Does the beneficial effect of HRT on endothelial function depend on lipid changes
Objectives: To determine whether improvement in endothelial function of the brachial artery observed in women treated with hormone replacement therapy (HRT) may be explained by changes in lipid profile or blood pressure, information was used obtained in a single-centre, randomised, double blind, pla...
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| Veröffentlicht in: | Maturitas 2003-05, Vol.45 (1), p.47-54 |
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| creator | Ossewaarde, Marlies E. Bots, Michiel L. van der Schouw, Yvonne T. de Kleijn, Miriam J.J. Wilmink, Hanneke W. Bak, Annette A.A. Planellas, Juan Banga, Jan-Dirk Grobbee, Diederick E. |
| description | Objectives: To determine whether improvement in endothelial function of the brachial artery observed in women treated with hormone replacement therapy (HRT) may be explained by changes in lipid profile or blood pressure, information was used obtained in a single-centre, randomised, double blind, placebo-controlled trial.
Methods: Hundred-and-five healthy postmenopausal women, aged 50–65 years, were treated with 0.625 mg conjugated equine estrogens (CEE) combined with 2.5 mg medroxyprogesterone acetate (MPA) (CEE+MPA), 2.5 mg tibolone or placebo for 3 months. At baseline and after 3 months, endothelial function was assessed using flow-mediated dilatation (FMD) and nitro glycerine-mediated dilatation (NMD). Furthermore, lipids were measured. Multivariate linear regression analysis was applied to address the research question.
Results: Treatment with CEE+MPA resulted in an improvement in FMD of 2.0% (95% CI: −0.1; 4.1). CEE/MPA reduced total cholesterol with 13% (95% CI: −18%; −7%), LDL-cholesterol with 23% (95% CI: −30%; −15%) and lipoprotein(a) (Lp(a)) with 14% (95% CI: −26%; −2%). The magnitude of the relation of CEE/MPA with endothelial function was attenuated to from 2.0 to 1.6% when change in Lp(a) was taken into account. Adjustments for other lipids or blood pressure did not attenuate the association.
Conclusions: The improvement in endothelial function in postmenopausal women treated with CEE+MPA appears to be partially mediated by change in Lp(a), and apparently not by changes in other lipids. |
| doi_str_mv | 10.1016/S0378-5122(03)00085-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73285205</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0378512203000859</els_id><sourcerecordid>73285205</sourcerecordid><originalsourceid>FETCH-LOGICAL-c391t-59b3eb8c19bbbe2dd4da5438287b2e1b357337e74e0fe592607f70dc0a374c153</originalsourceid><addsrcrecordid>eNqFkMtKw0AUhgdRbL08gpKNoovoXDKdZCVSLxUKotb1MJczdiRNaiYRfHsnbbFLVwf-850LH0InBF8RTEbXb5iJPOWE0gvMLjHGOU-LHTQkuWBpRgjZRcM_ZIAOQviMEMcs20cDQgVnRcaG6OWuhpC0c0g0VOC88apMwDkwbVK7ZPI6S-oqgcrWkSn7pusq0_oYWljGvG-XfultYuaq-oBwhPacKgMcb-ohen-4n40n6fT58Wl8O00NK0ib8kIz0LkhhdYaqLWZVTxjOc2FpkA044IxASID7IAXdISFE9garJjIDOHsEJ2v9y6b-quD0MqFDwbKUlVQd0EKRnNOcQ_yNWiaOoQGnFw2fqGaH0mw7F3KlUvZi5KYyZVLWcS5082BTi_Abqc28iJwtgFUMKp0jaqMD1suEznlnETuZs1B1PHtoZHBeKgMWN9Ez9LW_p9XfgGFlI9-</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>73285205</pqid></control><display><type>article</type><title>Does the beneficial effect of HRT on endothelial function depend on lipid changes</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Ossewaarde, Marlies E. ; Bots, Michiel L. ; van der Schouw, Yvonne T. ; de Kleijn, Miriam J.J. ; Wilmink, Hanneke W. ; Bak, Annette A.A. ; Planellas, Juan ; Banga, Jan-Dirk ; Grobbee, Diederick E.</creator><creatorcontrib>Ossewaarde, Marlies E. ; Bots, Michiel L. ; van der Schouw, Yvonne T. ; de Kleijn, Miriam J.J. ; Wilmink, Hanneke W. ; Bak, Annette A.A. ; Planellas, Juan ; Banga, Jan-Dirk ; Grobbee, Diederick E.</creatorcontrib><description>Objectives: To determine whether improvement in endothelial function of the brachial artery observed in women treated with hormone replacement therapy (HRT) may be explained by changes in lipid profile or blood pressure, information was used obtained in a single-centre, randomised, double blind, placebo-controlled trial.
Methods: Hundred-and-five healthy postmenopausal women, aged 50–65 years, were treated with 0.625 mg conjugated equine estrogens (CEE) combined with 2.5 mg medroxyprogesterone acetate (MPA) (CEE+MPA), 2.5 mg tibolone or placebo for 3 months. At baseline and after 3 months, endothelial function was assessed using flow-mediated dilatation (FMD) and nitro glycerine-mediated dilatation (NMD). Furthermore, lipids were measured. Multivariate linear regression analysis was applied to address the research question.
