Host-pathogen interactions during apoptosis
Host pathogen interaction results in a variety of responses, which include phagocytosis of the pathogen, release of cytokines, secretion of toxins, as well as production of reactive oxygen species (ROS). Recent studies have shown that many pathogens exert control on the processes that regulate apopt...
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| Veröffentlicht in: | Journal of biosciences 2003-04, Vol.28 (3), p.349-358 |
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| container_title | Journal of biosciences |
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| creator | Hasnain, Seyed E Begum, Rasheeda Ramaiah, K V A Sahdev, Sudhir Shajil, E M Taneja, Tarvinder K Mohan, Manjari Athar, M Sah, Nand K Krishnaveni, M |
| description | Host pathogen interaction results in a variety of responses, which include phagocytosis of the pathogen, release of cytokines, secretion of toxins, as well as production of reactive oxygen species (ROS). Recent studies have shown that many pathogens exert control on the processes that regulate apoptosis in the host. The induction of apoptosis upon infection results from a complex interaction of parasite proteins with cellular host proteins. Abrogation of host cell apoptosis is often beneficial for the pathogen and results in a successful host invasion. However, in some cases, it has been shown that induction of apoptosis in the infected cells significantly imparts protection to the host from the pathogen. There is a strong correlation between apoptosis and the host protein translation machinery: the pathogen makes all possible efforts to modify this process so as to inhibit cell suicide and ensure that it can survive and, in some cases, establish latent infection. This review discusses the significance of various pathways/steps during virus-mediated modulation of host cell apoptosis. |
| doi_str_mv | 10.1007/BF02970153 |
| format | Article |
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Recent studies have shown that many pathogens exert control on the processes that regulate apoptosis in the host. The induction of apoptosis upon infection results from a complex interaction of parasite proteins with cellular host proteins. Abrogation of host cell apoptosis is often beneficial for the pathogen and results in a successful host invasion. However, in some cases, it has been shown that induction of apoptosis in the infected cells significantly imparts protection to the host from the pathogen. There is a strong correlation between apoptosis and the host protein translation machinery: the pathogen makes all possible efforts to modify this process so as to inhibit cell suicide and ensure that it can survive and, in some cases, establish latent infection. This review discusses the significance of various pathways/steps during virus-mediated modulation of host cell apoptosis.</description><identifier>ISSN: 0250-5991</identifier><identifier>EISSN: 0973-7138</identifier><identifier>DOI: 10.1007/BF02970153</identifier><identifier>PMID: 12734412</identifier><language>eng</language><publisher>India: Springer Nature B.V</publisher><subject>Animals ; Apoptosis ; Apoptosis - physiology ; Baculoviridae - physiology ; Cells ; Cytokines ; Host-pathogen interactions ; Latent infection ; Oxidative Stress ; Parasites ; Pathogens ; Phagocytosis ; Protein Biosynthesis ; Proteins ; Reactive oxygen species ; Reactive Oxygen Species - metabolism ; Secretion ; Signal Transduction - physiology ; Suicide ; Survival ; Toxins ; Virus Diseases - metabolism ; Virus Diseases - pathology ; Virus Diseases - virology ; Virus Physiological Phenomena</subject><ispartof>Journal of biosciences, 2003-04, Vol.28 (3), p.349-358</ispartof><rights>Indian Academy of Sciences 2003</rights><rights>Indian Academy of Sciences 2003.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c340t-afcabac113cf2a0ac2931d93fd1d6b7648e61800f6002c0c9599ae5689860b213</citedby><cites>FETCH-LOGICAL-c340t-afcabac113cf2a0ac2931d93fd1d6b7648e61800f6002c0c9599ae5689860b213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12734412$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hasnain, Seyed E</creatorcontrib><creatorcontrib>Begum, Rasheeda</creatorcontrib><creatorcontrib>Ramaiah, K V A</creatorcontrib><creatorcontrib>Sahdev, Sudhir</creatorcontrib><creatorcontrib>Shajil, E M</creatorcontrib><creatorcontrib>Taneja, Tarvinder K</creatorcontrib><creatorcontrib>Mohan, Manjari</creatorcontrib><creatorcontrib>Athar, M</creatorcontrib><creatorcontrib>Sah, Nand K</creatorcontrib><creatorcontrib>Krishnaveni, M</creatorcontrib><title>Host-pathogen interactions during apoptosis</title><title>Journal of biosciences</title><addtitle>J Biosci</addtitle><description>Host pathogen interaction results in a variety of responses, which include phagocytosis of the pathogen, release of cytokines, secretion of toxins, as well as production of reactive oxygen species (ROS). Recent studies have shown that many pathogens exert control on the processes that regulate apoptosis in the host. The