T2-low signal intensity in the cortex in multiple system atrophy
To determine the clinical significance of T2-low signal intensity in the cortex of patients presenting parkinsonism, T2-weighted magnetic resonance (MR) images of the cortex of patients with multiple system atrophy (MSA), Parkinson's disease (PD) and progressive supranuclear palsy (PSP), and co...
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| Veröffentlicht in: | Journal of the neurological sciences 2003-07, Vol.211 (1), p.85-88 |
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| container_title | Journal of the neurological sciences |
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| creator | Miwa, Hideto Kajimoto, Yoshinori Nakanishi, Ichiro Morita, Shuhei Komoto, Junko Kihira, Tameko Kondo, Tomoyoshi |
| description | To determine the clinical significance of T2-low signal intensity in the cortex of patients presenting parkinsonism, T2-weighted magnetic resonance (MR) images of the cortex of patients with multiple system atrophy (MSA), Parkinson's disease (PD) and progressive supranuclear palsy (PSP), and compared with those of patients with amyotrophic lateral sclerosis (ALS) and age-matched normal controls. The MR images were gathered and presented randomly to three neurologists who were blind to information on the patients. There was a significant increase in the frequency of T2-low signal intensity in the cortex of patients with ALS and MSA. Particularly in those with MSA, the T2-low signal intensity was observed not only in the motor cortex but also in the frontal association cortex. The cortical T2-low signal intensity in MSA might reflect the spread of degenerative processes in the cortex. |
| doi_str_mv | 10.1016/S0022-510X(03)00061-3 |
| format | Article |
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The MR images were gathered and presented randomly to three neurologists who were blind to information on the patients. There was a significant increase in the frequency of T2-low signal intensity in the cortex of patients with ALS and MSA. Particularly in those with MSA, the T2-low signal intensity was observed not only in the motor cortex but also in the frontal association cortex. The cortical T2-low signal intensity in MSA might reflect the spread of degenerative processes in the cortex.</description><identifier>ISSN: 0022-510X</identifier><identifier>EISSN: 1878-5883</identifier><identifier>DOI: 10.1016/S0022-510X(03)00061-3</identifier><identifier>PMID: 12767503</identifier><identifier>CODEN: JNSCAG</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Aged ; Aged, 80 and over ; Amyotrophic lateral sclerosis ; Amyotrophic Lateral Sclerosis - pathology ; Amyotrophic Lateral Sclerosis - physiopathology ; Biological and medical sciences ; Brain Mapping ; Case-Control Studies ; Cerebral Cortex - pathology ; Cortex ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Double-Blind Method ; Female ; Follow-Up Studies ; Humans ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Middle Aged ; MRI ; Multiple system atrophy ; Multiple System Atrophy - pathology ; Multiple System Atrophy - physiopathology ; Neurology ; Parkinson Disease - pathology ; Parkinson Disease - physiopathology ; Parkinson's disease ; Progressive supranuclear palsy ; Supranuclear Palsy, Progressive - pathology ; Supranuclear Palsy, Progressive - physiopathology</subject><ispartof>Journal of the neurological sciences, 2003-07, Vol.211 (1), p.85-88</ispartof><rights>2003 Elsevier Science B.V.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-bde8779fee6ab9f408e33263cc87dff2392d6d929ceed6dc2233d1b6dae679813</citedby><cites>FETCH-LOGICAL-c391t-bde8779fee6ab9f408e33263cc87dff2392d6d929ceed6dc2233d1b6dae679813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0022-510X(03)00061-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14808433$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12767503$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miwa, Hideto</creatorcontrib><creatorcontrib>Kajimoto, Yoshinori</creatorcontrib><creatorcontrib>Nakanishi, Ichiro</creatorcontrib><creatorcontrib>Morita, Shuhei</creatorcontrib><creatorcontrib>Komoto, Junko</creatorcontrib><creatorcontrib>Kihira, Tameko</creatorcontrib><creatorcontrib>Kondo, Tomoyoshi</creatorcontrib><title>T2-low signal intensity in the cortex in multiple system atrophy</title><title>Journal of the neurological sciences</title><addtitle>J Neurol Sci</addtitle><description>To determine the clinical significance of T2-low signal intensity in the cortex of patients presenting parkinsonism, T2-weighted magnetic resonance (MR) images of the cortex of patients with multiple system atrophy (MSA), Parkinson's disease (PD) and progressive supranuclear palsy (PSP), and compared with those of patients with amyotrophic lateral sclerosis (ALS) and age-matched normal controls. The MR images were gathered and presented randomly to three neurologists who were blind to information on the patients. There was a significant increase in the frequency of T2-low signal intensity in the cortex of patients with ALS and MSA. Particularly in those with MSA, the T2-low signal intensity was observed not only in the motor cortex but also in the frontal association cortex. The cortical T2-low signal intensity in MSA might reflect the spread of degenerative processes in the cortex.