N-[ 18F]fluoroethyl-4-piperidyl acetate ([ 18F]FEtP4A) : A PET tracer for imaging brain acetylcholinesterase in vivo

N-[ 18F]Fluoroethyl-4-piperidyl acetate ([ 18F]FEtP4A) was synthesized and evaluated as a PET tracer for imaging brain acetylcholinesterase (AchE) in vivo. [ 18F]FEtP4A was previously prepared by reacting 4-piperidyl acetate (P4A) with 2-[ 18F]fluoroethyl bromide ([ 18F]FEtBr) at 130 °C for 30 min i...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry 2003-06, Vol.11 (12), p.2519-2527
Hauptverfasser:	Zhang, Ming-Rong, Furutsuka, Kenji, Maeda, Jun, Kikuchi, Tatsuya, Kida, Takayo, Okauchi, Takashi, Irie, Toshiaki, Suzuki, Kazutoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - chemical synthesis Acetates - pharmacokinetics Acetylcholinesterase - metabolism Animals Autoradiography Biological and medical sciences Brain - diagnostic imaging Brain - enzymology Carbon Radioisotopes Contrast media. Radiopharmaceuticals Fluorine Radioisotopes Hydrolysis Macaca mulatta Male Medical sciences Pharmacology. Drug treatments Piperidines - chemical synthesis Piperidines - pharmacokinetics Radiopharmaceuticals - chemical synthesis Rats Sensitivity and Specificity Tomography, Emission-Computed
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!