Retinal microvascular abnormalities and 10-year cardiovascular mortality: A population-based case-control study
Retinal microvascular abnormalities reflect persistent arteriolar damage from hypertension and independently predict stroke. We examined their associations with long-term cardiovascular mortality. Population-based, nested, case-control study. Cases were Beaver Dam Eye Study participants (age range,...
Gespeichert in:
| Veröffentlicht in: | Ophthalmology (Rochester, Minn.) Minn.), 2003-05, Vol.110 (5), p.933-940 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 940 |
|---|---|
| container_issue | 5 |
| container_start_page | 933 |
| container_title | Ophthalmology (Rochester, Minn.) |
| container_volume | 110 |
| creator | Wong, Tien Yin Klein, Ronald Nieto, F.Javier Klein, Barbara E.K Sharrett, A.Richey Meuer, Stacy M Hubbard, Larry D Tielsch, James M |
| description | Retinal microvascular abnormalities reflect persistent arteriolar damage from hypertension and independently predict stroke. We examined their associations with long-term cardiovascular mortality.
Population-based, nested, case-control study.
Cases were Beaver Dam Eye Study participants (age range, 43–84 years) who died of coronary heart disease or stroke between the baseline examination in 1988 to 1990 and 1999 (n = 413). Nearly 3 controls per case were selected from the baseline cohort, frequency-matched on 5-year age intervals and gender (n = 1198).
Retinal photographs of cases and controls at baseline were evaluated for retinopathy, focal arteriolar narrowing, and arteriovenous nicking by graders masked to case-control status using standardized protocols. To obtain an estimate of generalized arteriolar narrowing, photographs were digitized and diameters of individual retinal vessels were measured and summarized by a computer program.
Ten-year cardiovascular mortality.
After controlling for systolic blood pressure, diabetes, glycosylated hemoglobin levels, and other risk factors, retinopathy was associated with increased cardiovascular mortality, with odds ratios of 1.8 (95% confidence interval [CI], 1.2, 2.7). For other retinal abnormalities, associations with cardiovascular mortality were present only in younger people, with odds ratios of 2.7 (95% CI, 1.0, 7.4) for focal arteriolar narrowing, 1.8 (95% CI, 0.8, 4.5) for arteriovenous nicking, and 1.9 (95% CI, 1.2, 2.9) for generalized arteriolar narrowing in persons 43 to 74 years of age but odds ratios of 1.1, 0.4, and 1.0 for the corresponding retinal abnormalities in persons 75 years and older.
Retinopathy is independently associated with cardiovascular mortality. Associations for other retinal abnormalities were only observed in middle-aged persons. These data support recent studies that suggest retinal microvascular abnormalities provide independent information regarding cardiovascular risk. |
| doi_str_mv | 10.1016/S0161-6420(03)00084-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_73285877</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0161642003000848</els_id><sourcerecordid>73285877</sourcerecordid><originalsourceid>FETCH-LOGICAL-e293t-22d2271f3969dd3811faa903020696712744598b72d337fe339959349ea050ea3</originalsourceid><addsrcrecordid>eNpF0d9LHDEQB_AgLXrV_gmWfam0D6mTH7vZ9KWIaFsQBNs-h1wyC5HdzZlkhfvvzelVXzKQ-TBk8iXklME3Bqw7_1MPRjvJ4QuIrwDQS9ofkBVrpaZSMfGOrF7JEfmQ831FXSfkITliXLUAWqxIvMMSZjs2U3ApPtrsltGmxq7nmCY7hhIwN3b2DQO6xdpxNvnwBqeYyo5tvzcXzSZu6mUJcaZrm9FXnJG6OJcUxyaXxW9PyPvBjhk_7usx-Xd99ffyF725_fn78uKGIteiUM4954oNQnfae9EzNlirQQCHTneqvl_KVvdrxb0QakAhtG61kBottIBWHJOzl7mbFB8WzMVMITscRztjXLJRgvdtr1SFn_ZwWU_ozSaFyaat-f9FFXzeg7qzHYdkZxfym5NKt9Du3I8Xh3Wtx4DJZBdwduhDQleMj8EwMLvwzHN4ZpeMAWGewzO9eAIrg4pm</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>73285877</pqid></control><display><type>article</type><title>Retinal microvascular abnormalities and 10-year cardiovascular mortality: A population-based case-control study</title><source>MEDLINE</source><source>ScienceDirect Freedom Collection (Elsevier)</source><creator>Wong, Tien Yin ; Klein, Ronald ; Nieto, F.Javier ; Klein, Barbara E.K ; Sharrett, A.Richey ; Meuer, Stacy M ; Hubbard, Larry D ; Tielsch, James M</creator><creatorcontrib>Wong, Tien Yin ; Klein, Ronald ; Nieto, F.Javier ; Klein, Barbara E.K ; Sharrett, A.Richey ; Meuer, Stacy M ; Hubbard, Larry D ; Tielsch, James M</creatorcontrib><description>Retinal microvascular abnormalities reflect persistent arteriolar damage from hypertension and independently predict stroke. We examined their associations with long-term cardiovascular mortality.
