williams &amp; Wilkins, Inc</general><general>Lippincott Williams &amp; Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200906</creationdate><title>Clinical meaning of pepsinogen test and Helicobacter pylori serology in the health check-up population in Korea</title><author>Kim, Hyun Young ; Kim, Nayoung ; Kang, Jung Mook ; Park, Young Soo ; Lee, Dong Ho ; Kim, Yu Rim ; Kim, Joo Sung ; Jung, Hyun Chae ; Song, In Sung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4517-55a59ce9d359a2060a6a797b54b18f9f9e21cfb2a150692c92a7b893fc8c927a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Distribution</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antibodies, Bacterial - blood</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the digestive system and abdomen</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Clinical Enzyme Tests - methods</topic><topic>Female</topic><topic>Gastritis, Atrophic - diagnosis</topic><topic>Gastritis, Atrophic - microbiology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Helicobacter Infections - complications</topic><topic>Helicobacter Infections - enzymology</topic><topic>Helicobacter pylori - immunology</topic><topic>Helicobacter pylori - isolation &amp; purification</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Immunoglobulin G - blood</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Mass Screening - methods</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Other diseases. Semiology</topic><topic>Pepsinogens - blood</topic><topic>Prospective Studies</topic><topic>Sex Factors</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Hyun Young</creatorcontrib><creatorcontrib>Kim, Nayoung</creatorcontrib><creatorcontrib>Kang, Jung Mook</creatorcontrib><creatorcontrib>Park, Young Soo</creatorcontrib><creatorcontrib>Lee, Dong Ho</creatorcontrib><creatorcontrib>Kim, Yu Rim</creatorcontrib><creatorcontrib>Kim, Joo Sung</creatorcontrib><creatorcontrib>Jung, Hyun Chae</creatorcontrib><creatorcontrib>Song, In Sung</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of gastroenterology &amp; hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Hyun Young</au><au>Kim, Nayoung</au><au>Kang, Jung Mook</au><au>Park, Young Soo</au><au>Lee, Dong Ho</au><au>Kim, Yu Rim</au><au>Kim, Joo Sung</au><au>Jung, Hyun Chae</au><au>Song, In Sung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical meaning of pepsinogen test and Helicobacter pylori serology in the health check-up population in Korea</atitle><jtitle>European journal of gastroenterology &amp; hepatology</jtitle><addtitle>Eur J Gastroenterol Hepatol</addtitle><date>2009-06</date><risdate>2009</risdate><volume>21</volume><issue>6</issue><spage>606</spage><epage>612</epage><pages>606-612</pages><issn>0954-691X</issn><eissn>1473-5687</eissn><abstract><![CDATA[OBJECTIVEThis study was performed to assess the affects of age, sex, and Helicobacter pylori status on pepsinogen testing for atrophic gastritis and to establish the clinical implications of pepsinogen test results and H. pylori serology in a Korean population presenting for a health check-up. METHODSSerum pepsinogen (PG) I and PG II, and H. pylori IgG were measured in 1485 adults. The PG values were analyzed based on age, sex, and H. pylori status, and the cutoff value for atrophic gastritis was determined. RESULTSSerum PG I (sPGI) and sPGII were higher in H. pylori positive than in H. pylori negative individuals (sPGI, 56.3 vs. 42.2 μg/l, P<0.001; sPGII, 17.5 vs. 8.0 μg/l, P<0.001). The PG I/II ratio was lower in H. pylori positive than in H. pylori negative individuals (3.7 vs. 6.0, P<0.001). The sPGII and PG I/II ratio had a positive (r=0.132, P<0.001) and negative correlation with age (r=−0.229, P<0.001), respectively. Men had a higher sPGI (54.7 μg/l) than did women (48.4 μg/l) (P<0.001) but the PG I/II ratio was not statistically different and neither the atrophic gastritis. The PG I/II cutoff value for atrophic gastritis was 6.0 for H. pylori negative and 3.0 for H. pylori positive individuals. sPGI and sPGII were, however, not specific for atrophic gastritis. CONCLUSIONThe H. pylori IgG status, age, and sex were associated with the serum PG levels. To increase the efficacy of the PG I/II ratio for the detection of atrophic gastritis, the cutoff value of the PG I/II ratio should be stratified according to the H. pylori IgG status in the Korean population presenting for a health check-up.]]></abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams &amp; Wilkins, Inc</pub><pmid>19293719</pmid><doi>10.1097/MEG.0b013e3283086757</doi><tpages>7</tpages></addata></record>
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subjects Adolescent
Adult
Age Distribution
Age Factors
Aged
Aged, 80 and over
Antibodies, Bacterial - blood
Bacterial diseases
Bacterial diseases of the digestive system and abdomen
Biological and medical sciences
Biomarkers - blood
Clinical Enzyme Tests - methods
Female
Gastritis, Atrophic - diagnosis
Gastritis, Atrophic - microbiology
Gastroenterology. Liver. Pancreas. Abdomen
Helicobacter Infections - complications
Helicobacter Infections - enzymology
Helicobacter pylori - immunology
Helicobacter pylori - isolation & purification
Human bacterial diseases
Humans
Immunoglobulin G - blood
Infectious diseases
Male
Mass Screening - methods
Medical sciences
Middle Aged
Other diseases. Semiology
Pepsinogens - blood
Prospective Studies
Sex Factors
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Young Adult
title Clinical meaning of pepsinogen test and Helicobacter pylori serology in the health check-up population in Korea
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