Inhaled steroids modify bronchial responses to hyperosmolar saline
We investigated the effects of inhaled beclomethasone dipropionate (BDP) on airway sensitivity (provocative dose producing a 20% fall in forced expiratory volume in one second (FEV1) from baseline (PD20)) and reactivity (slope of the dose-response curve) to inhaled aerosols of hyperosmolar (4.5%) sa...
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| Veröffentlicht in: | The European respiratory journal 1992-09, Vol.5 (8), p.953-962 |
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| creator | Rodwell, LT Anderson, SD Seale, JP |
| description | We investigated the effects of inhaled beclomethasone dipropionate (BDP) on airway sensitivity (provocative dose producing a 20% fall in forced expiratory volume in one second (FEV1) from baseline (PD20)) and reactivity (slope of the dose-response curve) to inhaled aerosols of hyperosmolar (4.5%) saline, and histamine or methacholine. This was an open study on 13 patients referred to the laboratory by their respiratory physician for investigation of their asthma. These challenges were performed on separate days before (initial visit) and 8.8 +/- 0.8 (SD) weeks (range 5.6-12.4 weeks) after (visit 1) a treatment period with BDP (dose range 600-1,500 micrograms.day-1). At visit 1 there was a significant reduction in sensitivity to 4.5% NaCl and histamine/methacholine and in reactivity. The PD20 increased 5.6 fold for 4.5% NaCl and 4.1 fold for histamine/methacholine. All patients remained responsive to histamine/methacholine and a fall in FEV1 > 20% to 4.5% saline was documented in 10 of the 13 patients. We conclude that treatment with BDP reduces sensitivity and reactivity to both osmotic and pharmacological challenge. |
| doi_str_mv | 10.1183/09031936.93.05080953 |
| format | Article |
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This was an open study on 13 patients referred to the laboratory by their respiratory physician for investigation of their asthma. These challenges were performed on separate days before (initial visit) and 8.8 +/- 0.8 (SD) weeks (range 5.6-12.4 weeks) after (visit 1) a treatment period with BDP (dose range 600-1,500 micrograms.day-1). At visit 1 there was a significant reduction in sensitivity to 4.5% NaCl and histamine/methacholine and in reactivity. The PD20 increased 5.6 fold for 4.5% NaCl and 4.1 fold for histamine/methacholine. All patients remained responsive to histamine/methacholine and a fall in FEV1 > 20% to 4.5% saline was documented in 10 of the 13 patients. We conclude that treatment with BDP reduces sensitivity and reactivity to both osmotic and pharmacological challenge.</description><identifier>ISSN: 0903-1936</identifier><identifier>EISSN: 1399-3003</identifier><identifier>DOI: 10.1183/09031936.93.05080953</identifier><identifier>PMID: 1426203</identifier><language>eng</language><publisher>Leeds: Eur Respiratory Soc</publisher><subject>Administration, Inhalation ; Adolescent ; Adult ; Asthma - physiopathology ; Beclomethasone - administration & dosage ; Beclomethasone - pharmacology ; Biological and medical sciences ; Bronchi - drug effects ; Bronchial Provocation Tests - methods ; Dose-Response Relationship, Drug ; Female ; Forced Expiratory Volume - drug effects ; Histamine - pharmacology ; Humans ; Male ; Medical sciences ; Methacholine Chloride - pharmacology ; Osmolar Concentration ; Pharmacology. Drug treatments ; Pilot Projects ; Respiratory system ; Sodium Chloride - chemistry ; Sodium Chloride - pharmacology</subject><ispartof>The European respiratory journal, 1992-09, Vol.5 (8), p.953-962</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-eaf99226b067ef21a0bf62d01db7c7254e7bf420e912687800af96c0e1aa611d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4634858$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1426203$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rodwell, LT</creatorcontrib><creatorcontrib>Anderson, SD</creatorcontrib><creatorcontrib>Seale, JP</creatorcontrib><title>Inhaled steroids modify bronchial responses to hyperosmolar saline</title><title>The European respiratory journal</title><addtitle>Eur Respir J</addtitle><description>We investigated the effects of inhaled beclomethasone dipropionate (BDP) on airway sensitivity (provocative dose producing a 20% fall in forced expiratory volume in one second (FEV1) from baseline (PD20)) and reactivity (slope of the dose-response curve) to inhaled aerosols of hyperosmolar (4.5%) saline, and histamine or methacholine. This was an open study on 13 patients referred to the laboratory by their respiratory physician for investigation of their asthma. These challenges were performed on separate days before (initial visit) and 8.8 +/- 0.8 (SD) weeks (range 5.6-12.4 weeks) after (visit 1) a treatment period with BDP (dose range 600-1,500 micrograms.day-1). At visit 1 there was a significant reduction in sensitivity to 4.5% NaCl and histamine/methacholine and in reactivity. The PD20 increased 5.6 fold for 4.5% NaCl and 4.1 fold for histamine/methacholine. All patients remained responsive to histamine/methacholine and a fall in FEV1 > 20% to 4.5% saline was documented in 10 of the 13 patients. We conclude that treatment with BDP reduces sensitivity and reactivity to both osmotic and pharmacological challenge.