Pentamidine uptake and resistance in pathogenic protozoa: past, present and future

Diamidines, and pentamidine in particular, have a long history as valuable chemotherapeutic agents against infectious disease. Their selectivity is due mostly to selective accumulation by the pathogen, rather than the host cell; and acquired resistance is frequently the result of changes in transmem...

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Veröffentlicht in:	Trends in parasitology 2003-05, Vol.19 (5), p.232-239
Hauptverfasser:	Bray, Patrick G., Barrett, Michael P., Ward, Stephen A., de Koning, Harry P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiprotozoal Agents - metabolism Antiprotozoal Agents - pharmacology Antiprotozoal Agents - therapeutic use Biochemistry. Physiology. Immunology. Molecular biology Biological and medical sciences Drug Resistance Fundamental and applied biological sciences. Psychology Humans Leishmania mexicana - drug effects Leishmania mexicana - metabolism Leishmaniasis, Cutaneous - drug therapy Malaria, Falciparum - drug therapy Malaria, Falciparum - prevention & control Pentamidine - metabolism Pentamidine - pharmacology Pentamidine - therapeutic use Plasmodium falciparum - drug effects Plasmodium falciparum - metabolism Protozoa Trypanosoma brucei brucei - drug effects Trypanosoma brucei brucei - metabolism Trypanosomiasis, African - drug therapy Trypanosomiasis, African - prevention & control
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