Relation Between Plaque Components and Plaque Prolapse After Drug-Eluting Stent Implantation: Virtual Histology - Intravascular Ultrasound
Background: It is not well known which plaque components are associated with the development of plaque prolapse (PP) and what are the major components in prolapsed plaque. The relationship between pre-stenting plaque components and post-stenting PP was assessed and the plaque components of prolapsed...
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| Veröffentlicht in: | Circulation Journal 2010, Vol.74(6), pp.1142-1151 |
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| creator | Hong, Young Joon Jeong, Myung Ho Kim, Sang Wook Choi, Yun Ha Ma, Eun Hae Ko, Jum Suk Lee, Min Goo Park, Keun Ho Sim, Doo Sun Yoon, Nam Sik Yoon, Hyun Ju Kim, Kye Hun Park, Hyung Wook Kim, Ju Han Ahn, Youngkeun Cho, Jeong Gwan Park, Jong Chun Kang, Jung Chaee |
| description | Background: It is not well known which plaque components are associated with the development of plaque prolapse (PP) and what are the major components in prolapsed plaque. The relationship between pre-stenting plaque components and post-stenting PP was assessed and the plaque components of prolapsed plaque were evaluated in patients who underwent drug-eluting stent (DES) implantation using virtual histology - intravascular ultrasound (VH-IVUS). Methods and Results: The study group consisted of 132 patients who underwent DES implantation and pre- and post-stenting VH-IVUS. Of these patients, 68 patients had 76 PP lesions and 64 patients had 76 non-PP lesions. Intra-stent PP volume was 3.6±1.5 mm3. Plaque volume was significantly greater and absolute fibrotic (FT) and necrotic core (NC) volumes were significantly greater in PP lesions compared with non-PP lesions. On multivariate analysis, absolute NC (odds ratios [OR]=1.14, P |
| doi_str_mv | 10.1253/circj.CJ-09-0781 |
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The relationship between pre-stenting plaque components and post-stenting PP was assessed and the plaque components of prolapsed plaque were evaluated in patients who underwent drug-eluting stent (DES) implantation using virtual histology - intravascular ultrasound (VH-IVUS). Methods and Results: The study group consisted of 132 patients who underwent DES implantation and pre- and post-stenting VH-IVUS. Of these patients, 68 patients had 76 PP lesions and 64 patients had 76 non-PP lesions. Intra-stent PP volume was 3.6±1.5 mm3. Plaque volume was significantly greater and absolute fibrotic (FT) and necrotic core (NC) volumes were significantly greater in PP lesions compared with non-PP lesions. On multivariate analysis, absolute NC (odds ratios [OR]=1.14, P<0.001) and FT volume (OR =1.09, P<0.001) were independently associated with the development of PP. In intra-stent prolapsed plaque the FT component was greatest, but the NC component was also large, and %NC volume correlated positively with Δcreatine kinase-MB (r=0.489, P<0.001) and Δtroponin-I (r=0.679, P<0.001), and %FT volume correlated negatively with ΔCK-MB (r=-0.539, P<0.001) and Δtroponin-I. Conclusions: NC and FT components were associated with development of PP; and NC and FT components in prolapsed plaque were associated with cardiac enzyme elevation after DES implantation. (Circ J 2010; 74: 1142 - 1151)</description><identifier>ISSN: 1346-9843</identifier><identifier>EISSN: 1347-4820</identifier><identifier>DOI: 10.1253/circj.CJ-09-0781</identifier><identifier>PMID: 20453386</identifier><language>eng</language><publisher>Japan: