Cervical node metastases in squamous cell carcinoma of the upper aerodigestive tract: The significance of extracapsular spread and soft tissue deposits
Background. Literature regarding the prognostic significance of extracapsular spread and soft tissue deposits in cervical lymph node metastases of squamous cell carcinoma of the upper aerodigestive tract shows variable results. Methods. We analyzed 215 prospectively collected neck dissections from 1...
Gespeichert in:
| Veröffentlicht in: | Head & neck 2003-06, Vol.25 (6), p.451-456 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 456 |
|---|---|
| container_issue | 6 |
| container_start_page | 451 |
| container_title | Head & neck |
| container_volume | 25 |
| creator | Jose, Jemy Coatesworth, Andrew P. Johnston, Colin MacLennan, Ken |
| description | Background.
Literature regarding the prognostic significance of extracapsular spread and soft tissue deposits in cervical lymph node metastases of squamous cell carcinoma of the upper aerodigestive tract shows variable results.
Methods.
We analyzed 215 prospectively collected neck dissections from 155 patients with upper aerodigestive tract squamous cell carcinoma to assess the prevalence of extracapsular spread and soft tissue deposits and to assess their effect on survival.
Results.
Both extracapsular spread and soft tissue deposits significantly reduced survival (actuarial and recurrence free) compared with pN0 necks (p < .001) and pN+ve necks without extracapsular spread (p < .0025). There was no statistically significant difference between pN+ve necks without soft tissue deposits or extracapsular spread compared with those with pN0 necks (p = .24). Multivariate analysis revealed comparable results.
Conclusions.
Microscopic and macroscopic extracapsular spread and soft tissue deposits are of prognostic significance for survival and recurrence‐free survival in patients with upper aerodigestive tract squamous cell carcinoma. © 2003 Wiley Periodicals, Inc. Head Neck 25: 451–456, 2003 |
| doi_str_mv | 10.1002/hed.10214 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73303587</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>73303587</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4554-c0e91fb399473dffca7c4557895596313c158a76c16952a82d69daad79033e2c3</originalsourceid><addsrcrecordid>eNp1kctu1TAQhiMEoqWw4AWQNyCxCLVjJ07YVYe2B6nAgoOQ2FhTe9wacqsn6eVJ-ro4nENZIVnyaOabGf3zZ9lLwd8JzovDS3QpKIR6lO0L3uicS6UfL7GSueRa7WXPiH5yzmWliqfZnih0rQpZ7Wf3K4zXwULL-sEh63ACSg-JhZ7R1QzdMBOz2LbMQrShHzpgg2fTJbJ5HDEywDi4cIE0hWtkUwQ7vWebVKZw0QefZvcWlxa8XYow0txCZDRGBMegd4wGP7EpEM3IHI4DhYmeZ088tIQvdv9B9u3keLNa52dfTj-ujs5yq8pS5ZZjI_y5bBqlpfPegl4Kum7KsqmkkFaUNejKiqopC6gLVzUOwOmGS4mFlQfZm-3cMQ5XcxJhukCLXOgxKTdaSi7LWifw7Ra0cSCK6M0YQwfxzghuFhdMcsH8cSGxr3ZD5_MuZR_I3dkT8HoHAKXb-5huFOgfp2peC7Fwh1vuJrR49_-NZn384e_qfNsRaMLbhw6Iv0ylpS7N98-nZrOq6k9fT36YtfwNdrSvvA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>73303587</pqid></control><display><type>article</type><title>Cervical node metastases in squamous cell carcinoma of the upper aerodigestive tract: The significance of extracapsular spread and soft tissue deposits</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Jose, Jemy ; Coatesworth, Andrew P. ; Johnston, Colin ; MacLennan, Ken</creator><creatorcontrib>Jose, Jemy ; Coatesworth, Andrew P. ; Johnston, Colin ; MacLennan, Ken</creatorcontrib><description>Background.
Literature regarding the prognostic significance of extracapsular spread and soft tissue deposits in cervical lymph node metastases of squamous cell carcinoma of the upper aerodigestive tract shows variable results.
Methods.
We analyzed 215 prospectively collected neck dissections from 155 patients with upper aerodigestive tract squamous cell carcinoma to assess the prevalence of extracapsular spread and soft tissue deposits and to assess their effect on survival.
Results.
Both extracapsular spread and soft tissue deposits significantly reduced survival (actuarial and recurrence free) compared with pN0 necks (p < .001) and pN+ve necks without extracapsular spread (p < .0025). There was no statistically significant difference between pN+ve necks without soft tissue deposits or extracapsular spread compared with those with pN0 necks (p = .24). Multivariate analysis revealed comparable results.
Conclusions.
