Activation of PI3-Kinase Is Required for AMPA Receptor Insertion during LTP of mEPSCs in Cultured Hippocampal Neurons

Hippocampal CA1 homosynaptic long-term potentiation (LTP) is expressed specifically at activated synapses. Increased insertion of postsynaptic α-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid receptors (AMPARs) appears to be crucial for CA1 LTP. However, the mechanism underlying AMPAR insertion...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2003-05, Vol.38 (4), p.611-624
Hauptverfasser:	Man, Heng-Ye, Wang, Qinhua, Lu, Wei-Yang, Ju, William, Ahmadian, Gholamreza, Liu, Lidong, D'Souza, Sandra, Wong, T.P, Taghibiglou, C, Lu, Jie, Becker, Larry E, Pei, Lin, Liu, Fang, Wymann, Matthias P, MacDonald, John F, Wang, Yu Tian
Format:	Artikel
Sprache:	eng
Schlagworte:	Androstadienes - pharmacology Animals Biotechnology Cells, Cultured Chromones - pharmacology Enzyme Inhibitors - pharmacology Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Hippocampus - cytology Long-Term Potentiation - physiology Medical research Mice Morpholines - pharmacology Neuronal Plasticity - physiology Neurons Neurons - cytology Neurons - physiology Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - metabolism Protein Transport - physiology Proteins Rats Rats, Sprague-Dawley Receptors, AMPA - metabolism Signal Transduction - physiology Stroke Wortmannin
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