Genetic and environmental risk factors and their interactions for Parkinson’s disease in a Chinese population
The interaction between genetic and environmental factors for PD was examined in a Chinese population. It was found that although the intron 2 MAOB (GT) n repeat polymorphism was not associated with PD in the population, a relationship might have been masked by the “protective effect” of tea drinkin...
Gespeichert in:
| Veröffentlicht in: | Journal of clinical neuroscience 2003-05, Vol.10 (3), p.313-315 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 315 |
|---|---|
| container_issue | 3 |
| container_start_page | 313 |
| container_title | Journal of clinical neuroscience |
| container_volume | 10 |
| creator | Chan, D.K.Y. Mellick, G.D. Hung, W.T. Woo, J. |
| description | The interaction between genetic and environmental factors for PD was examined in a Chinese population. It was found that although the intron 2 MAOB (GT)
n
repeat polymorphism was not associated with PD in the population, a relationship might have been masked by the “protective effect” of tea drinking. In individuals who did not drink tea ( |
| doi_str_mv | 10.1016/S0967-5868(03)00014-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73297701</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0967586803000146</els_id><sourcerecordid>73297701</sourcerecordid><originalsourceid>FETCH-LOGICAL-c443t-76d2a53e4b0af6eb7d372f89be91850f8e099ef3b3d24b7c035b77e5f032109a3</originalsourceid><addsrcrecordid>eNqFkM2KFDEQx4Mo7rj6CEouih5a853u0yKDrsKCgnoO6XSFjduTjKmeBW--hq_nk5j5wD16CpX6_auKHyFPOXvNGTdvvrDB2E73pn_J5CvGGFeduUdWXEvRCaPlfbL6h5yRR4jfGzQoyR6SMy6skVLqFSmXkGFJgfo8Uci3qZa8gbz4mdaENzT6sJSKh_ZyDanSlBeo7TeVjDSWSj_7epMylvzn12-kU0LwCA2jnq6vU4ZWbMt2N_t95DF5EP2M8OT0npNv7999XX_orj5dfly_veqCUnLprJmE1xLUyHw0MNpJWhH7YYSB95rFHtgwQJSjnIQabWBSj9aCjkwKzgYvz8mL49xtLT92gIvbJAwwzz5D2aGzUgzWMt5AfQRDLYgVotvWtPH1p-PM7U27g2m31-iYdAfTzrTcs9OC3biB6S51UtuA5yfAY_BzrD6HhHec6sWgVN-4iyMHTcdtguowJMgBplQhLG4q6T-n_AX3o50o</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>73297701</pqid></control><display><type>article</type><title>Genetic and environmental risk factors and their interactions for Parkinson’s disease in a Chinese population</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Chan, D.K.Y. ; Mellick, G.D. ; Hung, W.T. ; Woo, J.</creator><creatorcontrib>Chan, D.K.Y. ; Mellick, G.D. ; Hung, W.T. ; Woo, J.</creatorcontrib><description>The interaction between genetic and environmental factors for PD was examined in a Chinese population. It was found that although the intron 2 MAOB (GT)
n
repeat polymorphism was not associated with PD in the population, a relationship might have been masked by the “protective effect” of tea drinking. In individuals who did not drink tea (<1 cup/day), the possession of short length ⩽178
bp (GT)
n
alleles conferred a borderline significant increased risk for PD (adjusted OR=1.47; C.I.=1.03–2.1). As the extent of tea consumption increased, the association between the ⩽178
bp allele and PD disappeared. This result suggests that the MAOB gene may be associated with PD in Chinese if the putative protective effect of tea drinking is taken into account. The significance of this finding is unclear as the study may be limited because of its marginal significance and limited numbers. However, it does demonstrate the importance of considering putative positive and negative environmental risk factors in any examination of genetic risk factors for PD.</description><identifier>ISSN: 0967-5868</identifier><identifier>EISSN: 1532-2653</identifier><identifier>DOI: 10.1016/S0967-5868(03)00014-6</identifier><identifier>PMID: 12763335</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Asian Continental Ancestry Group - genetics ; Biological and medical sciences ; China - epidemiology ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Diet ; Environment ; Feeding Behavior ; Humans ; Introns ; Life Style ; Medical sciences ; Microsatellite Repeats ; Monoamine Oxidase - genetics ; Neurology ; Odds Ratio ; Parkinson Disease - enzymology ; Parkinson Disease - epidemiology ; Parkinson Disease - genetics ; Polymorphism, Genetic ; Risk Factors ; Surveys and Questionnaires ; Tea</subject><ispartof>Journal of clinical neuroscience, 2003-05, Vol.10 (3), p.313-315</ispartof><rights>2003 Elsevier Science Ltd</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-76d2a53e4b0af6eb7d372f89be91850f8e099ef3b3d24b7c035b77e5f032109a3</citedby><cites>FETCH-LOGICAL-c443t-76d2a53e4b0af6eb7d372f89be91850f8e099ef3b3d24b7c035b77e5f032109a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0967-5868(03)00014-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14829448$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12763335$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chan, D.K.Y.</creatorcontrib><creatorcontrib>Mellick, G.D.</creatorcontrib><creatorcontrib>Hung, W.T.</creatorcontrib><creatorcontrib>Woo, J.</creatorcontrib><title>Genetic and environmental risk factors and their interactions for Parkinson’s disease in a Chinese population</title><title>Journal of clinical neuroscience</title><addtitle>J Clin Neurosci</addtitle><description>The interaction between genetic and environmental factors for PD was examined in a Chinese population. It was found that although the intron 2 MAOB (GT)
n
repeat polymorphism was not associated with PD in the population, a relationship might have been masked by the “protective effect” of tea drinking. In individuals who did not drink tea (<1 cup/day), the possession of short length ⩽178
bp (GT)
n
alleles conferred a borderline significant increased risk for PD (adjusted OR=1.47; C.I.=1.03–2.1). As the extent of tea consumption increased, the association between the ⩽178
bp allele and PD disappeared. This result suggests that the MAOB gene may be associated with PD in Chinese if the putative protective effect of tea drinking is taken into account. The significance of this finding is unclear as the study may be limited because of its marginal significance and limited numbers. However, it does demonstrate the importance of considering putative positive and negative environmental risk factors in any examination of genetic risk factors for PD.</description><subject>Asian Continental Ancestry Group - genetics</subject><subject>Biological and medical sciences</subject><subject>China - epidemiology</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Diet</subject><subject>Environment</subject><subject>Feeding Behavior</subject><subject>Humans</subject><subject>Introns</subject><subject>Life Style</subject><subject>Medical sciences</subject><subject>Microsatellite Repeats</subject><subject>Monoamine Oxidase - genetics</subject><subject>Neurology</subject><subject>Odds Ratio</subject><subject>Parkinson Disease - enzymology</subject><subject>Parkinson Disease - epidemiology</subject><subject>Parkinson Disease - genetics</subject><subject>Polymorphism, Genetic</subject><subject>Risk Factors</subject><subject>Surveys and Questionnaires</subject><subject>Tea</subject><issn>0967-5868</issn><issn>1532-2653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM2KFDEQx4Mo7rj6CEouih5a853u0yKDrsKCgnoO6XSFjduTjKmeBW--hq_nk5j5wD16CpX6_auKHyFPOXvNGTdvvrDB2E73pn_J5CvGGFeduUdWXEvRCaPlfbL6h5yRR4jfGzQoyR6SMy6skVLqFSmXkGFJgfo8Uci3qZa8gbz4mdaENzT6sJSKh_ZyDanSlBeo7TeVjDSWSj_7epMylvzn12-kU0LwCA2jnq6vU4ZWbMt2N_t95DF5EP2M8OT0npNv7999XX_orj5dfly_veqCUnLprJmE1xLUyHw0MNpJWhH7YYSB95rFHtgwQJSjnIQabWBSj9aCjkwKzgYvz8mL49xtLT92gIvbJAwwzz5D2aGzUgzWMt5AfQRDLYgVotvWtPH1p-PM7U27g2m31-iYdAfTzrTcs9OC3biB6S51UtuA5yfAY_BzrD6HhHec6sWgVN-4iyMHTcdtguowJMgBplQhLG4q6T-n_AX3o50o</recordid><startdate>20030501</startdate><enddate>20030501</enddate><creator>Chan, D.K.Y.</creator><creator>Mellick, G.D.</creator><creator>Hung, W.T.</creator><creator>Woo, J.