Clinical meaning of pepsinogen test and Helicobacter pylori serology in the health check-up population in Korea
OBJECTIVEThis study was performed to assess the affects of age, sex, and Helicobacter pylori status on pepsinogen testing for atrophic gastritis and to establish the clinical implications of pepsinogen test results and H. pylori serology in a Korean population presenting for a health check-up. METHO...
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| Veröffentlicht in: | European journal of gastroenterology & hepatology 2009-06, Vol.21 (6), p.606-612 |
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| container_title | European journal of gastroenterology & hepatology |
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| creator | Kim, Hyun Young Kim, Nayoung Kang, Jung Mook Park, Young Soo Lee, Dong Ho Kim, Yu Rim Kim, Joo Sung Jung, Hyun Chae Song, In Sung |
| description | OBJECTIVEThis study was performed to assess the affects of age, sex, and Helicobacter pylori status on pepsinogen testing for atrophic gastritis and to establish the clinical implications of pepsinogen test results and H. pylori serology in a Korean population presenting for a health check-up.
METHODSSerum pepsinogen (PG) I and PG II, and H. pylori IgG were measured in 1485 adults. The PG values were analyzed based on age, sex, and H. pylori status, and the cutoff value for atrophic gastritis was determined.
RESULTSSerum PG I (sPGI) and sPGII were higher in H. pylori positive than in H. pylori negative individuals (sPGI, 56.3 vs. 42.2 μg/l, P |
| doi_str_mv | 10.1097/MEG.0b013e3283086757 |
| format | Article |
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METHODSSerum pepsinogen (PG) I and PG II, and H. pylori IgG were measured in 1485 adults. The PG values were analyzed based on age, sex, and H. pylori status, and the cutoff value for atrophic gastritis was determined.
RESULTSSerum PG I (sPGI) and sPGII were higher in H. pylori positive than in H. pylori negative individuals (sPGI, 56.3 vs. 42.2 μg/l, P<0.001; sPGII, 17.5 vs. 8.0 μg/l, P<0.001). The PG I/II ratio was lower in H. pylori positive than in H. pylori negative individuals (3.7 vs. 6.0, P<0.001). The sPGII and PG I/II ratio had a positive (r=0.132, P<0.001) and negative correlation with age (r=−0.229, P<0.001), respectively. Men had a higher sPGI (54.7 μg/l) than did women (48.4 μg/l) (P<0.001) but the PG I/II ratio was not statistically different and neither the atrophic gastritis. The PG I/II cutoff value for atrophic gastritis was 6.0 for H. pylori negative and 3.0 for H. pylori positive individuals. sPGI and sPGII were, however, not specific for atrophic gastritis.
CONCLUSIONThe H. pylori IgG status, age, and sex were associated with the serum PG levels. To increase the efficacy of the PG I/II ratio for the detection of atrophic gastritis, the cutoff value of the PG I/II ratio should be stratified according to the H. pylori IgG status in the Korean population presenting for a health check-up.]]></description><identifier>ISSN: 0954-691X</identifier><identifier>EISSN: 1473-5687</identifier><identifier>DOI: 10.1097/MEG.0b013e3283086757</identifier><identifier>PMID: 19293719</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Adolescent ; Adult ; Age Distribution ; Age Factors ; Aged ; Aged, 80 and over ; Antibodies, Bacterial - blood ; Bacterial diseases ; Bacterial diseases of the digestive system and abdomen ; Biological and medical sciences ; Biomarkers - blood ; Clinical Enzyme Tests - methods ; Female ; Gastritis, Atrophic - diagnosis ; Gastritis, Atrophic - microbiology ; Gastroenterology. Liver. Pancreas. Abdomen ; Helicobacter Infections - complications ; Helicobacter Infections - enzymology ; Helicobacter pylori - immunology ; Helicobacter pylori - isolation & purification ; Human bacterial diseases ; Humans ; Immunoglobulin G - blood ; Infectious diseases ; Male ; Mass Screening - methods ; Medical sciences ; Middle Aged ; Other diseases. Semiology ; Pepsinogens - blood ; Prospective Studies ; Sex Factors ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Young Adult</subject><ispartof>European journal of gastroenterology & hepatology, 2009-06, Vol.21 (6), p.606-612</ispartof><rights>2009 Lippincott Williams & Wilkins, Inc.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4517-55a59ce9d359a2060a6a797b54b18f9f9e21cfb2a150692c92a7b893fc8c927a3</citedby><cites>FETCH-LOGICAL-c4517-55a59ce9d359a2060a6a797b54b18f9f9e21cfb2a150692c92a7b893fc8c927a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21533076$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19293719$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Hyun Young</creatorcontrib><creatorcontrib>Kim, Nayoung</creatorcontrib><creatorcontrib>Kang, Jung Mook</creatorcontrib><creatorcontrib>Park, Young Soo</creatorcontrib><creatorcontrib>Lee, Dong Ho</creatorcontrib><creatorcontrib>Kim, Yu Rim</creatorcontrib><creatorcontrib>Kim, Joo Sung</creatorcontrib><creatorcontrib>Jung, Hyun Chae</creatorcontrib><creatorcontrib>Song, In Sung</creatorcontrib><title>Clinical meaning of pepsinogen test and Helicobacter pylori serology in the health check-up population in Korea</title><title>European journal of gastroenterology & hepatology</title><addtitle>Eur J Gastroenterol Hepatol</addtitle><description><![CDATA[OBJECTIVEThis study was performed to assess the affects of age, sex, and Helicobacter pylori status on pepsinogen testing for atrophic gastritis and to establish the clinical implications of pepsinogen test results and H. pylori serology in a Korean population presenting for a health check-up.
