Heat Induced Conformational Changes Generate Mitogenicity to Splenocytes by Sclerogen from Sclerotinia sclerotiorum IFO 9395

The fungal mitogen, sclerogen, obtained from sclerotia of Sclerotinia scleotiorum IFO 9395 showed significant mitogenic activity to murine splenocytes after heat denaturation in relation to polymerization. To evaluate the conditions generating mitogenicity, we performed several chromatographic and s...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1992/09/25, Vol.40(9), pp.2562-2564
Hauptverfasser: SHINOHARA, Hisami, OHNO, Naohito, YADOMAE, Toshiro
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Sprache:eng
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