Simultaneous determination of tenidap and its stable isotope analog in serum by high‐performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry

Simultaneous determination of tenidap and its stable isotope analog in serum by high‐performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry

A specific high‐performance liquid chromatographic/atmospheric pressure chemical ionization tandem mass spectrometric assay for the quantitative determination of tenidap and its D3 analog in human serum is described. The assay exhibited a linear dynamic range of 0.1‐25 μg ml−1. Its precision for the...

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Veröffentlicht in:Biological Mass Spectrometry 1992-07, Vol.21 (7), p.353-357
Hauptverfasser: Avery, M. J., Mitchell, D. Y., Falkner, F. C., Fouda, H. G.
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Sprache:eng
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Anti-Inflammatory Agents, Non-Steroidal - blood
Humans
Indoles - blood
Mass Spectrometry - methods
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container_end_page 357
container_issue 7
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container_title Biological Mass Spectrometry
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creator Avery, M. J.
Mitchell, D. Y.
Falkner, F. C.
Fouda, H. G.
description A specific high‐performance liquid chromatographic/atmospheric pressure chemical ionization tandem mass spectrometric assay for the quantitative determination of tenidap and its D3 analog in human serum is described. The assay exhibited a linear dynamic range of 0.1‐25 μg ml−1. Its precision for the two analytes over the range was 17% or better. The assay validity and its utility to investigate changes in tenidap bioequivalence and pharmacokinetics are presented.
doi_str_mv 10.1002/bms.1200210706
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subjects Anti-Inflammatory Agents, Non-Steroidal - blood
Humans
Indoles - blood
Mass Spectrometry - methods
title Simultaneous determination of tenidap and its stable isotope analog in serum by high‐performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry
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