METHODSSerum pepsinogen (PG) I and PG II, and H. pylori IgG were measured in 1485 adults. The PG values were analyzed based on age, sex, and H. pylori status, and the cutoff value for atrophic gastritis was determined.
RESULTSSerum PG I (sPGI) and sPGII were higher in H. pylori positive than in H. pylori negative individuals (sPGI, 56.3 vs. 42.2 μg/l, P<0.001; sPGII, 17.5 vs. 8.0 μg/l, P<0.001). The PG I/II ratio was lower in H. pylori positive than in H. pylori negative individuals (3.7 vs. 6.0, P<0.001). The sPGII and PG I/II ratio had a positive (r=0.132, P<0.001) and negative correlation with age (r=−0.229, P<0.001), respectively. Men had a higher sPGI (54.7 μg/l) than did women (48.4 μg/l) (P<0.001) but the PG I/II ratio was not statistically different and neither the atrophic gastritis. The PG I/II cutoff value for atrophic gastritis was 6.0 for H. pylori negative and 3.0 for H. pylori positive individuals. sPGI and sPGII were, however, not specific for atrophic gastritis.
CONCLUSIONThe H. pylori IgG status, age, and sex were associated with the serum PG levels. To increase the efficacy of the PG I/II ratio for the detection of atrophic gastritis, the cutoff value of the PG I/II ratio should be stratified according to the H. pylori IgG status in the Korean population presenting for a health check-up.]]></description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Distribution</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antibodies, Bacterial - blood</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the digestive system and abdomen</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Clinical Enzyme Tests - methods</subject><subject>Female</subject><subject>Gastritis, Atrophic - diagnosis</subject><subject>Gastritis, Atrophic - microbiology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Helicobacter Infections - complications</subject><subject>Helicobacter Infections - enzymology</subject><subject>Helicobacter pylori - immunology</subject><subject>Helicobacter pylori - isolation & purification</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Immunoglobulin G - blood</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Mass Screening - methods</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Other diseases. Semiology</subject><subject>Pepsinogens - blood</subject><subject>Prospective Studies</subject><subject>Sex Factors</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Young Adult</subject><issn>0954-691X</issn><issn>1473-5687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1v2zAQhomiReO4_QdFwKXIJJcURVEcCyOJg7jokgDdhBN9stnQpEpKCPzvw8BGA2TIdDc87308hHzjbMGZVj9-Xd0sWMe4QFE2gjW1kuoDmfFKiULWjfpIZkzLqqg1_3NGzlP6yxhXgqvP5IzrUgvF9YyEpbPeGnB0j-Ct39LQ0wGHZH3YoqcjppGC39AVOmtCB2bESIeDC9HShDG4sD1Qm8Ed0h2CG3fU7NA8FtNAhzBMDkYb_AtxFyLCF_KpB5fw66nOycP11f1yVax_39wuf64LU0muCilBaoN6I6SGktUMalBadbLqeNPrXmPJTd-VwCWrdWl0CaprtOhNk3sFYk4uj3OHGP5N-Yl2b5NB58BjmFKrhGC6Zg3PZHUkTQwpRezbIdo9xEPLWftius2m27emc-zitGDq9rh5DZ3UZuD7CYCU_fYRvLHpP1dymU9QdeaaI_cUXHabHt30hLE9unz_hmdat5mf</recordid><startdate>200906</startdate><enddate>200906</enddate><creator>Kim, Hyun Young</creator><creator>Kim, Nayoung</creator><creator>Kang, Jung Mook</creator><creator>Park, Young Soo</creator><creator>Lee, Dong Ho</creator><creator>Kim, Yu Rim</creator><creator>Kim, Joo Sung</creator><creator>Jung, Hyun Chae</creator><creator>Song, In Sung</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200906</creationdate><title>Clinical meaning of pepsinogen test and Helicobacter pylori serology in the health check-up population in Korea</title><author>Kim, Hyun Young ; Kim, Nayoung ; Kang, Jung Mook ; Park, Young Soo ; Lee, Dong Ho ; Kim, Yu Rim ; Kim, Joo Sung ; Jung, Hyun Chae ; Song, In Sung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4517-55a59ce9d359a2060a6a797b54b18f9f9e21cfb2a150692c92a7b893fc8c927a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Distribution</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antibodies, Bacterial - blood</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the digestive system and abdomen</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Clinical Enzyme Tests - methods</topic><topic>Female</topic><topic>Gastritis, Atrophic - diagnosis</topic><topic>Gastritis, Atrophic - microbiology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Helicobacter Infections - complications</topic><topic>Helicobacter Infections - enzymology</topic><topic>Helicobacter pylori - immunology</topic><topic>Helicobacter pylori - isolation & purification</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Immunoglobulin G - blood</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Mass Screening - methods</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Other diseases. Semiology</topic><topic>Pepsinogens - blood</topic><topic>Prospective Studies</topic><topic>Sex Factors</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Hyun Young</creatorcontrib><creatorcontrib>Kim, Nayoung</creatorcontrib><creatorcontrib>Kang, Jung Mook</creatorcontrib><creatorcontrib>Park, Young Soo</creatorcontrib><creatorcontrib>Lee, Dong Ho</creatorcontrib><creatorcontrib>Kim, Yu Rim</creatorcontrib><creatorcontrib>Kim, Joo Sung</creatorcontrib><creatorcontrib>Jung, Hyun Chae</creatorcontrib><creatorcontrib>Song, In Sung</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of gastroenterology & hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Hyun Young</au><au>Kim, Nayoung</au><au>Kang, Jung Mook</au><au>Park, Young Soo</au><au>Lee, Dong Ho</au><au>Kim, Yu Rim</au><au>Kim, Joo Sung</au><au>Jung, Hyun Chae</au><au>Song, In Sung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical meaning of pepsinogen test and Helicobacter pylori serology in the health check-up population in Korea</atitle><jtitle>European journal of gastroenterology & hepatology</jtitle><addtitle>Eur J Gastroenterol Hepatol</addtitle><date>2009-06</date><risdate>2009</risdate><volume>21</volume><issue>6</issue><spage>606</spage><epage>612</epage><pages>606-612</pages><issn>0954-691X</issn><eissn>1473-5687</eissn><abstract><![CDATA[OBJECTIVEThis study was performed to assess the affects of age, sex, and Helicobacter pylori status on pepsinogen testing for atrophic gastritis and to establish the clinical implications of pepsinogen test results and H. pylori serology in a Korean population presenting for a health check-up.
METHODSSerum pepsinogen (PG) I and PG II, and H. pylori IgG were measured in 1485 adults. The PG values were analyzed based on age, sex, and H. pylori status, and the cutoff value for atrophic gastritis was determined.
RESULTSSerum PG I (sPGI) and sPGII were higher in H. pylori positive than in H. pylori negative individuals (sPGI, 56.3 vs. 42.2 μg/l, P<0.001; sPGII, 17.5 vs. 8.0 μg/l, P<0.001). The PG I/II ratio was lower in H. pylori positive than in H. pylori negative individuals (3.7 vs. 6.0, P<0.001). The sPGII and PG I/II ratio had a positive (r=0.132, P<0.001) and negative correlation with age (r=−0.229, P<0.001), respectively. Men had a higher sPGI (54.7 μg/l) than did women (48.4 μg/l) (P<0.001) but the PG I/II ratio was not statistically different and neither the atrophic gastritis. The PG I/II cutoff value for atrophic gastritis was 6.0 for H. pylori negative and 3.0 for H. pylori positive individuals. sPGI and sPGII were, however, not specific for atrophic gastritis.
CONCLUSIONThe H. pylori IgG status, age, and sex were associated with the serum PG levels. To increase the efficacy of the PG I/II ratio for the detection of atrophic gastritis, the cutoff value of the PG I/II ratio should be stratified according to the H. pylori IgG status in the Korean population presenting for a health check-up.]]></abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>19293719</pmid><doi>10.1097/MEG.0b013e3283086757</doi><tpages>7</tpages></addata></record> |
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| ispartof | European journal of gastroenterology & hepatology, 2009-06, Vol.21 (6), p.606-612 |
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| subjects | Adolescent Adult Age Distribution Age Factors Aged Aged, 80 and over Antibodies, Bacterial - blood Bacterial diseases Bacterial diseases of the digestive system and abdomen Biological and medical sciences Biomarkers - blood Clinical Enzyme Tests - methods Female Gastritis, Atrophic - diagnosis Gastritis, Atrophic - microbiology Gastroenterology. Liver. Pancreas. Abdomen Helicobacter Infections - complications Helicobacter Infections - enzymology Helicobacter pylori - immunology Helicobacter pylori - isolation & purification Human bacterial diseases Humans Immunoglobulin G - blood Infectious diseases Male Mass Screening - methods Medical sciences Middle Aged Other diseases. Semiology Pepsinogens - blood Prospective Studies Sex Factors Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Young Adult |
| title | Clinical meaning of pepsinogen test and Helicobacter pylori serology in the health check-up population in Korea |
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