Decreased catabolism of fluorouracil in peripheral blood mononuclear cells during combination therapy with fluorouracil, leucovorin, and interferon alpha-2a

We previously reported that recombinant interferon alpha-2a (IFN alpha-2a) therapy was associated with a dose-dependent decrease in fluorouracil (5-FU) clearance. In this study, we used peripheral blood mononuclear cells (PBMCs), which are responsive to IFNs, as surrogate tissue to determine whether...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 1992-12, Vol.84 (23), p.1820-1825
Hauptverfasser:	Yee, L K, Allegra, C J, Steinberg, S M, Grem, J L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - blood Adenocarcinoma - drug therapy Antineoplastic Combined Chemotherapy Protocols - therapeutic use Chromatography, High Pressure Liquid Cytosol - metabolism Digestive System Neoplasms - blood Digestive System Neoplasms - drug therapy Dihydrouracil Dehydrogenase (NADP) Drug Administration Schedule Erythrocytes - enzymology Fluorouracil - administration & dosage Fluorouracil - pharmacokinetics Humans Interferon alpha-2 Interferon-alpha - administration & dosage Leucovorin - administration & dosage Leukocytes, Mononuclear - enzymology Leukocytes, Mononuclear - metabolism Oxidoreductases - blood Recombinant Proteins
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