Microscopic and macroscopic extracapsular spread and soft tissue deposits are of prognostic significance for survival and recurrence‐free survival in patients with upper aerodigestive tract squamous cell carcinoma. © 2003 Wiley Periodicals, Inc. Head Neck 25: 451–456, 2003</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.10214</identifier><identifier>PMID: 12784236</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Biological and medical sciences ; carcinoma ; carcinoma, squamous cell ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - surgery ; head and neck neoplasms ; Humans ; Laryngeal Neoplasms - pathology ; Laryngeal Neoplasms - surgery ; Lymphatic Metastasis ; Medical sciences ; Neck Dissection ; Otorhinolaryngology. Stomatology ; Pharyngeal Neoplasms - pathology ; Pharyngeal Neoplasms - surgery ; Prognosis ; Proportional Hazards Models ; Prospective Studies ; Soft Tissue Neoplasms - secondary ; squamous cell ; Survival Analysis ; Tumors ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>Head & neck, 2003-06, Vol.25 (6), p.451-456</ispartof><rights>Copyright © 2003 Wiley Periodicals, Inc.</rights><rights>2003 INIST-CNRS</rights><rights>Copyright 2003 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4554-c0e91fb399473dffca7c4557895596313c158a76c16952a82d69daad79033e2c3</citedby><cites>FETCH-LOGICAL-c4554-c0e91fb399473dffca7c4557895596313c158a76c16952a82d69daad79033e2c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.10214$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.10214$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14808116$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12784236$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jose, Jemy</creatorcontrib><creatorcontrib>Coatesworth, Andrew P.</creatorcontrib><creatorcontrib>Johnston, Colin</creatorcontrib><creatorcontrib>MacLennan, Ken</creatorcontrib><title>Cervical node metastases in squamous cell carcinoma of the upper aerodigestive tract: The significance of extracapsular spread and soft tissue deposits</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background.
Literature regarding the prognostic significance of extracapsular spread and soft tissue deposits in cervical lymph node metastases of squamous cell carcinoma of the upper aerodigestive tract shows variable results.
Methods.
We analyzed 215 prospectively collected neck dissections from 155 patients with upper aerodigestive tract squamous cell carcinoma to assess the prevalence of extracapsular spread and soft tissue deposits and to assess their effect on survival.
Results.
Both extracapsular spread and soft tissue deposits significantly reduced survival (actuarial and recurrence free) compared with pN0 necks (p < .001) and pN+ve necks without extracapsular spread (p < .0025). There was no statistically significant difference between pN+ve necks without soft tissue deposits or extracapsular spread compared with those with pN0 necks (p = .24). Multivariate analysis revealed comparable results.
Conclusions.
Microscopic and macroscopic extracapsular spread and soft tissue deposits are of prognostic significance for survival and recurrence‐free survival in patients with upper aerodigestive tract squamous cell carcinoma. © 2003 Wiley Periodicals, Inc. Head Neck 25: 451–456, 2003</description><subject>Biological and medical sciences</subject><subject>carcinoma</subject><subject>carcinoma, squamous cell</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>head and neck neoplasms</subject><subject>Humans</subject><subject>Laryngeal Neoplasms - pathology</subject><subject>Laryngeal Neoplasms - surgery</subject><subject>Lymphatic Metastasis</subject><subject>Medical sciences</subject><subject>Neck Dissection</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Pharyngeal Neoplasms - pathology</subject><subject>Pharyngeal Neoplasms - surgery</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Soft Tissue Neoplasms - secondary</subject><subject>squamous cell</subject><subject>Survival Analysis</subject><subject>Tumors</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctu1TAQhiMEoqWw4AWQNyCxCLVjJ07YVYe2B6nAgoOQ2FhTe9wacqsn6eVJ-ro4nENZIVnyaOabGf3zZ9lLwd8JzovDS3QpKIR6lO0L3uicS6UfL7GSueRa7WXPiH5yzmWliqfZnih0rQpZ7Wf3K4zXwULL-sEh63ACSg-JhZ7R1QzdMBOz2LbMQrShHzpgg2fTJbJ5HDEywDi4cIE0hWtkUwQ7vWebVKZw0QefZvcWlxa8XYow0txCZDRGBMegd4wGP7EpEM3IHI4DhYmeZ088tIQvdv9B9u3keLNa52dfTj-ujs5yq8pS5ZZjI_y5bBqlpfPegl4Kum7KsqmkkFaUNejKiqopC6gLVzUOwOmGS4mFlQfZm-3cMQ5XcxJhukCLXOgxKTdaSi7LWifw7Ra0cSCK6M0YQwfxzghuFhdMcsH8cSGxr3ZD5_MuZR_I3dkT8HoHAKXb-5huFOgfp2peC7Fwh1vuJrR49_-NZn384e_qfNsRaMLbhw6Iv0ylpS7N98-nZrOq6k9fT36YtfwNdrSvvA</recordid><startdate>200306</startdate><enddate>200306</enddate><creator>Jose, Jemy</creator><creator>Coatesworth, Andrew P.