A nonintrinsic regional basis for increased infrarenal aortic MMP-9 expression and activity

Objective: This investigation was undertaken to determine whether intrinsic or regional factors at different anatomic sites of the aorta affect expression and activity of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). Methods: Aortas from Sprague-Dawley rats (n...

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Veröffentlicht in:	Journal of vascular surgery 2003-05, Vol.37 (5), p.1059-1066
Hauptverfasser:	Ailawadi, Gorav, Knipp, Brian S., Lu, Guanyi, Roelofs, Karen J., Ford, John W., Hannawa, Kevin K., Bishop, Keith, Thanaporn, Porama, Henke, Peter K., Stanley, James C., Upchurch, Gilbert R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - drug effects Actins - metabolism Animals Aorta, Abdominal - enzymology Aorta, Abdominal - pathology Aorta, Abdominal - transplantation Aorta, Thoracic - metabolism Aorta, Thoracic - pathology Aorta, Thoracic - transplantation Aortic Aneurysm, Abdominal - metabolism Aortic Aneurysm, Abdominal - surgery Biological and medical sciences Blood and lymphatic vessels Blood Pressure - physiology Cardiology. Vascular system Chelating Agents - pharmacology Disease Models, Animal Diseases of the aorta Edetic Acid - pharmacology Gelatin - drug effects Gelatin - metabolism Gelatinases - drug effects Gelatinases - metabolism Heart Rate - physiology Leupeptins - pharmacology Male Matrix Metalloproteinase 2 - drug effects Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - biosynthesis Matrix Metalloproteinase 9 - drug effects Matrix Metalloproteinase 9 - metabolism Medical sciences Models, Cardiovascular Phenylmethylsulfonyl Fluoride - pharmacology Protease Inhibitors - pharmacology Rats Rats, Sprague-Dawley RNA, Messenger - drug effects RNA, Messenger - metabolism Tissue Inhibitor of Metalloproteinase-1 - drug effects Tissue Inhibitor of Metalloproteinase-1 - metabolism
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