Fetal and neonatal leukemia
The biological and clinical characteristics of perinatal leukemia differ significantly from those of leukemia in older children, and the prognosis is generally bleak. Once complete remission is achieved, neonates with acute myelocytic leukemia (AML) fare much better than those with acute lymphocytic...
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| Veröffentlicht in: | Journal of pediatric hematology/oncology 2003-05, Vol.25 (5), p.348-361 |
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| container_title | Journal of pediatric hematology/oncology |
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| creator | ISAACS, Hart JR |
| description | The biological and clinical characteristics of perinatal leukemia differ significantly from those of leukemia in older children, and the prognosis is generally bleak. Once complete remission is achieved, neonates with acute myelocytic leukemia (AML) fare much better than those with acute lymphocytic leukemia (ALL). The results of this study suggest that age, sex, type of leukemia, and cytogenetic findings have a strong influence on outcome. Neonates, particularly females, with pre-B ALL have a much worse prognosis than neonates and older children with this disease. Transient leukemia in the Down syndrome neonate is associated with significant morbidity; close follow-up is recommended for at least the first 3 years of life because of the potential of developing acute leukemia, particularly AMKL (M7). The purpose of this review is to focus on the fetus and neonate in an attempt to determine the various ways leukemia differs clinically and morphologically from the disease occurring in older infants and children and to demonstrate that certain types of leukemia have a poor prognosis compared with those occurring in older children. |
| doi_str_mv | 10.1097/00043426-200305000-00002 |
| format | Article |
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Once complete remission is achieved, neonates with acute myelocytic leukemia (AML) fare much better than those with acute lymphocytic leukemia (ALL). The results of this study suggest that age, sex, type of leukemia, and cytogenetic findings have a strong influence on outcome. Neonates, particularly females, with pre-B ALL have a much worse prognosis than neonates and older children with this disease. Transient leukemia in the Down syndrome neonate is associated with significant morbidity; close follow-up is recommended for at least the first 3 years of life because of the potential of developing acute leukemia, particularly AMKL (M7). The purpose of this review is to focus on the fetus and neonate in an attempt to determine the various ways leukemia differs clinically and morphologically from the disease occurring in older infants and children and to demonstrate that certain types of leukemia have a poor prognosis compared with those occurring in older children.</description><identifier>ISSN: 1077-4114</identifier><identifier>EISSN: 1536-3678</identifier><identifier>DOI: 10.1097/00043426-200305000-00002</identifier><identifier>PMID: 12759620</identifier><identifier>CODEN: JPHOFG</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Biological and medical sciences ; Cytogenetics ; Diagnosis, Differential ; Down Syndrome ; Fetus - pathology ; Hematologic and hematopoietic diseases ; Humans ; Incidence ; Infant, Newborn ; Leukemia - diagnosis ; Leukemia - epidemiology ; Leukemia - etiology ; Leukemia - genetics ; Leukemias. Malignant lymphomas. Malignant reticulosis. 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Once complete remission is achieved, neonates with acute myelocytic leukemia (AML) fare much better than those with acute lymphocytic leukemia (ALL). The results of this study suggest that age, sex, type of leukemia, and cytogenetic findings have a strong influence on outcome. Neonates, particularly females, with pre-B ALL have a much worse prognosis than neonates and older children with this disease. Transient leukemia in the Down syndrome neonate is associated with significant morbidity; close follow-up is recommended for at least the first 3 years of life because of the potential of developing acute leukemia, particularly AMKL (M7). The purpose of this review is to focus on the fetus and neonate in an attempt to determine the various ways leukemia differs clinically and morphologically from the disease occurring in older infants and children and to demonstrate that certain types of leukemia have a poor prognosis compared with those occurring in older children.</description><subject>Biological and medical sciences</subject><subject>Cytogenetics</subject><subject>Diagnosis, Differential</subject><subject>Down Syndrome</subject><subject>Fetus - pathology</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infant, Newborn</subject><subject>Leukemia - diagnosis</subject><subject>Leukemia - epidemiology</subject><subject>Leukemia - etiology</subject><subject>Leukemia - genetics</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. 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Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Medical sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ISAACS, Hart JR</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric hematology/oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ISAACS, Hart JR</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fetal and neonatal leukemia</atitle><jtitle>Journal of pediatric hematology/oncology</jtitle><addtitle>J Pediatr Hematol Oncol</addtitle><date>2003-05-01</date><risdate>2003</risdate><volume>25</volume><issue>5</issue><spage>348</spage><epage>361</epage><pages>348-361</pages><issn>1077-4114</issn><eissn>1536-3678</eissn><coden>JPHOFG</coden><abstract>The biological and clinical characteristics of perinatal leukemia differ significantly from those of leukemia in older children, and the prognosis is generally bleak. Once complete remission is achieved, neonates with acute myelocytic leukemia (AML) fare much better than those with acute lymphocytic leukemia (ALL). The results of this study suggest that age, sex, type of leukemia, and cytogenetic findings have a strong influence on outcome. Neonates, particularly females, with pre-B ALL have a much worse prognosis than neonates and older children with this disease. Transient leukemia in the Down syndrome neonate is associated with significant morbidity; close follow-up is recommended for at least the first 3 years of life because of the potential of developing acute leukemia, particularly AMKL (M7). The purpose of this review is to focus on the fetus and neonate in an attempt to determine the various ways leukemia differs clinically and morphologically from the disease occurring in older infants and children and to demonstrate that certain types of leukemia have a poor prognosis compared with those occurring in older children.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>12759620</pmid><doi>10.1097/00043426-200305000-00002</doi><tpages>14</tpages></addata></record> |
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| identifier | ISSN: 1077-4114 |
| ispartof | Journal of pediatric hematology/oncology, 2003-05, Vol.25 (5), p.348-361 |
| issn | 1077-4114 1536-3678 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Biological and medical sciences Cytogenetics Diagnosis, Differential Down Syndrome Fetus - pathology Hematologic and hematopoietic diseases Humans Incidence Infant, Newborn Leukemia - diagnosis Leukemia - epidemiology Leukemia - etiology Leukemia - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences |
| title | Fetal and neonatal leukemia |
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