</creator><creator>Johnston, Colin</creator><creator>MacLennan, Ken</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>John Wiley & Sons</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200306</creationdate><title>Cervical node metastases in squamous cell carcinoma of the upper aerodigestive tract: The significance of extracapsular spread and soft tissue deposits</title><author>Jose, Jemy ; Coatesworth, Andrew P. ; Johnston, Colin ; MacLennan, Ken</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4554-c0e91fb399473dffca7c4557895596313c158a76c16952a82d69daad79033e2c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Biological and medical sciences</topic><topic>carcinoma</topic><topic>carcinoma, squamous cell</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>head and neck neoplasms</topic><topic>Humans</topic><topic>Laryngeal Neoplasms - pathology</topic><topic>Laryngeal Neoplasms - surgery</topic><topic>Lymphatic Metastasis</topic><topic>Medical sciences</topic><topic>Neck Dissection</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Pharyngeal Neoplasms - pathology</topic><topic>Pharyngeal Neoplasms - surgery</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Soft Tissue Neoplasms - secondary</topic><topic>squamous cell</topic><topic>Survival Analysis</topic><topic>Tumors</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jose, Jemy</creatorcontrib><creatorcontrib>Coatesworth, Andrew P.</creatorcontrib><creatorcontrib>Johnston, Colin</creatorcontrib><creatorcontrib>MacLennan, Ken</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jose, Jemy</au><au>Coatesworth, Andrew P.</au><au>Johnston, Colin</au><au>MacLennan, Ken</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cervical node metastases in squamous cell carcinoma of the upper aerodigestive tract: The significance of extracapsular spread and soft tissue deposits</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2003-06</date><risdate>2003</risdate><volume>25</volume><issue>6</issue><spage>451</spage><epage>456</epage><pages>451-456</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background.
Literature regarding the prognostic significance of extracapsular spread and soft tissue deposits in cervical lymph node metastases of squamous cell carcinoma of the upper aerodigestive tract shows variable results.
Methods.
We analyzed 215 prospectively collected neck dissections from 155 patients with upper aerodigestive tract squamous cell carcinoma to assess the prevalence of extracapsular spread and soft tissue deposits and to assess their effect on survival.
Results.
Both extracapsular spread and soft tissue deposits significantly reduced survival (actuarial and recurrence free) compared with pN0 necks (p < .001) and pN+ve necks without extracapsular spread (p < .0025). There was no statistically significant difference between pN+ve necks without soft tissue deposits or extracapsular spread compared with those with pN0 necks (p = .24). Multivariate analysis revealed comparable results.
Conclusions.
Microscopic and macroscopic extracapsular spread and soft tissue deposits are of prognostic significance for survival and recurrence‐free survival in patients with upper aerodigestive tract squamous cell carcinoma. © 2003 Wiley Periodicals, Inc. Head Neck 25: 451–456, 2003</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>12784236</pmid><doi>10.1002/hed.10214</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1043-3074 |
| ispartof | Head & neck, 2003-06, Vol.25 (6), p.451-456 |
| issn | 1043-3074 1097-0347 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73303587 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Biological and medical sciences carcinoma carcinoma, squamous cell Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - surgery head and neck neoplasms Humans Laryngeal Neoplasms - pathology Laryngeal Neoplasms - surgery Lymphatic Metastasis Medical sciences Neck Dissection Otorhinolaryngology. Stomatology Pharyngeal Neoplasms - pathology Pharyngeal Neoplasms - surgery Prognosis Proportional Hazards Models Prospective Studies Soft Tissue Neoplasms - secondary squamous cell Survival Analysis Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Cervical node metastases in squamous cell carcinoma of the upper aerodigestive tract: The significance of extracapsular spread and soft tissue deposits |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T00%3A27%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cervical%20node%20metastases%20in%20squamous%20cell%20carcinoma%20of%20the%20upper%20aerodigestive%20tract:%20The%20significance%20of%20extracapsular%20spread%20and%20soft%20tissue%20deposits&rft.jtitle=Head%20&%20neck&rft.au=Jose,%20Jemy&rft.date=2003-06&rft.volume=25&rft.issue=6&rft.spage=451&rft.epage=456&rft.pages=451-456&rft.issn=1043-3074&rft.eissn=1097-0347&rft_id=info:doi/10.1002/hed.10214&rft_dat=%3Cproquest_cross%3E73303587%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=73303587&rft_id=info:pmid/12784236&rfr_iscdi=true |