Endothelin-1 enhances responses to sympathetic nerve stimulation in endothelium-denuded and endothelium-intact rabbit ear arteries

Endothelin-1 enhances responses to sympathetic nerve stimulation in endothelium-denuded and endothelium-intact rabbit ear arteries

In the rabbit isolated and endothelium-denuded ear artery, endothelin-1 (1–10 nM) elicited concentration-dependent vasoconstrictor responses. Lower concentrations of endothelin-1 (0.1, 0.3 and 1 nM) with little or no direct vasoconstrictor action significantly enhanced responses to sympathetic nerve...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Neurochemistry international 1991, Vol.18 (4), p.465-469
Hauptverfasser: La, M., Wong-Dusting, H.K., Rand, M.J.
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 469
container_issue 4
container_start_page 465
container_title Neurochemistry international
container_volume 18
creator La, M.
Wong-Dusting, H.K.
Rand, M.J.
description In the rabbit isolated and endothelium-denuded ear artery, endothelin-1 (1–10 nM) elicited concentration-dependent vasoconstrictor responses. Lower concentrations of endothelin-1 (0.1, 0.3 and 1 nM) with little or no direct vasoconstrictor action significantly enhanced responses to sympathetic nerve stimulation in both endothelium-denuded and endothelium-intact arteries. The vasoconstrictor action of endothelin-1 and its enhancing effect on stimulation-induced responses were significantly decreased by the presence of the dihydropyridine-type calcium channel antagonist nicardipine (10 nM). The enhancing effect of low concentrations of endothelin-1 on responses to sympathetic nerve stimulation may play a role in the regulation of vascular tone.
doi_str_mv 10.1016/0197-0186(91)90140-9
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733093964</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0197018691901409</els_id><sourcerecordid>733093964</sourcerecordid><originalsourceid>FETCH-LOGICAL-c390t-11ac87935a2cda9e2b5bd5195f342fb61b1dade45ed36fec48c875da443d30593</originalsourceid><addsrcrecordid>eNp9kUFLHDEUx4NUdF39BqXk1OphbN4kmdlchCJqhQUv9hwyyRtMmclsk4zgtZ_crLsVevGUR_j9_w_ej5DPwC6BQfOdgWorBqvmXMGFYiBYpQ7IAlZtXalWik9k8Y4ck5OUfjPGWsXkETmumWSirZsF-XsT3JSfcPChAorhyQSLiUZMmymkMuWJppdxYwqTvaUB4zPSlP04Dyb7KVAfSmzfMY-VwzA7dNQE99-_D9nYTKPpOp8pmkhNzBg9plNy2Jsh4dn-XZJftzeP1z-r9cPd_fWPdWW5YrkCMHbVKi5NbZ1RWHeycxKU7Lmo-66BDpxxKCQ63vRoxarg0hkhuONMKr4k33a9mzj9mTFlPfpkcRhMwGlOuuWcKa4aUcivH5IgS3M5bgHFDrRxSilirzfRjya-aGB6a0lvFeitAq1Av1nS29iXff_cjejeQ_-0FOBqB2C5x7PHqJP1WMw4H9Fm7Sb_8YZX8UOkaA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15875019</pqid></control><display><type>article</type><title>Endothelin-1 enhances responses to sympathetic nerve stimulation in endothelium-denuded and endothelium-intact rabbit ear arteries</title><source>Access via ScienceDirect (Elsevier)</source><creator>La, M. ; Wong-Dusting, H.K. ; Rand, M.J.</creator><creatorcontrib>La, M. ; Wong-Dusting, H.K. ; Rand, M.J.</creatorcontrib><description>In the rabbit isolated and endothelium-denuded ear artery, endothelin-1 (1–10 nM) elicited concentration-dependent vasoconstrictor responses. Lower concentrations of endothelin-1 (0.1, 0.3 and 1 nM) with little or no direct vasoconstrictor action significantly enhanced responses to sympathetic nerve stimulation in both endothelium-denuded and endothelium-intact arteries. The vasoconstrictor action of endothelin-1 and its enhancing effect on stimulation-induced responses were significantly decreased by the presence of the dihydropyridine-type calcium channel antagonist nicardipine (10 nM). The enhancing effect of low concentrations of endothelin-1 on responses to sympathetic nerve stimulation may play a role in the regulation of vascular tone.</description><identifier>ISSN: 0197-0186</identifier><identifier>EISSN: 1872-9754</identifier><identifier>DOI: 10.1016/0197-0186(91)90140-9</identifier><identifier>PMID: 20504726</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><ispartof>Neurochemistry international, 1991, Vol.18 (4), p.465-469</ispartof><rights>1991</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-11ac87935a2cda9e2b5bd5195f342fb61b1dade45ed36fec48c875da443d30593</citedby><cites>FETCH-LOGICAL-c390t-11ac87935a2cda9e2b5bd5195f342fb61b1dade45ed36fec48c875da443d30593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0197-0186(91)90140-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20504726$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>La, M.</creatorcontrib><creatorcontrib>Wong-Dusting, H.K.</creatorcontrib><creatorcontrib>Rand, M.J.