Synthesis and Antihypertensive Activity of 1, 4-Dihydropyridine Derivatives with a 4-(Disubstituted Phenyl) Ring and an Aminoalkyl Ester Group : Highly Potent and Long-Lasting Calcium Antagonists

New 1, 4-dihydropyridine derivatives bearing a 4-(disubstituted phenyl) ring and an aminoethyl ester or an amino-2, 2-dimethylpropyl ester were synthesized and their antihypertensive activities were examined in normotensive rats and spontaneously hypertensive rats. The effects of phenyl substituents...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1992/08/25, Vol.40(8), pp.2049-2054
Hauptverfasser:	KANNO, Hideo, YAMAGUCHI, Hisao, OKAMIYA, Yoshiaki, SUNAKAWA, Kiyotaka, TAKESHITA, Toru, NARUCHI, Tatsuyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	1, 4-dihydropyridine derivative Animals antihypertensive activity Antihypertensive Agents - chemical synthesis Antihypertensive Agents - pharmacology calcium antagonist Calcium Channel Blockers - chemical synthesis Calcium Channel Blockers - pharmacology Chemistry Dihydropyridines - chemical synthesis Dihydropyridines - pharmacology disubstituted phenyl group Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives Male Organic chemistry Preparations and properties Rats Rats, Inbred SHR Rats, Wistar spontaneously hypertensive rat Structure-Activity Relationship
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