6-hydroxy-3-n-propyl-2,3,4,5-tetrahydro-1H-3-benzazepine and analogs : new centrally acting 5-HT1A receptor agonists

The ring-closed phenylethylamine analogue 6-hydroxy-3-n-propyl-2,3,4,5-tetrahydro-1H-3-benzazepine (1) is a 5-HT1A receptor agonist of moderate potency, according to both in vivo biochemical data and in vitro binding data. The active compounds of this series also induce the 5-HT behavioral syndrome....

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Veröffentlicht in:	Journal of medicinal chemistry 1992-10, Vol.35 (22), p.3984-3990
Hauptverfasser:	WIKSTRÖM, H, ANDERSSON, B, ELEBRING, T, LAGERKVIST, S, HALLNEMO, G, PETTERSSON, I, JOVAL, P.-Å, SVENSSON, K, EKMAN, A, CARLSSON, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzazepines - chemistry Benzazepines - pharmacology Binding, Competitive Biological and medical sciences Brain - drug effects Brain - metabolism Dopamine - biosynthesis Feedback In Vitro Techniques Male Medical sciences Models, Molecular Molecular Conformation Motor Activity - drug effects Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Norepinephrine - biosynthesis Pharmacology. Drug treatments Radioligand Assay Rats Rats, Sprague-Dawley Receptors, Serotonin - drug effects Receptors, Serotonin - metabolism Serotonin - biosynthesis Serotonin Receptor Agonists - chemistry Serotonin Receptor Agonists - pharmacology Serotoninergic system Structure-Activity Relationship Thermodynamics
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