Delineation of the regulated Variant Surface Glycoprotein gene expression site domain of Trypanosoma brucei

The African trypanosome Trypanosoma brucei is protected in the bloodstream of the mammalian host by a dense Variant Surface Glycoprotein (VSG) coat. Although an individual cell has hundreds of VSG genes, the active VSG is transcribed in a mutually exclusive fashion from one of about twenty telomeric...

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Veröffentlicht in:	Molecular and biochemical parasitology 2003-05, Vol.128 (2), p.147-156
Hauptverfasser:	Sheader, Karen, Berberof, Magali, Isobe, Tomoko, Borst, Piet, Rudenko, Gloria
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigenic variation Base Sequence Gene Expression Regulation Models, Genetic Molecular Sequence Data Mutation Protein Structure, Tertiary Regulated domain RNA, Ribosomal - analysis Telomere Transcription, Genetic Trypanosoma brucei Trypanosoma brucei brucei - cytology Trypanosoma brucei brucei - genetics Trypanosoma brucei brucei - metabolism Variant Surface Glycoprotein Variant Surface Glycoproteins, Trypanosoma - chemistry Variant Surface Glycoproteins, Trypanosoma - genetics Variant Surface Glycoproteins, Trypanosoma - metabolism VSG expression site
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