Mutational analysis of inhibin alpha gene revealed three novel variations in Indian women with premature ovarian failure

Objective To determine the prevalence of inhibin alpha gene variants in Indian women with premature ovarian failure. Design Mutational analysis of DNA from patients and control subjects. Setting Clinical genetics and molecular cytogenetic laboratory. Patients(s) One hundred 46,XX women with prematur...

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Veröffentlicht in:	Fertility and sterility 2010-06, Vol.94 (1), p.90-98
Hauptverfasser:	Prakash, Golla Jaya, Ph.D, Ravi Kanth, Vishnubhotla Venkata, Ph.D, Shelling, Andrew N., Ph.D, Rozati, Roya, M.D, Sujatha, Madireddi, Ph.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Diseases of mother, fetus and pregnancy DNA Mutational Analysis - methods DNA sequencing Female Genetic Variation - genetics Gynecology. Andrology. Obstetrics Humans India inhibin alpha (INHα) gene Inhibins - genetics Internal Medicine Medical sciences Molecular Sequence Data Mutation, Missense - genetics Obstetrics and Gynecology polymerase chain reaction (PCR) Pregnancy. Fetus. Placenta Premature ovarian failure (POF) Primary Ovarian Insufficiency - diagnosis Primary Ovarian Insufficiency - genetics Young Adult
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Zusammenfassung:	Objective To determine the prevalence of inhibin alpha gene variants in Indian women with premature ovarian failure. Design Mutational analysis of DNA from patients and control subjects. Setting Clinical genetics and molecular cytogenetic laboratory. Patients(s) One hundred 46,XX women with premature ovarian failure and 50 healthy control subjects
ISSN:	0015-0282 1556-5653
DOI:	10.1016/j.fertnstert.2009.02.014