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030501</creationdate><title>Genetic and environmental risk factors and their interactions for Parkinson’s disease in a Chinese population</title><author>Chan, D.K.Y. ; Mellick, G.D. ; Hung, W.T. ; Woo, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-76d2a53e4b0af6eb7d372f89be91850f8e099ef3b3d24b7c035b77e5f032109a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Asian Continental Ancestry Group - genetics</topic><topic>Biological and medical sciences</topic><topic>China - epidemiology</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Diet</topic><topic>Environment</topic><topic>Feeding Behavior</topic><topic>Humans</topic><topic>Introns</topic><topic>Life Style</topic><topic>Medical sciences</topic><topic>Microsatellite Repeats</topic><topic>Monoamine Oxidase - genetics</topic><topic>Neurology</topic><topic>Odds Ratio</topic><topic>Parkinson Disease - enzymology</topic><topic>Parkinson Disease - epidemiology</topic><topic>Parkinson Disease - genetics</topic><topic>Polymorphism, Genetic</topic><topic>Risk Factors</topic><topic>Surveys and Questionnaires</topic><topic>Tea</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chan, D.K.Y.</creatorcontrib><creatorcontrib>Mellick, G.D.</creatorcontrib><creatorcontrib>Hung, W.T.</creatorcontrib><creatorcontrib>Woo, J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chan, D.K.Y.</au><au>Mellick, G.D.</au><au>Hung, W.T.</au><au>Woo, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic and environmental risk factors and their interactions for Parkinson’s disease in a Chinese population</atitle><jtitle>Journal of clinical neuroscience</jtitle><addtitle>J Clin Neurosci</addtitle><date>2003-05-01</date><risdate>2003</risdate><volume>10</volume><issue>3</issue><spage>313</spage><epage>315</epage><pages>313-315</pages><issn>0967-5868</issn><eissn>1532-2653</eissn><abstract>The interaction between genetic and environmental factors for PD was examined in a Chinese population. It was found that although the intron 2 MAOB (GT)
n
repeat polymorphism was not associated with PD in the population, a relationship might have been masked by the “protective effect” of tea drinking. In individuals who did not drink tea (<1 cup/day), the possession of short length ⩽178
bp (GT)
n
alleles conferred a borderline significant increased risk for PD (adjusted OR=1.47; C.I.=1.03–2.1). As the extent of tea consumption increased, the association between the ⩽178
bp allele and PD disappeared. This result suggests that the MAOB gene may be associated with PD in Chinese if the putative protective effect of tea drinking is taken into account. The significance of this finding is unclear as the study may be limited because of its marginal significance and limited numbers. However, it does demonstrate the importance of considering putative positive and negative environmental risk factors in any examination of genetic risk factors for PD.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>12763335</pmid><doi>10.1016/S0967-5868(03)00014-6</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0967-5868 |
| ispartof | Journal of clinical neuroscience, 2003-05, Vol.10 (3), p.313-315 |
| issn | 0967-5868 1532-2653 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73297701 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Asian Continental Ancestry Group - genetics Biological and medical sciences China - epidemiology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Diet Environment Feeding Behavior Humans Introns Life Style Medical sciences Microsatellite Repeats Monoamine Oxidase - genetics Neurology Odds Ratio Parkinson Disease - enzymology Parkinson Disease - epidemiology Parkinson Disease - genetics Polymorphism, Genetic Risk Factors Surveys and Questionnaires Tea |
| title | Genetic and environmental risk factors and their interactions for Parkinson’s disease in a Chinese population |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T17%3A01%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Genetic%20and%20environmental%20risk%20factors%20and%20their%20interactions%20for%20Parkinson%E2%80%99s%20disease%20in%20a%20Chinese%20population&rft.jtitle=Journal%20of%20clinical%20neuroscience&rft.au=Chan,%20D.K.Y.&rft.date=2003-05-01&rft.volume=10&rft.issue=3&rft.spage=313&rft.epage=315&rft.pages=313-315&rft.issn=0967-5868&rft.eissn=1532-2653&rft_id=info:doi/10.1016/S0967-5868(03)00014-6&rft_dat=%3Cproquest_cross%3E73297701%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=73297701&rft_id=info:pmid/12763335&rft_els_id=S0967586803000146&rfr_iscdi=true |