</description><subject>Administration, Inhalation</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Asthma - physiopathology</subject><subject>Beclomethasone - administration & dosage</subject><subject>Beclomethasone - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Bronchi - drug effects</subject><subject>Bronchial Provocation Tests - methods</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Forced Expiratory Volume - drug effects</subject><subject>Histamine - pharmacology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methacholine Chloride - pharmacology</subject><subject>Osmolar Concentration</subject><subject>Pharmacology. Drug treatments</subject><subject>Pilot Projects</subject><subject>Respiratory system</subject><subject>Sodium Chloride - chemistry</subject><subject>Sodium Chloride - pharmacology</subject><issn>0903-1936</issn><issn>1399-3003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1LxDAQxYMoun78Bwo9iLeuM0mbNkcVv0DwoueQtlMbSds1s4vsf2-XXfU0A-_33gxPiHOEOWKprsGAQqP03Kg55FCCydWemKEyJlUAal_MNki6YY7EMfMnAOpM4aE4xExqCWombp-HzgVqEl5SHH3DST82vl0nVRyHuvMuJJF4MQ5MnCzHpFsvJo77MbiYsAt-oFNx0LrAdLabJ-L94f7t7il9eX18vrt5SesM9DIl1xojpa5AF9RKdFC1WjaATVXUhcwzKqo2k0AGpS6LEmAy6BoIndOIjToRV9vcRRy_VsRL23uuKQQ30LhiWyhpcjR6ArMtWE-fcqTWLqLvXVxbBLupzv5WZ82076qbbBe7_FXVU_Nv2nY16Zc73XHtQhvdUHv-wzKtsjIv_7HOf3TfPpLl3oUwhaKl-Jnb0m6u_QBAc4K8</recordid><startdate>19920901</startdate><enddate>19920901</enddate><creator>Rodwell, LT</creator><creator>Anderson, SD</creator><creator>Seale, JP</creator><general>Eur Respiratory Soc</general><general>Maney</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920901</creationdate><title>Inhaled steroids modify bronchial responses to hyperosmolar saline</title><author>Rodwell, LT ; Anderson, SD ; Seale, JP</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-eaf99226b067ef21a0bf62d01db7c7254e7bf420e912687800af96c0e1aa611d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Administration, Inhalation</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Asthma - physiopathology</topic><topic>Beclomethasone - administration & dosage</topic><topic>Beclomethasone - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Bronchi - drug effects</topic><topic>Bronchial Provocation Tests - methods</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Forced Expiratory Volume - drug effects</topic><topic>Histamine - pharmacology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methacholine Chloride - pharmacology</topic><topic>Osmolar Concentration</topic><topic>Pharmacology. Drug treatments</topic><topic>Pilot Projects</topic><topic>Respiratory system</topic><topic>Sodium Chloride - chemistry</topic><topic>Sodium Chloride - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rodwell, LT</creatorcontrib><creatorcontrib>Anderson, SD</creatorcontrib><creatorcontrib>Seale, JP</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The European respiratory journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rodwell, LT</au><au>Anderson, SD</au><au>Seale, JP</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhaled steroids modify bronchial responses to hyperosmolar saline</atitle><jtitle>The European respiratory journal</jtitle><addtitle>Eur Respir J</addtitle><date>1992-09-01</date><risdate>1992</risdate><volume>5</volume><issue>8</issue><spage>953</spage><epage>962</epage><pages>953-962</pages><issn>0903-1936</issn><eissn>1399-3003</eissn><abstract>We investigated the effects of inhaled beclomethasone dipropionate (BDP) on airway sensitivity (provocative dose producing a 20% fall in forced expiratory volume in one second (FEV1) from baseline (PD20)) and reactivity (slope of the dose-response curve) to inhaled aerosols of hyperosmolar (4.5%) saline, and histamine or methacholine. This was an open study on 13 patients referred to the laboratory by their respiratory physician for investigation of their asthma. These challenges were performed on separate days before (initial visit) and 8.8 +/- 0.8 (SD) weeks (range 5.6-12.4 weeks) after (visit 1) a treatment period with BDP (dose range 600-1,500 micrograms.day-1). At visit 1 there was a significant reduction in sensitivity to 4.5% NaCl and histamine/methacholine and in reactivity. The PD20 increased 5.6 fold for 4.5% NaCl and 4.1 fold for histamine/methacholine. All patients remained responsive to histamine/methacholine and a fall in FEV1 > 20% to 4.5% saline was documented in 10 of the 13 patients. We conclude that treatment with BDP reduces sensitivity and reactivity to both osmotic and pharmacological challenge.</abstract><cop>Leeds</cop><pub>Eur Respiratory Soc</pub><pmid>1426203</pmid><doi>10.1183/09031936.93.05080953</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0903-1936 |
| ispartof | The European respiratory journal, 1992-09, Vol.5 (8), p.953-962 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Administration, Inhalation Adolescent Adult Asthma - physiopathology Beclomethasone - administration & dosage Beclomethasone - pharmacology Biological and medical sciences Bronchi - drug effects Bronchial Provocation Tests - methods Dose-Response Relationship, Drug Female Forced Expiratory Volume - drug effects Histamine - pharmacology Humans Male Medical sciences Methacholine Chloride - pharmacology Osmolar Concentration Pharmacology. Drug treatments Pilot Projects Respiratory system Sodium Chloride - chemistry Sodium Chloride - pharmacology |
| title | Inhaled steroids modify bronchial responses to hyperosmolar saline |
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