Macromolecular diffusion characteristics of ageing human Bruch's membrane: Implications for age-related macular degeneration (AMD)

Macromolecular species such as retinal binding protein, transferrin, ceruloplasmin, etc., released by the fenestrated choroidal capillaries must diffuse across Bruch's membrane for interaction with the basal membranes of the retinal pigment epithelium (RPE) for delivery of essential metabolites...

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Veröffentlicht in:	Experimental eye research 2010-06, Vol.90 (6), p.703-710
Hauptverfasser:	Hussain, A.A., Starita, C., Hodgetts, A., Marshall, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over ageing Aging - physiology Biological Transport Bruch Membrane - metabolism Bruch's membrane Cell Membrane Permeability Child Child, Preschool Dextrans - metabolism Diffusion Fluorescein-5-isothiocyanate - analogs & derivatives Fluorescein-5-isothiocyanate - metabolism Humans Macromolecular Substances - metabolism macular degeneration Macular Degeneration - metabolism Middle Aged Tissue Donors
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Beschreibung
Zusammenfassung:	Macromolecular species such as retinal binding protein, transferrin, ceruloplasmin, etc., released by the fenestrated choroidal capillaries must diffuse across Bruch's membrane for interaction with the basal membranes of the retinal pigment epithelium (RPE) for delivery of essential metabolites to the neural retina. The patency of this pathway through ageing Bruch's was examined by quantifying the diffusional flux of a 21.2 kDa fluorescein-isothiocyanate labelled dextran. Dextran flux measurements across Bruch's membrane from the macular region of the human fundus showed a highly significant decrease ( p
ISSN:	0014-4835 1096-0007
DOI:	10.1016/j.exer.2010.02.013