Alloimmunization to platelet antigen HPA-1a (PIA1) is strongly associated with both HLA-DRB30101 and HLA-DQB10201

Antibodies to the platelet HPA-1a antigen can elicit in the newborn a condition known as neonatal alloimmune thrombocytopenic purpura (NAITP). Previous studies based on RFLP analysis showed that 100% of HPA-1a-negative women who produced anti-HPA-1a antibodies (responders) were HLA-DRw52a (DRB3*0101...

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Veröffentlicht in:	Human immunology 1992-06, Vol.34 (2), p.107-114
Hauptverfasser:	L'ABBE, D, TREMBLAY, L, FILION, M, BUSQUE, L, GOLDMAN, M, DECARY, F, CHARTRAND, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Antigens, Human Platelet - genetics Antigens, Human Platelet - immunology Base Sequence Biological and medical sciences Delivery. Postpartum. Lactation Disorders Female Gene Frequency Genes, MHC Class II Genetic Predisposition to Disease Gynecology. Andrology. Obstetrics HLA-DQ Antigens - genetics HLA-DQ beta-Chains HLA-DR Antigens - genetics HLA-DRB3 Chains Humans Immunity, Maternally-Acquired Immunization Incidence Infant, Newborn Isoantibodies - immunology Maternal-Fetal Exchange Medical sciences Molecular Sequence Data Platelet Membrane Glycoproteins - genetics Platelet Membrane Glycoproteins - immunology Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Pregnancy Purpura, Thrombocytopenic - congenital Purpura, Thrombocytopenic - epidemiology Purpura, Thrombocytopenic - immunology
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