Population-based, nested, case-control study.
Cases were Beaver Dam Eye Study participants (age range, 43–84 years) who died of coronary heart disease or stroke between the baseline examination in 1988 to 1990 and 1999 (n = 413). Nearly 3 controls per case were selected from the baseline cohort, frequency-matched on 5-year age intervals and gender (n = 1198).
Retinal photographs of cases and controls at baseline were evaluated for retinopathy, focal arteriolar narrowing, and arteriovenous nicking by graders masked to case-control status using standardized protocols. To obtain an estimate of generalized arteriolar narrowing, photographs were digitized and diameters of individual retinal vessels were measured and summarized by a computer program.
Ten-year cardiovascular mortality.
After controlling for systolic blood pressure, diabetes, glycosylated hemoglobin levels, and other risk factors, retinopathy was associated with increased cardiovascular mortality, with odds ratios of 1.8 (95% confidence interval [CI], 1.2, 2.7). For other retinal abnormalities, associations with cardiovascular mortality were present only in younger people, with odds ratios of 2.7 (95% CI, 1.0, 7.4) for focal arteriolar narrowing, 1.8 (95% CI, 0.8, 4.5) for arteriovenous nicking, and 1.9 (95% CI, 1.2, 2.9) for generalized arteriolar narrowing in persons 43 to 74 years of age but odds ratios of 1.1, 0.4, and 1.0 for the corresponding retinal abnormalities in persons 75 years and older.
Retinopathy is independently associated with cardiovascular mortality. Associations for other retinal abnormalities were only observed in middle-aged persons. These data support recent studies that suggest retinal microvascular abnormalities provide independent information regarding cardiovascular risk.</description><identifier>ISSN: 0161-6420</identifier><identifier>EISSN: 1549-4713</identifier><identifier>DOI: 10.1016/S0161-6420(03)00084-8</identifier><identifier>PMID: 12750093</identifier><identifier>CODEN: OPHTDG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure ; Capillaries ; Cardiology. Vascular system ; Cardiovascular Diseases - mortality ; Case-Control Studies ; Diabetes Complications ; Experimental diseases ; Female ; Glycated Hemoglobin A - analysis ; Humans ; Male ; Medical sciences ; Middle Aged ; Odds Ratio ; Photography ; Retinal Diseases - classification ; Retinal Diseases - epidemiology ; Retinal Vessels - pathology ; Risk Factors ; Wisconsin - epidemiology</subject><ispartof>Ophthalmology (Rochester, Minn.), 2003-05, Vol.110 (5), p.933-940</ispartof><rights>2003 American Academy of Ophthalmology</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0161-6420(03)00084-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14795053$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12750093$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wong, Tien Yin</creatorcontrib><creatorcontrib>Klein, Ronald</creatorcontrib><creatorcontrib>Nieto, F.Javier</creatorcontrib><creatorcontrib>Klein, Barbara E.K</creatorcontrib><creatorcontrib>Sharrett, A.Richey</creatorcontrib><creatorcontrib>Meuer, Stacy M</creatorcontrib><creatorcontrib>Hubbard, Larry D</creatorcontrib><creatorcontrib>Tielsch, James M</creatorcontrib><title>Retinal microvascular abnormalities and 10-year cardiovascular mortality: A population-based case-control study</title><title>Ophthalmology (Rochester, Minn.)</title><addtitle>Ophthalmology</addtitle><description>Retinal microvascular abnormalities reflect persistent arteriolar damage from hypertension and independently predict stroke. We examined their associations with long-term cardiovascular mortality.
Population-based, nested, case-control study.
Cases were Beaver Dam Eye Study participants (age range, 43–84 years) who died of coronary heart disease or stroke between the baseline examination in 1988 to 1990 and 1999 (n = 413). Nearly 3 controls per case were selected from the baseline cohort, frequency-matched on 5-year age intervals and gender (n = 1198).
