Recurrence of Microbial Keratitis Concomitant with Antiinflammatory Treatment in an Animal Model
Recurrence of Pseudomonas keratitis during treatment with corticosteroids has been reported previously in humans. Rabbits with keratitis due to Pseudomonas aeruginosa or Streptococcus pneumoniae were treated with antibiotics and either vehicle, methylprednisolone acetate, flurbiprofen, or nordihydro...
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| Veröffentlicht in: | Cornea 1992-09, Vol.11 (5), p.404-408 |
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| creator | Gritz, David C Kwitko, Sergio Trousdale, Melvin D Gonzalez, Victor H McDonnell, Peter J |
| description | Recurrence of Pseudomonas keratitis during treatment with corticosteroids has been reported previously in humans. Rabbits with keratitis due to Pseudomonas aeruginosa or Streptococcus pneumoniae were treated with antibiotics and either vehicle, methylprednisolone acetate, flurbiprofen, or nordihydroguaiaretic acid (NDGA). Cultures performed after 7 days were negative, and antibiotics were discontinued. Two weeks later, Pseudomonas keratitis recurred in 6 of 7 (85.7%) steroid-treated rabbits, 1 of 8 (12.5%) flurbiprofen-treated rabbits, 1 of 8 (12.5%) NDGA-treated rabbits, and none of 8 vehicletreated rabbits. None of the 31 rabbits infected with Streptococcus pneumoniae experienced recurrence. These data confirm the clinical observation that Pseudomonas keratitis may recur if antibiotic therapy is discontinued and corticosteroids are administered; the risk of recurrence appears to be much less with nonsteroidal antiinflammatory agents. |
| doi_str_mv | 10.1097/00003226-199209000-00008 |
| format | Article |
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Rabbits with keratitis due to Pseudomonas aeruginosa or Streptococcus pneumoniae were treated with antibiotics and either vehicle, methylprednisolone acetate, flurbiprofen, or nordihydroguaiaretic acid (NDGA). Cultures performed after 7 days were negative, and antibiotics were discontinued. Two weeks later, Pseudomonas keratitis recurred in 6 of 7 (85.7%) steroid-treated rabbits, 1 of 8 (12.5%) flurbiprofen-treated rabbits, 1 of 8 (12.5%) NDGA-treated rabbits, and none of 8 vehicletreated rabbits. None of the 31 rabbits infected with Streptococcus pneumoniae experienced recurrence. These data confirm the clinical observation that Pseudomonas keratitis may recur if antibiotic therapy is discontinued and corticosteroids are administered; the risk of recurrence appears to be much less with nonsteroidal antiinflammatory agents.</description><identifier>ISSN: 0277-3740</identifier><identifier>EISSN: 1536-4798</identifier><identifier>DOI: 10.1097/00003226-199209000-00008</identifier><identifier>PMID: 1424668</identifier><language>eng</language><publisher>United States: Lippincott-Raven Publishers</publisher><subject>Animals ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; Cornea - microbiology ; Disease Models, Animal ; Eye Infections, Bacterial - drug therapy ; Keratitis - drug therapy ; Keratitis - microbiology ; Methylprednisolone - therapeutic use ; Pneumococcal Infections - drug therapy ; Pseudomonas aeruginosa - growth & development ; Pseudomonas Infections - drug therapy ; Rabbits ; Random Allocation ; Recurrence ; Streptococcus pneumoniae - growth & development ; Tobramycin - therapeutic use</subject><ispartof>Cornea, 1992-09, Vol.11 (5), p.404-408</ispartof><rights>Lippincott-Raven Publishers.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3558-36ce405e23181d6d29dd8a055a2f63d8e5a8a12d16395b8cc5734309d37aedea3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1424668$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gritz, David C</creatorcontrib><creatorcontrib>Kwitko, Sergio</creatorcontrib><creatorcontrib>Trousdale, Melvin D</creatorcontrib><creatorcontrib>Gonzalez, Victor H</creatorcontrib><creatorcontrib>McDonnell, Peter J</creatorcontrib><title>Recurrence of Microbial Keratitis Concomitant with Antiinflammatory Treatment in an Animal Model</title><title>Cornea</title><addtitle>Cornea</addtitle><description>Recurrence of Pseudomonas keratitis during treatment with corticosteroids has been reported previously in humans. Rabbits with keratitis due to Pseudomonas aeruginosa or Streptococcus pneumoniae were treated with antibiotics and either vehicle, methylprednisolone acetate, flurbiprofen, or nordihydroguaiaretic acid (NDGA). Cultures performed after 7 days were negative, and antibiotics were discontinued. Two weeks later, Pseudomonas keratitis recurred in 6 of 7 (85.7%) steroid-treated rabbits, 1 of 8 (12.5%) flurbiprofen-treated rabbits, 1 of 8 (12.5%) NDGA-treated rabbits, and none of 8 vehicletreated rabbits. None of the 31 rabbits infected with Streptococcus pneumoniae experienced recurrence. These data confirm the clinical observation that Pseudomonas keratitis may recur if antibiotic therapy is discontinued and corticosteroids are administered; the risk of recurrence appears to be much less with nonsteroidal antiinflammatory agents.