Evaluation of S-[ 11C]citalopram as a radioligand for in vivo labelling of 5-hydroxytryptamine uptake sites
The biologically active S-enantiomer of [ N-methyl- 11C]citalopram was evaluated as a radioligand for in vivo labelling of the 5-hydroxytryptamine uptake site in brain, using ex vivo tissue counting in rats and positron emission tomography in man. In rats, the maximal signal for total versus non-spe...
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| Veröffentlicht in: | International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology Nuclear medicine and biology, 1992-11, Vol.19 (8), p.851-855 |
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| container_end_page | 855 |
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| container_title | International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology |
| container_volume | 19 |
| creator | Hume, S.P. Lammertsma, A.A. Bench, C.J. Pike, V.W. Pascali, C. Cremer, J.E. Dolan, R.J. |
| description | The biologically active
S-enantiomer of [
N-methyl-
11C]citalopram was evaluated as a radioligand for
in vivo labelling of the 5-hydroxytryptamine uptake site in brain, using
ex vivo tissue counting in rats and positron emission tomography in man. In rats, the maximal signal for total versus non-specific binding was approx. 2 at 60–120 min after radioligand injection. Subsequent studies in man failed to identify a specific signal over a 90 min scanning period, due to prolonged retention of non-specific label. |
| doi_str_mv | 10.1016/0883-2897(92)90171-T |
| format | Article |
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S-enantiomer of [
N-methyl-
11C]citalopram was evaluated as a radioligand for
in vivo labelling of the 5-hydroxytryptamine uptake site in brain, using
ex vivo tissue counting in rats and positron emission tomography in man. In rats, the maximal signal for total versus non-specific binding was approx. 2 at 60–120 min after radioligand injection. Subsequent studies in man failed to identify a specific signal over a 90 min scanning period, due to prolonged retention of non-specific label.</description><identifier>ISSN: 0883-2897</identifier><identifier>DOI: 10.1016/0883-2897(92)90171-T</identifier><identifier>PMID: 1428913</identifier><identifier>CODEN: NMBIEO</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Biological and medical sciences ; Brain - metabolism ; Carbon Radioisotopes ; Citalopram - metabolism ; Contrast media. Radiopharmaceuticals ; Male ; Medical sciences ; Pharmacology. Drug treatments ; Radioligand Assay ; Rats ; Rats, Sprague-Dawley ; Serotonin - metabolism ; Stereoisomerism ; Tomography, Emission-Computed</subject><ispartof>International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, 1992-11, Vol.19 (8), p.851-855</ispartof><rights>1992</rights><rights>1993 INIST-CNRS</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-d505646833193e4356bd3ce03c3dcc82b098b0b6dcf6e9c7ebc98dd7ddc4480c3</citedby><cites>FETCH-LOGICAL-c347t-d505646833193e4356bd3ce03c3dcc82b098b0b6dcf6e9c7ebc98dd7ddc4480c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4353285$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1428913$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hume, S.P.</creatorcontrib><creatorcontrib>Lammertsma, A.A.</creatorcontrib><creatorcontrib>Bench, C.J.</creatorcontrib><creatorcontrib>Pike, V.W.</creatorcontrib><creatorcontrib>Pascali, C.</creatorcontrib><creatorcontrib>Cremer, J.E.</creatorcontrib><creatorcontrib>Dolan, R.J.</creatorcontrib><title>Evaluation of S-[ 11C]citalopram as a radioligand for in vivo labelling of 5-hydroxytryptamine uptake sites</title><title>International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology</title><addtitle>Int J Rad Appl Instrum B</addtitle><description>The biologically active
S-enantiomer of [
N-methyl-
11C]citalopram was evaluated as a radioligand for
in vivo labelling of the 5-hydroxytryptamine uptake site in brain, using
