A novel B cell-derived coactivator potentiates the activation of immunoglobulin promoters by octamer-binding transcription factors

A novel B cell-restricted activity, required for high levels of octamer/Oct-dependent transcription from an immunoglobulin heavy chain (IgH) promoter, was detected in an in vitro system consisting of HeLa cell-derived extracts complemented with fractionated B cell nuclear proteins. The factor respon...

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Veröffentlicht in:	Cell 1992-10, Vol.71 (2), p.231-241
Hauptverfasser:	Luo, Yan, Fujii, Hiroshi, Gerster, Thomas, Roeder, Robert G.
Format:	Artikel
Sprache:	eng
Schlagworte:	B-Lymphocytes - metabolism Base Sequence Biological and medical sciences DNA-Binding Proteins Fundamental and applied biological sciences. Psychology Host Cell Factor C1 Humans Immunoglobulins - genetics Molecular and cellular biology Molecular genetics Molecular Sequence Data Octamer Transcription Factor-1 Octamer Transcription Factor-2 Promoter Regions, Genetic Trans-Activators - genetics Trans-Activators - isolation & purification Transcription Factors Transcription. Transcription factor. Splicing. Rna processing Transcriptional Activation
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