The Japanese Circulation Society</publisher><subject>Aged ; Atherosclerosis ; Coronary disease ; Coronary Restenosis - diagnostic imaging ; Coronary Restenosis - pathology ; Drug-Eluting Stents - adverse effects ; Female ; Fibrosis ; Follow-Up Studies ; Humans ; Intravascular ultrasound ; Male ; Middle Aged ; Necrosis ; Prolapse ; Retrospective Studies ; Stent ; Thrombosis - pathology ; Thrombosis - therapy ; Ultrasonography, Interventional</subject><ispartof>Circulation Journal, 2010, Vol.74(6), pp.1142-1151</ispartof><rights>2010 THE JAPANESE CIRCULATION SOCIETY</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c493t-7075786034427a77293d0d336ad3ab9b5f24c334110ebcc929584ab62f4342383</citedby><cites>FETCH-LOGICAL-c493t-7075786034427a77293d0d336ad3ab9b5f24c334110ebcc929584ab62f4342383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20453386$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hong, Young Joon</creatorcontrib><creatorcontrib>Jeong, Myung Ho</creatorcontrib><creatorcontrib>Kim, Sang Wook</creatorcontrib><creatorcontrib>Choi, Yun Ha</creatorcontrib><creatorcontrib>Ma, Eun Hae</creatorcontrib><creatorcontrib>Ko, Jum Suk</creatorcontrib><creatorcontrib>Lee, Min Goo</creatorcontrib><creatorcontrib>Park, Keun Ho</creatorcontrib><creatorcontrib>Sim, Doo Sun</creatorcontrib><creatorcontrib>Yoon, Nam Sik</creatorcontrib><creatorcontrib>Yoon, Hyun Ju</creatorcontrib><creatorcontrib>Kim, Kye Hun</creatorcontrib><creatorcontrib>Park, Hyung Wook</creatorcontrib><creatorcontrib>Kim, Ju Han</creatorcontrib><creatorcontrib>Ahn, Youngkeun</creatorcontrib><creatorcontrib>Cho, Jeong Gwan</creatorcontrib><creatorcontrib>Park, Jong Chun</creatorcontrib><creatorcontrib>Kang, Jung Chaee</creatorcontrib><title>Relation Between Plaque Components and Plaque Prolapse After Drug-Eluting Stent Implantation: Virtual Histology - Intravascular Ultrasound</title><title>Circulation Journal</title><addtitle>Circ J</addtitle><description>Background: It is not well known which plaque components are associated with the development of plaque prolapse (PP) and what are the major components in prolapsed plaque. The relationship between pre-stenting plaque components and post-stenting PP was assessed and the plaque components of prolapsed plaque were evaluated in patients who underwent drug-eluting stent (DES) implantation using virtual histology - intravascular ultrasound (VH-IVUS). Methods and Results: The study group consisted of 132 patients who underwent DES implantation and pre- and post-stenting VH-IVUS. Of these patients, 68 patients had 76 PP lesions and 64 patients had 76 non-PP lesions. Intra-stent PP volume was 3.6±1.5 mm3. Plaque volume was significantly greater and absolute fibrotic (FT) and necrotic core (NC) volumes were significantly greater in PP lesions compared with non-PP lesions. On multivariate analysis, absolute NC (odds ratios [OR]=1.14, P<0.001) and FT volume (OR =1.09, P<0.001) were independently associated with the development of PP. In intra-stent prolapsed plaque the FT component was greatest, but the NC component was also large, and %NC volume correlated positively with Δcreatine kinase-MB (r=0.489, P<0.001) and Δtroponin-I (r=0.679, P<0.001), and %FT volume correlated negatively with ΔCK-MB (r=-0.539, P<0.001) and Δtroponin-I. Conclusions: NC and FT components were associated with development of PP; and NC and FT components in prolapsed plaque were associated with cardiac enzyme elevation after DES implantation. (Circ J 2010; 74: 1142 - 1151)</description><subject>Aged</subject><subject>Atherosclerosis</subject><subject>Coronary