</creatorcontrib><title>Endothelin-1 enhances responses to sympathetic nerve stimulation in endothelium-denuded and endothelium-intact rabbit ear arteries</title><title>Neurochemistry international</title><addtitle>Neurochem Int</addtitle><description>In the rabbit isolated and endothelium-denuded ear artery, endothelin-1 (1–10 nM) elicited concentration-dependent vasoconstrictor responses. Lower concentrations of endothelin-1 (0.1, 0.3 and 1 nM) with little or no direct vasoconstrictor action significantly enhanced responses to sympathetic nerve stimulation in both endothelium-denuded and endothelium-intact arteries. The vasoconstrictor action of endothelin-1 and its enhancing effect on stimulation-induced responses were significantly decreased by the presence of the dihydropyridine-type calcium channel antagonist nicardipine (10 nM). The enhancing effect of low concentrations of endothelin-1 on responses to sympathetic nerve stimulation may play a role in the regulation of vascular tone.</description><issn>0197-0186</issn><issn>1872-9754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><recordid>eNp9kUFLHDEUx4NUdF39BqXk1OphbN4kmdlchCJqhQUv9hwyyRtMmclsk4zgtZ_crLsVevGUR_j9_w_ej5DPwC6BQfOdgWorBqvmXMGFYiBYpQ7IAlZtXalWik9k8Y4ck5OUfjPGWsXkETmumWSirZsF-XsT3JSfcPChAorhyQSLiUZMmymkMuWJppdxYwqTvaUB4zPSlP04Dyb7KVAfSmzfMY-VwzA7dNQE99-_D9nYTKPpOp8pmkhNzBg9plNy2Jsh4dn-XZJftzeP1z-r9cPd_fWPdWW5YrkCMHbVKi5NbZ1RWHeycxKU7Lmo-66BDpxxKCQ63vRoxarg0hkhuONMKr4k33a9mzj9mTFlPfpkcRhMwGlOuuWcKa4aUcivH5IgS3M5bgHFDrRxSilirzfRjya-aGB6a0lvFeitAq1Av1nS29iXff_cjejeQ_-0FOBqB2C5x7PHqJP1WMw4H9Fm7Sb_8YZX8UOkaA</recordid><startdate>1991</startdate><enddate>1991</enddate><creator>La, M.</creator><creator>Wong-Dusting, H.K.</creator><creator>Rand, M.J.</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>1991</creationdate><title>Endothelin-1 enhances responses to sympathetic nerve stimulation in endothelium-denuded and endothelium-intact rabbit ear arteries</title><author>La, M. ; Wong-Dusting, H.K. ; Rand, M.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-11ac87935a2cda9e2b5bd5195f342fb61b1dade45ed36fec48c875da443d30593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>La, M.</creatorcontrib><creatorcontrib>Wong-Dusting, H.K.</creatorcontrib><creatorcontrib>Rand, M.J.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neurochemistry international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>La, M.</au><au>Wong-Dusting, H.K.</au><au>Rand, M.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endothelin-1 enhances responses to sympathetic nerve stimulation in endothelium-denuded and endothelium-intact rabbit ear arteries</atitle><jtitle>Neurochemistry international</jtitle><addtitle>Neurochem Int</addtitle><date>1991</date><risdate>1991</risdate><volume>18</volume><issue>4</issue><spage>465</spage><epage>469</epage><pages>465-469</pages><issn>0197-0186</issn><eissn>1872-9754</eissn><abstract>In the rabbit isolated and endothelium-denuded ear artery, endothelin-1 (1–10 nM) elicited concentration-dependent vasoconstrictor responses. Lower concentrations of endothelin-1 (0.1, 0.3 and 1 nM) with little or no direct vasoconstrictor action significantly enhanced responses to sympathetic nerve stimulation in both endothelium-denuded and endothelium-intact arteries. The vasoconstrictor action of endothelin-1 and its enhancing effect on stimulation-induced responses were significantly decreased by the presence of the dihydropyridine-type calcium channel antagonist nicardipine (10 nM). The enhancing effect of low concentrations of endothelin-1 on responses to sympathetic nerve stimulation may play a role in the regulation of vascular tone.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>20504726</pmid><doi>10.1016/0197-0186(91)90140-9</doi><tpages>5</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0197-0186
ispartof Neurochemistry international, 1991, Vol.18 (4), p.465-469
issn 0197-0186
1872-9754
language eng
recordid cdi_proquest_miscellaneous_733093964
source Access via ScienceDirect (Elsevier)
title Endothelin-1 enhances responses to sympathetic nerve stimulation in endothelium-denuded and endothelium-intact rabbit ear arteries
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-18T19%3A45%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Endothelin-1%20enhances%20responses%20to%20sympathetic%20nerve%20stimulation%20in%20endothelium-denuded%20and%20endothelium-intact%20rabbit%20ear%20arteries&rft.jtitle=Neurochemistry%20international&rft.au=La,%20M.&rft.date=1991&rft.volume=18&rft.issue=4&rft.spage=465&rft.epage=469&rft.pages=465-469&rft.issn=0197-0186&rft.eissn=1872-9754&rft_id=info:doi/10.1016/0197-0186(91)90140-9&rft_dat=%3Cproquest_cross%3E733093964%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=15875019&rft_id=info:pmid/20504726&rft_els_id=0197018691901409&rfr_iscdi=true