Leukemia inhibitory factor and interleukin-11 promote maturation of murine and human megakaryocytes in vitro

The growth‐promoting activities of optimally stimulating concentrations of leukemia inhibitory factor (LIF) and interleukin‐11 (IL‐11), a stromal cell‐derived cytokine, on megakaryocytes in liquid marrow cultures were compared to interleukin‐6 (IL‐6), a known megakaryocytic maturation factor. Maxima...

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Veröffentlicht in:	Journal of cellular physiology 1992-11, Vol.153 (2), p.305-312
Hauptverfasser:	Burstein, Samuel A., Mei, Rui-Lian, Henthorn, James, Friese, Paul, Turner, Katherine
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase - metabolism Animals Biological and medical sciences Cell Count - drug effects Cell differentiation, maturation, development, hematopoiesis Cell physiology Cell Separation Cells, Cultured Cellular Senescence - drug effects Fundamental and applied biological sciences. Psychology Growth Inhibitors - pharmacology Humans Interleukin-11 - pharmacology Interleukin-3 - pharmacology Interleukin-6 - pharmacology Leukemia Inhibitory Factor Lymphokines - pharmacology Megakaryocytes - drug effects Megakaryocytes - metabolism Megakaryocytes - physiology Mice Molecular and cellular biology Ploidies
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