Retinal photographs of cases and controls at baseline were evaluated for retinopathy, focal arteriolar narrowing, and arteriovenous nicking by graders masked to case-control status using standardized protocols. To obtain an estimate of generalized arteriolar narrowing, photographs were digitized and diameters of individual retinal vessels were measured and summarized by a computer program.
Ten-year cardiovascular mortality.
After controlling for systolic blood pressure, diabetes, glycosylated hemoglobin levels, and other risk factors, retinopathy was associated with increased cardiovascular mortality, with odds ratios of 1.8 (95% confidence interval [CI], 1.2, 2.7). For other retinal abnormalities, associations with cardiovascular mortality were present only in younger people, with odds ratios of 2.7 (95% CI, 1.0, 7.4) for focal arteriolar narrowing, 1.8 (95% CI, 0.8, 4.5) for arteriovenous nicking, and 1.9 (95% CI, 1.2, 2.9) for generalized arteriolar narrowing in persons 43 to 74 years of age but odds ratios of 1.1, 0.4, and 1.0 for the corresponding retinal abnormalities in persons 75 years and older.
Retinopathy is independently associated with cardiovascular mortality. Associations for other retinal abnormalities were only observed in middle-aged persons. These data support recent studies that suggest retinal microvascular abnormalities provide independent information regarding cardiovascular risk.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure</subject><subject>Capillaries</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular Diseases - mortality</subject><subject>Case-Control Studies</subject><subject>Diabetes Complications</subject><subject>Experimental diseases</subject><subject>Female</subject><subject>Glycated Hemoglobin A - analysis</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Photography</subject><subject>Retinal Diseases - classification</subject><subject>Retinal Diseases - epidemiology</subject><subject>Retinal Vessels - pathology</subject><subject>Risk Factors</subject><subject>Wisconsin - epidemiology</subject><issn>0161-6420</issn><issn>1549-4713</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0d9LHDEQB_AgLXrV_gmWfam0D6mTH7vZ9KWIaFsQBNs-h1wyC5HdzZlkhfvvzelVXzKQ-TBk8iXklME3Bqw7_1MPRjvJ4QuIrwDQS9ofkBVrpaZSMfGOrF7JEfmQ831FXSfkITliXLUAWqxIvMMSZjs2U3ApPtrsltGmxq7nmCY7hhIwN3b2DQO6xdpxNvnwBqeYyo5tvzcXzSZu6mUJcaZrm9FXnJG6OJcUxyaXxW9PyPvBjhk_7usx-Xd99ffyF725_fn78uKGIteiUM4954oNQnfae9EzNlirQQCHTneqvl_KVvdrxb0QakAhtG61kBottIBWHJOzl7mbFB8WzMVMITscRztjXLJRgvdtr1SFn_ZwWU_ozSaFyaat-f9FFXzeg7qzHYdkZxfym5NKt9Du3I8Xh3Wtx4DJZBdwduhDQleMj8EwMLvwzHN4ZpeMAWGewzO9eAIrg4pm</recordid><startdate>20030501</startdate><enddate>20030501</enddate><creator>Wong, Tien Yin</creator><creator>Klein, Ronald</creator><creator>Nieto, F.Javier</creator><creator>Klein, Barbara E.K</creator><creator>Sharrett, A.Richey</creator><creator>Meuer, Stacy M</creator><creator>Hubbard, Larry D</creator><creator>Tielsch, James M</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20030501</creationdate><title>Retinal microvascular abnormalities and 10-year cardiovascular mortality: A population-based case-control study</title><author>Wong, Tien Yin ; Klein, Ronald ; Nieto, F.Javier ; Klein, Barbara E.K ; Sharrett, A.Richey ; Meuer, Stacy M ; Hubbard, Larry D ; Tielsch, James M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e293t-22d2271f3969dd3811faa903020696712744598b72d337fe339959349ea050ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Pressure</topic><topic>Capillaries</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular Diseases - mortality</topic><topic>Case-Control Studies</topic><topic>Diabetes Complications</topic><topic>Experimental diseases</topic><topic>Female</topic><topic>Glycated Hemoglobin A - analysis</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>Photography</topic><topic>Retinal Diseases - classification</topic><topic>Retinal Diseases - epidemiology</topic><topic>Retinal Vessels - pathology</topic><topic>Risk Factors</topic><topic>Wisconsin - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wong, Tien Yin</creatorcontrib><creatorcontrib>Klein, Ronald</creatorcontrib><creatorcontrib>Nieto, F.Javier</creatorcontrib><creatorcontrib>Klein, Barbara E.K</creatorcontrib><creatorcontrib>Sharrett, A.Richey</creatorcontrib><creatorcontrib>Meuer, Stacy M</creatorcontrib><creatorcontrib>Hubbard, Larry D</creatorcontrib><creatorcontrib>Tielsch, James M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Ophthalmology (Rochester, Minn.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wong, Tien Yin</au><au>Klein, Ronald</au><au>Nieto, F.Javier</au><au>Klein, Barbara E.K</au><au>Sharrett, A.Richey</au><au>Meuer, Stacy M</au><au>Hubbard, Larry D</au><au>Tielsch, James M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retinal microvascular abnormalities and 10-year cardiovascular mortality: A population-based case-control study</atitle><jtitle>Ophthalmology (Rochester, Minn.)</jtitle><addtitle>Ophthalmology</addtitle><date>2003-05-01</date><risdate>2003</risdate><volume>110</volume><issue>5</issue><spage>933</spage><epage>940</epage><pages>933-940</pages><issn>0161-6420</issn><eissn>1549-4713</eissn><coden>OPHTDG</coden><abstract>Retinal microvascular abnormalities reflect persistent arteriolar damage from hypertension and independently predict stroke. We examined their associations with long-term cardiovascular mortality.
