ATP-sensitive potassium channels in rat primary afferent neurons: the effect of neuropathic injury and gabapentin

ATP-sensitive potassium (K ATP) currents were examined in dorsal root ganglion neurons from neuropathic and control rats using whole-cell voltage clamp recordings. K ATP channel openers (diazoxide and pinacidil) enhanced, and the blocker glibenclamide inhibited an outward current in control neurons...

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Veröffentlicht in:	Neuroscience letters 2003-06, Vol.343 (3), p.185-189
Hauptverfasser:	Sarantopoulos, Constantine, McCallum, Bruce, Sapunar, Damir, Kwok, Wai-Meng, Hogan, Quinn
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - pharmacology Amines Animals ATP-Binding Cassette Transporters ATP-sensitive potassium channels Basal Ganglia - cytology Basal Ganglia - drug effects Basal Ganglia - physiology Biological and medical sciences Chronic constriction injury Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction Cyclohexanecarboxylic Acids Diazoxide Diazoxide - pharmacology Excitatory Amino Acid Antagonists - pharmacology Gabapentin gamma-Aminobutyric Acid Ganglia, Spinal - cytology Ganglia, Spinal - drug effects Glibenclamide Glyburide - pharmacology KATP Channels Male Medical sciences Nervous system (semeiology, syndromes) Neurology Neurons, Afferent - drug effects Neuropathy Neuroprotective Agents - pharmacology Pain - physiopathology Peripheral Nervous System Diseases - pathology Pinacidil Pinacidil - pharmacology Potassium Channel Blockers - pharmacology Potassium Channels - agonists Potassium Channels - drug effects Potassium Channels - physiology Potassium Channels, Inwardly Rectifying Primary afferent neurons Rats Rats, Sprague-Dawley
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