Once‐a‐Day Controlled‐Release Dosage form of Divalproex Sodium I: Formulation Design and in Vitro/in Vivo Investigations

Divalproex sodium is a narrow therapeutic index drug that is widely used for the treatment of epilepsy, the manic episodes associated with bipolar disorder, and prophylaxis of migraine headaches. The present investigation was undertaken to design an oral dosage form that would provide once‐daily adm...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmaceutical sciences 2003-06, Vol.92 (6), p.1166-1173
Hauptverfasser:	Qiu, Yihong, Cheskin, Howard S., Engh, Kevin R., Poska, Richard P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticonvulsants - administration & dosage Anticonvulsants - blood Anticonvulsants - pharmacokinetics Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Chemistry, Pharmaceutical controlled release Cross-Over Studies Delayed-Action Preparations divalproex sodium Dogs Drug Administration Schedule Drug Compounding Excipients Humans in vitro release In Vitro Techniques in vitro-in vivo relationship in vivo absorption Intestinal Absorption matrix system Medical sciences Methylcellulose Neuropharmacology Pharmacology. Drug treatments Tablets Time Factors Valproic Acid - administration & dosage Valproic Acid - blood Valproic Acid - pharmacokinetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!