induction of apoptosis upon infection results from a complex interaction of parasite proteins with cellular host proteins. Abrogation of host cell apoptosis is often beneficial for the pathogen and results in a successful host invasion. However, in some cases, it has been shown that induction of apoptosis in the infected cells significantly imparts protection to the host from the pathogen. There is a strong correlation between apoptosis and the host protein translation machinery: the pathogen makes all possible efforts to modify this process so as to inhibit cell suicide and ensure that it can survive and, in some cases, establish latent infection. This review discusses the significance of various pathways/steps during virus-mediated modulation of host cell apoptosis.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Apoptosis - physiology</subject><subject>Baculoviridae - physiology</subject><subject>Cells</subject><subject>Cytokines</subject><subject>Host-pathogen interactions</subject><subject>Latent infection</subject><subject>Oxidative Stress</subject><subject>Parasites</subject><subject>Pathogens</subject><subject>Phagocytosis</subject><subject>Protein Biosynthesis</subject><subject>Proteins</subject><subject>Reactive oxygen species</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Secretion</subject><subject>Signal Transduction - physiology</subject><subject>Suicide</subject><subject>Survival</subject><subject>Toxins</subject><subject>Virus Diseases - metabolism</subject><subject>Virus Diseases - pathology</subject><subject>Virus Diseases - virology</subject><subject>Virus Physiological Phenomena</subject><issn>0250-5991</issn><issn>0973-7138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp10E9Lw0AQBfBFFFurFz-AFAUPSnRmJ9k_Ry3WCgUveg7bzaamtNm4mxz89qa0UBA8zRx-PB6PsUuEBwSQj89T4FoCZnTEhqAlJRJJHfc_zyDJtMYBO4txBYA6JThlA-SS0hT5kN3PfGyTxrRffunqcVW3LhjbVr6O46ILVb0cm8Y3rY9VPGcnpVlHd7G_I_Y5ffmYzJL5--vb5GmeWEqhTUxpzcJYRLIlN2As14SFprLAQiykSJUTqABKAcAtWN03NC4TSisBC440Yre73Cb4787FNt9U0br12tTOdzGXxJWQtIU3f-DKd6Huu-Vc6FRBhmKrrv9VJDhXlMke3e2QDT7G4Mq8CdXGhJ8cId-unB9W7vHVPrFbbFxxoPtZ6RfHe3Qm</recordid><startdate>20030401</startdate><enddate>20030401</enddate><creator>Hasnain, Seyed E</creator><creator>Begum, Rasheeda</creator><creator>Ramaiah, K V A</creator><creator>Sahdev, Sudhir</creator><creator>Shajil, E M</creator><creator>Taneja, Tarvinder K</creator><creator>Mohan, Manjari</creator><creator>Athar, M</creator><creator>Sah, Nand K</creator><creator>Krishnaveni, M</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H99</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.F</scope><scope>L.G</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20030401</creationdate><title>Host-pathogen interactions during apoptosis</title><author>Hasnain, Seyed E ; Begum, Rasheeda ; Ramaiah, K V A ; Sahdev, Sudhir ; Shajil, E M ; Taneja, Tarvinder K ; Mohan, Manjari ; Athar, M ; Sah, Nand K ; Krishnaveni, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c340t-afcabac113cf2a0ac2931d93fd1d6b7648e61800f6002c0c9599ae5689860b213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Apoptosis - 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Recent studies have shown that many pathogens exert control on the processes that regulate apoptosis in the host. The induction of apoptosis upon infection results from a complex interaction of parasite proteins with cellular host proteins. Abrogation of host cell apoptosis is often beneficial for the pathogen and results in a successful host invasion. However, in some cases, it has been shown that induction of apoptosis in the infected cells significantly imparts protection to the host from the pathogen. There is a strong correlation between apoptosis and the host protein translation machinery: the pathogen makes all possible efforts to modify this process so as to inhibit cell suicide and ensure that it can survive and, in some cases, establish latent infection. This review discusses the significance of various pathways/steps during virus-mediated modulation of host cell apoptosis.</abstract><cop>India</cop><pub>Springer Nature B.V</pub><pmid>12734412</pmid><doi>10.1007/BF02970153</doi><tpages>10</tpages></addata></record> |
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| ispartof | Journal of biosciences, 2003-04, Vol.28 (3), p.349-358 |
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| source | MEDLINE; Indian Academy of Sciences; Springer Nature - Complete Springer Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Apoptosis Apoptosis - physiology Baculoviridae - physiology Cells Cytokines Host-pathogen interactions Latent infection Oxidative Stress Parasites Pathogens Phagocytosis Protein Biosynthesis Proteins Reactive oxygen species Reactive Oxygen Species - metabolism Secretion Signal Transduction - physiology Suicide Survival Toxins Virus Diseases - metabolism Virus Diseases - pathology Virus Diseases - virology Virus Physiological Phenomena |
| title | Host-pathogen interactions during apoptosis |
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