giant nuclei is essential in the cell cycle transition from meiosis to mitosis
At the transition from meiosis to cleavage mitoses, Drosophila requires the cell cycle regulators encoded by the genes, giant nuclei (gnu), plutonium (plu) and pan gu (png). Embryos lacking Gnu protein undergo DNA replication and centrosome proliferation without chromosome condensation or mitotic se...
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| Veröffentlicht in: | Development (Cambridge) 2003-07, Vol.130 (13), p.2997-3005 |
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| container_title | Development (Cambridge) |
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| creator | Renault, Andrew D Zhang, Xiao-Hua Alphey, Luke S Frenz, Lisa M Glover, David M Saunders, Robert D C Axton, J Myles |
| description | At the transition from meiosis to cleavage mitoses, Drosophila requires the cell cycle regulators encoded by the genes, giant nuclei (gnu), plutonium (plu) and pan gu (png). Embryos lacking Gnu protein undergo DNA replication and centrosome proliferation without chromosome condensation or mitotic segregation. We have identified the gnu gene encoding a novel phosphoprotein dephosphorylated by Protein phosphatase 1 at egg activation. Gnu is normally expressed in the nurse cells and oocyte of the ovary and is degraded during the embryonic cleavage mitoses. Ovarian death and sterility result from gnu gain of function. gnu function requires the activity of pan gu and plu. |
| doi_str_mv | 10.1242/dev.00501 |
| format | Article |
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Embryos lacking Gnu protein undergo DNA replication and centrosome proliferation without chromosome condensation or mitotic segregation. We have identified the gnu gene encoding a novel phosphoprotein dephosphorylated by Protein phosphatase 1 at egg activation. Gnu is normally expressed in the nurse cells and oocyte of the ovary and is degraded during the embryonic cleavage mitoses. 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Ovarian death and sterility result from gnu gain of function. gnu function requires the activity of pan gu and plu.</description><subject>Actins - metabolism</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Cell Cycle Proteins - chemistry</subject><subject>Cell Cycle Proteins - genetics</subject><subject>Cell Cycle Proteins - metabolism</subject><subject>Cell Nucleus - metabolism</subject><subject>DNA Replication</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Drosophila melanogaster - cytology</subject><subject>Drosophila melanogaster - embryology</subject><subject>Drosophila melanogaster - physiology</subject><subject>Drosophila Proteins - chemistry</subject><subject>Drosophila Proteins - genetics</subject><subject>Drosophila Proteins - metabolism</subject><subject>Epistasis, Genetic</subject><subject>Female</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Infertility</subject><subject>Male</subject><subject>Meiosis - physiology</subject><subject>Mitosis - physiology</subject><subject>Molecular Sequence Data</subject><subject>Oocytes - cytology</subject><subject>Oocytes - physiology</subject><subject>Ovary - cytology</subject><subject>Ovary - physiology</subject><subject>Phenotype</subject><subject>Phosphorylation</subject><subject>Protein Processing, Post-Translational</subject><subject>Protein-Serine-Threonine Kinases - genetics</subject><subject>Protein-Serine-Threonine Kinases - metabolism</subject><subject>Recombinant Fusion Proteins - genetics</subject><subject>Recombinant Fusion Proteins - metabolism</subject><subject>Recombination, Genetic</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><subject>Transgenes</subject><issn>0950-1991</issn><issn>1477-9129</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1LxDAQhoMo7rp68A9IToKHrpkkbZKjLH7Bohc9lzRNNNKma5IK--_tugueZmCe92V4ELoEsgTK6W1rf5aElASO0By4EIUCqo7RnKiSFKAUzNBZSl-EEFYJcYpmQEVZgYQ5evnwOmQcRtNZj33CNiUbstcd9gHnT4uN7TpsttMd56hD8tkPAbs49Li3fkhTJg-493m3nqMTp7tkLw5zgd4f7t9WT8X69fF5dbcuDJWQC2d4BaIRmivGuCxJKxwxlFUt1YYLMIpA1bSCSackqLaSSivRqIY65TglbIGu972bOHyPNuW692n3qQ52GFMtGJVKVnwCb_agiUNK0bp6E32v47YGUu_k1ZO8-k_exF4dSsemt-0_ebDFfgEWWmnF</recordid><startdate>200307</startdate><enddate>200307</enddate><creator>Renault, Andrew D</creator><creator>Zhang, Xiao-Hua</creator><creator>Alphey, Luke S</creator><creator>Frenz, Lisa M</creator><creator>Glover, David M</creator><creator>Saunders, Robert D C</creator><creator>Axton, J Myles</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200307</creationdate><title>giant nuclei is essential in the cell cycle transition from meiosis to mitosis</title><author>Renault, Andrew D ; Zhang, Xiao-Hua ; Alphey, Luke S ; Frenz, Lisa M ; Glover, David M ; Saunders, Robert D C ; Axton, J Myles</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c281t-fc4617b7a49334850d7f0c236d2ac471c9016bd738f9819d689a97b9b2f9f4203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Actins - metabolism</topic><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Cell Cycle Proteins - chemistry</topic><topic>Cell Cycle Proteins - genetics</topic><topic>Cell Cycle Proteins - metabolism</topic><topic>Cell Nucleus - metabolism</topic><topic>DNA Replication</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Drosophila melanogaster - cytology</topic><topic>Drosophila melanogaster - embryology</topic><topic>Drosophila melanogaster - physiology</topic><topic>Drosophila Proteins - chemistry</topic><topic>Drosophila Proteins - genetics</topic><topic>Drosophila Proteins - metabolism</topic><topic>Epistasis, Genetic</topic><topic>Female</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Infertility</topic><topic>Male</topic><topic>Meiosis - physiology</topic><topic>Mitosis - physiology</topic><topic>Molecular Sequence Data</topic><topic>Oocytes - cytology</topic><topic>Oocytes - physiology</topic><topic>Ovary - cytology</topic><topic>Ovary - physiology</topic><topic>Phenotype</topic><topic>Phosphorylation</topic><topic>Protein Processing, Post-Translational</topic><topic>Protein-Serine-Threonine Kinases - genetics</topic><topic>Protein-Serine-Threonine Kinases - metabolism</topic><topic>Recombinant Fusion Proteins - genetics</topic><topic>Recombinant Fusion Proteins - metabolism</topic><topic>Recombination, Genetic</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><topic>Transgenes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Renault, Andrew D</creatorcontrib><creatorcontrib>Zhang, Xiao-Hua</creatorcontrib><creatorcontrib>Alphey, Luke S</creatorcontrib><creatorcontrib>Frenz, Lisa M</creatorcontrib><creatorcontrib>Glover, David M</creatorcontrib><creatorcontrib>Saunders, Robert D C</creatorcontrib><creatorcontrib>Axton, J Myles</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Development (Cambridge)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Renault, Andrew D</au><au>Zhang, Xiao-Hua</au><au>Alphey, Luke S</au><au>Frenz, Lisa M</au><au>Glover, David M</au><au>Saunders, Robert D C</au><au>Axton, J Myles</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>giant nuclei is essential in the cell cycle transition from meiosis to mitosis</atitle><jtitle>Development (Cambridge)</jtitle><addtitle>Development</addtitle><date>2003-07</date><risdate>2003</risdate><volume>130</volume><issue>13</issue><spage>2997</spage><epage>3005</epage><pages>2997-3005</pages><issn>0950-1991</issn><eissn>1477-9129</eissn><abstract>At the transition from meiosis to cleavage mitoses, Drosophila requires the cell cycle regulators encoded by the genes, giant nuclei (gnu), plutonium (plu) and pan gu (png). Embryos lacking Gnu protein undergo DNA replication and centrosome proliferation without chromosome condensation or mitotic segregation. We have identified the gnu gene encoding a novel phosphoprotein dephosphorylated by Protein phosphatase 1 at egg activation. Gnu is normally expressed in the nurse cells and oocyte of the ovary and is degraded during the embryonic cleavage mitoses. Ovarian death and sterility result from gnu gain of function. gnu function requires the activity of pan gu and plu.</abstract><cop>England</cop><pmid>12756181</pmid><doi>10.1242/dev.00501</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0950-1991 |
| ispartof | Development (Cambridge), 2003-07, Vol.130 (13), p.2997-3005 |
| issn | 0950-1991 1477-9129 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; Company of Biologists |
| subjects | Actins - metabolism Amino Acid Sequence Animals Base Sequence Cell Cycle Proteins - chemistry Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Nucleus - metabolism DNA Replication DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Drosophila melanogaster - cytology Drosophila melanogaster - embryology Drosophila melanogaster - physiology Drosophila Proteins - chemistry Drosophila Proteins - genetics Drosophila Proteins - metabolism Epistasis, Genetic Female Gene Expression Regulation, Developmental Infertility Male Meiosis - physiology Mitosis - physiology Molecular Sequence Data Oocytes - cytology Oocytes - physiology Ovary - cytology Ovary - physiology Phenotype Phosphorylation Protein Processing, Post-Translational Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Recombination, Genetic Transcription Factors - genetics Transcription Factors - metabolism Transgenes |
| title | giant nuclei is essential in the cell cycle transition from meiosis to mitosis |
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