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</subject><subject>Cornea - microbiology</subject><subject>Disease Models, Animal</subject><subject>Eye Infections, Bacterial - drug therapy</subject><subject>Keratitis - drug therapy</subject><subject>Keratitis - microbiology</subject><subject>Methylprednisolone - therapeutic use</subject><subject>Pneumococcal Infections - drug therapy</subject><subject>Pseudomonas aeruginosa - growth & development</subject><subject>Pseudomonas Infections - drug therapy</subject><subject>Rabbits</subject><subject>Random Allocation</subject><subject>Recurrence</subject><subject>Streptococcus pneumoniae - growth & development</subject><subject>Tobramycin - therapeutic use</subject><issn>0277-3740</issn><issn>1536-4798</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UclOHDEQtaIgmJB8QiSfuHXipb30EY3IooCQEJyNx67WOHG3wXZrxN_jyZBwoi6lqvdqe4UQpuQLJYP6SppxxmRHh4GRoUXdPqXfoRUVXHa9GvR7tCJMqY6rnpygD6X8bgylJDtGx7RnvZR6he5vwC05w-wApxFfBZfTJtiIf0G2NdRQ8DrNLk2h2rniXahbfD7XEOYx2mmyNeUnfJvB1gkaHmZs50YIU2txlTzEj-hotLHApxd_iu6-Xdyuf3SX199_rs8vO8eF0B2XDnoigHGqqZeeDd5rS4SwbJTcaxBWW8o8lXwQG-2cULznZPBcWfBg-Sk6O_R9yOlxgVLNFIqDGO0MaSlGcaZFL3Qj6gOxXVpKhtE85LZufjKUmL245p-45r-4f1P70s8vM5bNBP618KBmw_sDvkuxQi5_4rKDbLZgY92at37GnwHkw4T3</recordid><startdate>199209</startdate><enddate>199209</enddate><creator>Gritz, David C</creator><creator>Kwitko, Sergio</creator><creator>Trousdale, Melvin D</creator><creator>Gonzalez, Victor H</creator><creator>McDonnell, Peter J</creator><general>Lippincott-Raven Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199209</creationdate><title>Recurrence of Microbial Keratitis Concomitant with Antiinflammatory Treatment in an Animal Model</title><author>Gritz, David C ; Kwitko, Sergio ; Trousdale, Melvin D ; Gonzalez, Victor H ; McDonnell, Peter J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3558-36ce405e23181d6d29dd8a055a2f63d8e5a8a12d16395b8cc5734309d37aedea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</topic><topic>Cornea - microbiology</topic><topic>Disease Models, Animal</topic><topic>Eye Infections, Bacterial - drug therapy</topic><topic>Keratitis - drug therapy</topic><topic>Keratitis - microbiology</topic><topic>Methylprednisolone - therapeutic use</topic><topic>Pneumococcal Infections - drug therapy</topic><topic>Pseudomonas aeruginosa - growth & development</topic><topic>Pseudomonas Infections - drug therapy</topic><topic>Rabbits</topic><topic>Random Allocation</topic><topic>Recurrence</topic><topic>Streptococcus pneumoniae - growth & development</topic><topic>Tobramycin - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gritz, David C</creatorcontrib><creatorcontrib>Kwitko, Sergio</creatorcontrib><creatorcontrib>Trousdale, Melvin D</creatorcontrib><creatorcontrib>Gonzalez, Victor H</creatorcontrib><creatorcontrib>McDonnell, Peter J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cornea</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gritz, David C</au><au>Kwitko, Sergio</au><au>Trousdale, Melvin D</au><au>Gonzalez, Victor H</au><au>McDonnell, Peter J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recurrence of Microbial Keratitis Concomitant with Antiinflammatory Treatment in an Animal Model</atitle><jtitle>Cornea</jtitle><addtitle>Cornea</addtitle><date>1992-09</date><risdate>1992</risdate><volume>11</volume><issue>5</issue><spage>404</spage><epage>408</epage><pages>404-408</pages><issn>0277-3740</issn><eissn>1536-4798</eissn><abstract>Recurrence of Pseudomonas keratitis during treatment with corticosteroids has been reported previously in humans. Rabbits with keratitis due to Pseudomonas aeruginosa or Streptococcus pneumoniae were treated with antibiotics and either vehicle, methylprednisolone acetate, flurbiprofen, or nordihydroguaiaretic acid (NDGA). Cultures performed after 7 days were negative, and antibiotics were discontinued. Two weeks later, Pseudomonas keratitis recurred in 6 of 7 (85.7%) steroid-treated rabbits, 1 of 8 (12.5%) flurbiprofen-treated rabbits, 1 of 8 (12.5%) NDGA-treated rabbits, and none of 8 vehicletreated rabbits. None of the 31 rabbits infected with Streptococcus pneumoniae experienced recurrence. These data confirm the clinical observation that Pseudomonas keratitis may recur if antibiotic therapy is discontinued and corticosteroids are administered; the risk of recurrence appears to be much less with nonsteroidal antiinflammatory agents.</abstract><cop>United States</cop><pub>Lippincott-Raven Publishers</pub><pmid>1424668</pmid><doi>10.1097/00003226-199209000-00008</doi><tpages>5</tpages></addata></record> |
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| ispartof | Cornea, 1992-09, Vol.11 (5), p.404-408 |
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| language | eng |
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| source | Journals@Ovid Ovid Autoload; MEDLINE |
| subjects | Animals Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Cornea - microbiology Disease Models, Animal Eye Infections, Bacterial - drug therapy Keratitis - drug therapy Keratitis - microbiology Methylprednisolone - therapeutic use Pneumococcal Infections - drug therapy Pseudomonas aeruginosa - growth & development Pseudomonas Infections - drug therapy Rabbits Random Allocation Recurrence Streptococcus pneumoniae - growth & development Tobramycin - therapeutic use |
| title | Recurrence of Microbial Keratitis Concomitant with Antiinflammatory Treatment in an Animal Model |
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