Proteomic comparison between human young and old brains by two‐dimensional gel electrophoresis and identification of proteins

To investigate molecular mechanisms of human brain aging, brain proteins were isolated from postmortem human young and old brains and profiled by two‐dimensional gel electrophoresis (2‐DE). With the help of special software, five down‐regulated protein spots in two‐dimensional gel electrophoresis ge...

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Veröffentlicht in:	International journal of developmental neuroscience 2003-06, Vol.21 (4), p.209-216
Hauptverfasser:	Chen, Wen, Ji, Jianguo, Xu, Xiaoman, He, Sizhi, Ru, Binggen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Aging Aging - genetics Aging - metabolism Amino Acid Sequence Apolipoprotein A-I - metabolism Apolipoprotein A-I - physiology Brain Brain - embryology Brain - metabolism Brain - physiology Cadaver Cerebral Cortex - embryology Cerebral Cortex - metabolism Cerebral Cortex - physiology Electrophoresis, Gel, Two-Dimensional - methods Female Gene Expression Regulation, Developmental - physiology Humans In Vitro Techniques Male Mass spectrometry Microtubule Proteins Middle Aged Molecular Sequence Data Peroxidases - metabolism Peroxidases - physiology Peroxiredoxins Phosphoproteins - metabolism Phosphoproteins - physiology Proteins - metabolism Proteins - physiology Proteomics Proteomics - methods Sequence Analysis, Protein Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods Stathmin Two‐dimensional gel electrophoresis
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