disease</subject><subject>Coronary Restenosis - diagnostic imaging</subject><subject>Coronary Restenosis - pathology</subject><subject>Drug-Eluting Stents - adverse effects</subject><subject>Female</subject><subject>Fibrosis</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Intravascular ultrasound</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Necrosis</subject><subject>Prolapse</subject><subject>Retrospective Studies</subject><subject>Stent</subject><subject>Thrombosis - pathology</subject><subject>Thrombosis - therapy</subject><subject>Ultrasonography, Interventional</subject><issn>1346-9843</issn><issn>1347-4820</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMtr3DAQh0Vp6Sab3nsqvvXkdKyRLeuYukm6IdAlj1tAyPJ468WvSjIl_328jySXmWH45mP4MfY1gfOEp_jDNs5uz4ubGFQMMk8-sJMEhYxFzuHjfs5ilQtcsFPvtwBcQao-swUHkSLm2Ql7uqPWhGboo58U_hP10bo1_yaKiqEbh5764CPTV6_btRtaM3qKLupALvrlpk182U6h6TfRfZjpaNWNrenD3nnGPtWm9fTl2Jfs8eryofgd3_65XhUXt7EVCkMsQaYyzwCF4NJIyRVWUCFmpkJTqjKtubCIIkmASmsVV2kuTJnxWqDgmOOSfT94RzfMX_qgu8ZbaudHaJi8loigOGTpTMKBtG7w3lGtR9d0xj3rBPQuUr2PVBc3GpTeRTqffDvKp7Kj6u3gNcMZuDoAWx_Mht4A40JjWzoapdDZrryb34G_xmnq8QUVYour</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>Hong, Young Joon</creator><creator>Jeong, Myung Ho</creator><creator>Kim, Sang Wook</creator><creator>Choi, Yun Ha</creator><creator>Ma, Eun Hae</creator><creator>Ko, Jum Suk</creator><creator>Lee, Min Goo</creator><creator>Park, Keun Ho</creator><creator>Sim, Doo Sun</creator><creator>Yoon, Nam Sik</creator><creator>Yoon, Hyun Ju</creator><creator>Kim, Kye Hun</creator><creator>Park, Hyung Wook</creator><creator>Kim, Ju Han</creator><creator>Ahn, Youngkeun</creator><creator>Cho, Jeong Gwan</creator><creator>Park, Jong Chun</creator><creator>Kang, Jung Chaee</creator><general>The Japanese Circulation Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2010</creationdate><title>Relation Between Plaque Components and Plaque Prolapse After Drug-Eluting Stent Implantation</title><author>Hong, Young Joon ; Jeong, Myung Ho ; Kim, Sang Wook ; Choi, Yun Ha ; Ma, Eun Hae ; Ko, Jum Suk ; Lee, Min Goo ; Park, Keun Ho ; Sim, Doo Sun ; Yoon, Nam Sik ; Yoon, Hyun Ju ; Kim, Kye Hun ; Park, Hyung Wook ; Kim, Ju Han ; Ahn, Youngkeun ; Cho, Jeong Gwan ; Park, Jong Chun ; Kang, Jung Chaee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c493t-7075786034427a77293d0d336ad3ab9b5f24c334110ebcc929584ab62f4342383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Atherosclerosis</topic><topic>Coronary disease</topic><topic>Coronary Restenosis - diagnostic imaging</topic><topic>Coronary Restenosis - pathology</topic><topic>Drug-Eluting Stents - adverse effects</topic><topic>Female</topic><topic>Fibrosis</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Intravascular ultrasound</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Necrosis</topic><topic>Prolapse</topic><topic>Retrospective Studies</topic><topic>Stent</topic><topic>Thrombosis - pathology</topic><topic>Thrombosis - therapy</topic><topic>Ultrasonography, Interventional</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hong, Young Joon</creatorcontrib><creatorcontrib>Jeong, Myung Ho</creatorcontrib><creatorcontrib>Kim, Sang Wook</creatorcontrib><creatorcontrib>Choi, Yun Ha</creatorcontrib><creatorcontrib>Ma, Eun Hae</creatorcontrib><creatorcontrib>Ko, Jum Suk</creatorcontrib><creatorcontrib>Lee, Min Goo</creatorcontrib><creatorcontrib>Park, Keun Ho</creatorcontrib><creatorcontrib>Sim, Doo Sun</creatorcontrib><creatorcontrib>Yoon, Nam