ex vivo tissue counting in rats and positron emission tomography in man. In rats, the maximal signal for total versus non-specific binding was approx. 2 at 60–120 min after radioligand injection. Subsequent studies in man failed to identify a specific signal over a 90 min scanning period, due to prolonged retention of non-specific label.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Carbon Radioisotopes</subject><subject>Citalopram - metabolism</subject><subject>Contrast media. Radiopharmaceuticals</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Radioligand Assay</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Serotonin - metabolism</subject><subject>Stereoisomerism</subject><subject>Tomography, Emission-Computed</subject><issn>0883-2897</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1P3DAQhn2gopTyD4rkA6rgEOqPfNiXSmhFKRJSD11OVWU54wl1SeLFTlbsv6-3u4IbJ1szzzuaeQj5xNklZ7z-wpSShVC6OdfiQjPe8GJ5QI5eyu_Jh5T-MiZUWTWH5JCXucrlEXm8Xtt-tpMPIw0d_Vn8opwvfoOfbB9W0Q7UJmpptM6H3j_Y0dEuROpHuvbrQHvbYt_78WEbroo_GxfD82aKm9VkBz8infPnEWnyE6aP5F1n-4Qn-_eY3H-7Xi6-F3c_bm4XV3cFyLKZClexqi5rJSXXEktZ1a2TgEyCdABKtEyrlrW1g65GDQ22oJVzjXNQloqBPCafd3NXMTzNmCYz-AR5TztimJNppGRCCJ3BcgdCDClF7Mwq-sHGjeHMbL2arUCzFWi0MP-9mmWOne7nz-2A7jW0k5r7Z_u-TWD7LtoRfHrB8kVSqCpjX3cYZhdrj9Ek8DgCOh8RJuOCf3uPf4gnl0o</recordid><startdate>199211</startdate><enddate>199211</enddate><creator>Hume, S.P.</creator><creator>Lammertsma, A.A.</creator><creator>Bench, C.J.</creator><creator>Pike, V.W.</creator><creator>Pascali, C.</creator><creator>Cremer, J.E.</creator><creator>Dolan, R.J.</creator><general>Elsevier Ltd</general><general>Pergamon</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199211</creationdate><title>Evaluation of S-[ 11C]citalopram as a radioligand for in vivo labelling of 5-hydroxytryptamine uptake sites</title><author>Hume, S.P. ; Lammertsma, A.A. ; Bench, C.J. ; Pike, V.W. ; Pascali, C. ; Cremer, J.E. ; Dolan, R.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-d505646833193e4356bd3ce03c3dcc82b098b0b6dcf6e9c7ebc98dd7ddc4480c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Carbon Radioisotopes</topic><topic>Citalopram - metabolism</topic><topic>Contrast media. Radiopharmaceuticals</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Radioligand Assay</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Serotonin - metabolism</topic><topic>Stereoisomerism</topic><topic>Tomography, Emission-Computed</topic><toplevel>online_resources</toplevel><creatorcontrib>Hume, S.P.</creatorcontrib><creatorcontrib>Lammertsma, A.A.</creatorcontrib><creatorcontrib>Bench, C.J.</creatorcontrib><creatorcontrib>Pike, V.W.</creatorcontrib><creatorcontrib>Pascali, C.</creatorcontrib><creatorcontrib>Cremer, J.E.</creatorcontrib><creatorcontrib>Dolan, R.J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hume, S.P.</au><au>Lammertsma, A.A.</au><au>Bench, C.J.</au><au>Pike, V.W.</au><au>Pascali, C.</au><au>Cremer, J.E.</au><au>Dolan, R.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of S-[ 11C]citalopram as a radioligand for in vivo labelling of 5-hydroxytryptamine uptake sites</atitle><jtitle>International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology</jtitle><addtitle>Int J Rad Appl Instrum B</addtitle><date>1992-11</date><risdate>1992</risdate><volume>19</volume><issue>8</issue><spage>851</spage><epage>855</epage><pages>851-855</pages><issn>0883-2897</issn><coden>NMBIEO</coden><abstract>The biologically active
S-enantiomer of [
N-methyl-
11C]citalopram was evaluated as a radioligand for
in vivo labelling of the 5-hydroxytryptamine uptake site in brain, using
ex vivo tissue counting in rats and positron emission tomography in man. In rats, the maximal signal for total versus non-specific binding was approx. 2 at 60–120 min after radioligand injection. Subsequent studies in man failed to identify a specific signal over a 90 min scanning period, due to prolonged retention of non-specific label.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>1428913</pmid><doi>10.1016/0883-2897(92)90171-T</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0883-2897 |
| ispartof | International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, 1992-11, Vol.19 (8), p.851-855 |
| issn | 0883-2897 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Brain - metabolism Carbon Radioisotopes Citalopram - metabolism Contrast media. Radiopharmaceuticals Male Medical sciences Pharmacology. Drug treatments Radioligand Assay Rats Rats, Sprague-Dawley Serotonin - metabolism Stereoisomerism Tomography, Emission-Computed |
| title | Evaluation of S-[ 11C]citalopram as a radioligand for in vivo labelling of 5-hydroxytryptamine uptake sites |
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