Mutation spectrum of the p53 gene in bone and soft tissue sarcomas

We present here an analysis of the spectrum of mutations of the p53 gene seen in 127 bone and soft tissue sarcomas of various histological classifications. Gross rearrangements were analyzed by Southern blotting using a complementary DNA probe from the p53 gene, and subtle alterations in the entire...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1992-11, Vol.52 (22), p.6194-6199
Hauptverfasser:	TOGUCHIDA, J, YAMAGUCHI, T, WEICHSELBAUM, R. R, ISHIZAKI, K, YANDELL, D. W, RITCHIE, B, BEAUCHAMP, R. L, DAYTON, S. H, HERRERA, G. E, YAMAMURO, T, KOTOURA, Y, SASAKI, M. S, LITTLE, J. B
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Base Sequence Biological and medical sciences Blotting, Southern Bone Neoplasms - genetics Diseases of the osteoarticular system Exons - genetics Gene Deletion Gene Rearrangement - genetics Genes, p53 - genetics Humans Medical sciences Molecular Sequence Data Mutation Osteosarcoma - genetics Phenotype Sarcoma - genetics Soft Tissue Neoplasms - genetics Tumors of striated muscle and skeleton
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