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Amyotrophic lateral sclerosis</subject><subject>Amyotrophic Lateral Sclerosis - pathology</subject><subject>Amyotrophic Lateral Sclerosis - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Brain Mapping</subject><subject>Case-Control Studies</subject><subject>Cerebral Cortex - pathology</subject><subject>Cortex</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>MRI</subject><subject>Multiple system atrophy</subject><subject>Multiple System Atrophy - pathology</subject><subject>Multiple System Atrophy - physiopathology</subject><subject>Neurology</subject><subject>Parkinson Disease - pathology</subject><subject>Parkinson Disease - physiopathology</subject><subject>Parkinson's disease</subject><subject>Progressive supranuclear palsy</subject><subject>Supranuclear Palsy, Progressive - pathology</subject><subject>Supranuclear Palsy, Progressive - physiopathology</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMlOwzAQhi0EoqXwCKBcQHAIeGkS-wSoYpMqcaBI3CzHnlCjLMV2gb49SRvRI6f5R_pm0YfQMcGXBJP06gVjSuOE4LdzzC4wximJ2Q4aEp7xOOGc7aLhHzJAB95_dBDnYh8NCM3SLMFsiG5mNC6b78jb91qVka0D1N6GVZuiMIdINy7AT9dVyzLYRQmRX_kAVaSCaxbz1SHaK1Tp4aivI_R6fzebPMbT54enye001kyQEOcGeJaJAiBVuSjGmANjNGVa88wUBWWCmtQIKjRAGzSljBmSp0ZBmglO2AidbfYuXPO5BB9kZb2GslQ1NEsvM0ZFgjFvwWQDatd476CQC2cr5VaSYNmpk2t1svMiMZNrdZK1cyf9gWVegdlO9a5a4LQHlNeqLJyqtfVbbswxH7OOu95w0Or4suCk1xZqDcY60EGaxv7zyi8Tq4tO</recordid><startdate>20030715</startdate><enddate>20030715</enddate><creator>Miwa, Hideto</creator><creator>Kajimoto, Yoshinori</creator><creator>Nakanishi, Ichiro</creator><creator>Morita, Shuhei</creator><creator>Komoto, Junko</creator><creator>Kihira, Tameko</creator><creator>Kondo, Tomoyoshi</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030715</creationdate><title>T2-low signal intensity in the cortex in multiple system atrophy</title><author>Miwa, Hideto ; Kajimoto, Yoshinori ; Nakanishi, Ichiro ; Morita, Shuhei ; Komoto, Junko ; Kihira, Tameko ; Kondo, Tomoyoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-bde8779fee6ab9f408e33263cc87dff2392d6d929ceed6dc2233d1b6dae679813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Amyotrophic lateral sclerosis</topic><topic>Amyotrophic Lateral Sclerosis - pathology</topic><topic>Amyotrophic Lateral Sclerosis - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Brain Mapping</topic><topic>Case-Control Studies</topic><topic>Cerebral Cortex - pathology</topic><topic>Cortex</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>MRI</topic><topic>Multiple system atrophy</topic><topic>Multiple System Atrophy - pathology</topic><topic>Multiple System Atrophy - physiopathology</topic><topic>Neurology</topic><topic>Parkinson Disease - pathology</topic><topic>Parkinson Disease - physiopathology</topic><topic>Parkinson's disease</topic><topic>Progressive supranuclear palsy</topic><topic>Supranuclear Palsy, Progressive - pathology</topic><topic>Supranuclear Palsy, Progressive - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miwa, Hideto</creatorcontrib><creatorcontrib>Kajimoto, Yoshinori</creatorcontrib><creatorcontrib>Nakanishi, Ichiro</creatorcontrib><creatorcontrib>Morita, Shuhei</creatorcontrib><creatorcontrib>Komoto, Junko</creatorcontrib><creatorcontrib>Kihira, Tameko</creatorcontrib><creatorcontrib>Kondo, Tomoyoshi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miwa, Hideto</au><au>Kajimoto, Yoshinori</au><au>Nakanishi, Ichiro</au><au>Morita, Shuhei</au><au>Komoto, Junko</au><au>Kihira, Tameko</au><au>Kondo, Tomoyoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>T2-low signal intensity in the cortex in multiple system atrophy</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>2003-07-15</date><risdate>2003</risdate><volume>211</volume><issue>1</issue><spage>85</spage><epage>88</epage><pages>85-88</pages><issn>0022-510X</issn><eissn>1878-5883</eissn><coden>JNSCAG</coden><abstract>To determine the clinical significance of T2-low signal intensity in the cortex of patients presenting parkinsonism, T2-weighted magnetic resonance (MR) images of the cortex of patients with multiple system atrophy (MSA), Parkinson's disease (PD) and progressive supranuclear palsy (PSP), and compared with those of patients with amyotrophic lateral sclerosis (ALS) and age-matched normal controls. The MR images were gathered and presented randomly to three neurologists who were blind to information on the patients. There was a significant increase in the frequency of T2-low signal intensity in the cortex of patients with ALS and MSA. Particularly in those with MSA, the T2-low signal intensity was observed not only in the motor cortex but also in the frontal association cortex. The cortical T2-low signal intensity in MSA might reflect the spread of degenerative processes in the cortex.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>12767503</pmid><doi>10.1016/S0022-510X(03)00061-3</doi><tpages>4</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - pathology Amyotrophic Lateral Sclerosis - physiopathology Biological and medical sciences Brain Mapping Case-Control Studies Cerebral Cortex - pathology Cortex Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Double-Blind Method Female Follow-Up Studies Humans Magnetic Resonance Imaging Male Medical sciences Middle Aged MRI Multiple system atrophy Multiple System Atrophy - pathology Multiple System Atrophy - physiopathology Neurology Parkinson Disease - pathology Parkinson Disease - physiopathology Parkinson's disease Progressive supranuclear palsy Supranuclear Palsy, Progressive - pathology Supranuclear Palsy, Progressive - physiopathology |
| title | T2-low signal intensity in the cortex in multiple system atrophy |
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