Population-based, nested, case-control study.
Cases were Beaver Dam Eye Study participants (age range, 43–84 years) who died of coronary heart disease or stroke between the baseline examination in 1988 to 1990 and 1999 (n = 413). Nearly 3 controls per case were selected from the baseline cohort, frequency-matched on 5-year age intervals and gender (n = 1198).
Retinal photographs of cases and controls at baseline were evaluated for retinopathy, focal arteriolar narrowing, and arteriovenous nicking by graders masked to case-control status using standardized protocols. To obtain an estimate of generalized arteriolar narrowing, photographs were digitized and diameters of individual retinal vessels were measured and summarized by a computer program.
Ten-year cardiovascular mortality.
After controlling for systolic blood pressure, diabetes, glycosylated hemoglobin levels, and other risk factors, retinopathy was associated with increased cardiovascular mortality, with odds ratios of 1.8 (95% confidence interval [CI], 1.2, 2.7). For other retinal abnormalities, associations with cardiovascular mortality were present only in younger people, with odds ratios of 2.7 (95% CI, 1.0, 7.4) for focal arteriolar narrowing, 1.8 (95% CI, 0.8, 4.5) for arteriovenous nicking, and 1.9 (95% CI, 1.2, 2.9) for generalized arteriolar narrowing in persons 43 to 74 years of age but odds ratios of 1.1, 0.4, and 1.0 for the corresponding retinal abnormalities in persons 75 years and older.
Retinopathy is independently associated with cardiovascular mortality. Associations for other retinal abnormalities were only observed in middle-aged persons. These data support recent studies that suggest retinal microvascular abnormalities provide independent information regarding cardiovascular risk.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>12750093</pmid><doi>10.1016/S0161-6420(03)00084-8</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0161-6420 |
| ispartof | Ophthalmology (Rochester, Minn.), 2003-05, Vol.110 (5), p.933-940 |
| issn | 0161-6420 1549-4713 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73285877 |
| source | MEDLINE; ScienceDirect Freedom Collection (Elsevier) |
| subjects | Adult Aged Aged, 80 and over Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure Capillaries Cardiology. Vascular system Cardiovascular Diseases - mortality Case-Control Studies Diabetes Complications Experimental diseases Female Glycated Hemoglobin A - analysis Humans Male Medical sciences Middle Aged Odds Ratio Photography Retinal Diseases - classification Retinal Diseases - epidemiology Retinal Vessels - pathology Risk Factors Wisconsin - epidemiology |
| title | Retinal microvascular abnormalities and 10-year cardiovascular mortality: A population-based case-control study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T20%3A06%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Retinal%20microvascular%20abnormalities%20and%2010-year%20cardiovascular%20mortality:%20A%20population-based%20case-control%20study&rft.jtitle=Ophthalmology%20(Rochester,%20Minn.)&rft.au=Wong,%20Tien%20Yin&rft.date=2003-05-01&rft.volume=110&rft.issue=5&rft.spage=933&rft.epage=940&rft.pages=933-940&rft.issn=0161-6420&rft.eissn=1549-4713&rft.coden=OPHTDG&rft_id=info:doi/10.1016/S0161-6420(03)00084-8&rft_dat=%3Cproquest_pubme%3E73285877%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=73285877&rft_id=info:pmid/12750093&rft_els_id=S0161642003000848&rfr_iscdi=true |