Sik</creatorcontrib><creatorcontrib>Yoon, Hyun Ju</creatorcontrib><creatorcontrib>Kim, Kye Hun</creatorcontrib><creatorcontrib>Park, Hyung Wook</creatorcontrib><creatorcontrib>Kim, Ju Han</creatorcontrib><creatorcontrib>Ahn, Youngkeun</creatorcontrib><creatorcontrib>Cho, Jeong Gwan</creatorcontrib><creatorcontrib>Park, Jong Chun</creatorcontrib><creatorcontrib>Kang, Jung Chaee</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hong, Young Joon</au><au>Jeong, Myung Ho</au><au>Kim, Sang Wook</au><au>Choi, Yun Ha</au><au>Ma, Eun Hae</au><au>Ko, Jum Suk</au><au>Lee, Min Goo</au><au>Park, Keun Ho</au><au>Sim, Doo Sun</au><au>Yoon, Nam Sik</au><au>Yoon, Hyun Ju</au><au>Kim, Kye Hun</au><au>Park, Hyung Wook</au><au>Kim, Ju Han</au><au>Ahn, Youngkeun</au><au>Cho, Jeong Gwan</au><au>Park, Jong Chun</au><au>Kang, Jung Chaee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relation Between Plaque Components and Plaque Prolapse After Drug-Eluting Stent Implantation: Virtual Histology - Intravascular Ultrasound</atitle><jtitle>Circulation Journal</jtitle><addtitle>Circ J</addtitle><date>2010</date><risdate>2010</risdate><volume>74</volume><issue>6</issue><spage>1142</spage><epage>1151</epage><pages>1142-1151</pages><issn>1346-9843</issn><eissn>1347-4820</eissn><abstract>Background: It is not well known which plaque components are associated with the development of plaque prolapse (PP) and what are the major components in prolapsed plaque. The relationship between pre-stenting plaque components and post-stenting PP was assessed and the plaque components of prolapsed plaque were evaluated in patients who underwent drug-eluting stent (DES) implantation using virtual histology - intravascular ultrasound (VH-IVUS). Methods and Results: The study group consisted of 132 patients who underwent DES implantation and pre- and post-stenting VH-IVUS. Of these patients, 68 patients had 76 PP lesions and 64 patients had 76 non-PP lesions. Intra-stent PP volume was 3.6±1.5 mm3. Plaque volume was significantly greater and absolute fibrotic (FT) and necrotic core (NC) volumes were significantly greater in PP lesions compared with non-PP lesions. On multivariate analysis, absolute NC (odds ratios [OR]=1.14, P<0.001) and FT volume (OR =1.09, P<0.001) were independently associated with the development of PP. In intra-stent prolapsed plaque the FT component was greatest, but the NC component was also large, and %NC volume correlated positively with Δcreatine kinase-MB (r=0.489, P<0.001) and Δtroponin-I (r=0.679, P<0.001), and %FT volume correlated negatively with ΔCK-MB (r=-0.539, P<0.001) and Δtroponin-I. Conclusions: NC and FT components were associated with development of PP; and NC and FT components in prolapsed plaque were associated with cardiac enzyme elevation after DES implantation. (Circ J 2010; 74: 1142 - 1151)</abstract><cop>Japan</cop><pub>The Japanese Circulation Society</pub><pmid>20453386</pmid><doi>10.1253/circj.CJ-09-0781</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Atherosclerosis Coronary disease Coronary Restenosis - diagnostic imaging Coronary Restenosis - pathology Drug-Eluting Stents - adverse effects Female Fibrosis Follow-Up Studies Humans Intravascular ultrasound Male Middle Aged Necrosis Prolapse Retrospective Studies Stent Thrombosis - pathology Thrombosis - therapy Ultrasonography, Interventional |
| title | Relation Between Plaque Components and Plaque Prolapse After Drug-Eluting Stent Implantation: Virtual Histology - Intravascular Ultrasound |
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