Results: Treatment with CEE+MPA resulted in an improvement in FMD of 2.0% (95% CI: −0.1; 4.1). CEE/MPA reduced total cholesterol with 13% (95% CI: −18%; −7%), LDL-cholesterol with 23% (95% CI: −30%; −15%) and lipoprotein(a) (Lp(a)) with 14% (95% CI: −26%; −2%). The magnitude of the relation of CEE/MPA with endothelial function was attenuated to from 2.0 to 1.6% when change in Lp(a) was taken into account. Adjustments for other lipids or blood pressure did not attenuate the association.
Conclusions: The improvement in endothelial function in postmenopausal women treated with CEE+MPA appears to be partially mediated by change in Lp(a), and apparently not by changes in other lipids.</description><identifier>ISSN: 0378-5122</identifier><identifier>EISSN: 1873-4111</identifier><identifier>DOI: 10.1016/S0378-5122(03)00085-9</identifier><identifier>PMID: 12753943</identifier><identifier>CODEN: MATUDK</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Aged ; Biological and medical sciences ; Blood pressure ; Blood Pressure - drug effects ; Brachial Artery - drug effects ; Brachial Artery - physiology ; Cholesterol - blood ; Cholesterol, LDL - blood ; Double-Blind Method ; Endothelial function ; Endothelium, Vascular - drug effects ; Estrogen Replacement Therapy ; Estrogens, Conjugated (USP) - pharmacology ; Female ; Hormone replacement therapy ; Hormones. Endocrine system ; Humans ; Lipids ; Lipoprotein(a) - blood ; Medical sciences ; Medroxyprogesterone Acetate - pharmacology ; Middle Aged ; Norpregnenes - pharmacology ; Pharmacology. Drug treatments ; Pulsatile Flow - drug effects</subject><ispartof>Maturitas, 2003-05, Vol.45 (1), p.47-54</ispartof><rights>2003 Elsevier Science Ireland Ltd</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-59b3eb8c19bbbe2dd4da5438287b2e1b357337e74e0fe592607f70dc0a374c153</citedby><cites>FETCH-LOGICAL-c391t-59b3eb8c19bbbe2dd4da5438287b2e1b357337e74e0fe592607f70dc0a374c153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378512203000859$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14782551$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12753943$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ossewaarde, Marlies E.</creatorcontrib><creatorcontrib>Bots, Michiel L.</creatorcontrib><creatorcontrib>van der Schouw, Yvonne T.</creatorcontrib><creatorcontrib>de Kleijn, Miriam J.J.</creatorcontrib><creatorcontrib>Wilmink, Hanneke W.</creatorcontrib><creatorcontrib>Bak, Annette A.A.</creatorcontrib><creatorcontrib>Planellas, Juan</creatorcontrib><creatorcontrib>Banga, Jan-Dirk</creatorcontrib><creatorcontrib>Grobbee, Diederick E.</creatorcontrib><title>Does the beneficial effect of HRT on endothelial function depend on lipid changes</title><title>Maturitas</title><addtitle>Maturitas</addtitle><description>Objectives: To determine whether improvement in endothelial function of the brachial artery observed in women treated with hormone replacement therapy (HRT) may be explained by changes in lipid profile or blood pressure, information was used obtained in a single-centre, randomised, double blind, placebo-controlled trial.
Methods: Hundred-and-five healthy postmenopausal women, aged 50–65 years, were treated with 0.625 mg conjugated equine estrogens (CEE) combined with 2.5 mg medroxyprogesterone acetate (MPA) (CEE+MPA), 2.5 mg tibolone or placebo for 3 months. At baseline and after 3 months, endothelial function was assessed using flow-mediated dilatation (FMD) and nitro glycerine-mediated dilatation (NMD). Furthermore, lipids were measured. Multivariate linear regression analysis was applied to address the research question.
Results: Treatment with CEE+MPA resulted in an improvement in FMD of 2.0% (95% CI: −0.1; 4.1). CEE/MPA reduced total cholesterol with 13% (95% CI: −18%; −7%), LDL-cholesterol with 23% (95% CI: −30%; −15%) and lipoprotein(a) (Lp(a)) with 14% (95% CI: −26%; −2%). The magnitude of the relation of CEE/MPA with endothelial function was attenuated to from 2.0 to 1.6% when change in Lp(a) was taken into account. Adjustments for other lipids or blood pressure did not attenuate the association.
Conclusions: The improvement in endothelial function in postmenopausal women treated with CEE+MPA appears to be partially mediated by change in Lp(a), and apparently not by changes in other lipids.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Blood pressure</subject><subject>Blood Pressure - drug effects</subject><subject>Brachial Artery - drug effects</subject><subject>Brachial Artery - physiology</subject><subject>Cholesterol - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Double-Blind Method</subject><subject>Endothelial function</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Estrogen Replacement Therapy</subject><subject>Estrogens, Conjugated (USP) - pharmacology</subject><subject>Female</subject><subject>Hormone replacement therapy</subject><subject>Hormones. Endocrine system</subject><subject>Humans</subject><subject>Lipids</subject><subject>Lipoprotein(a) - blood</subject><subject>Medical sciences</subject><subject>Medroxyprogesterone Acetate - pharmacology</subject><subject>Middle Aged</subject><subject>Norpregnenes - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Pulsatile Flow - drug effects</subject><issn>0378-5122</issn><issn>1873-4111</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKw0AUhgdRbL08gpKNoovoXDKdZCVSLxUKotb1MJczdiRNaiYRfHsnbbFLVwf-850LH0InBF8RTEbXb5iJPOWE0gvMLjHGOU-LHTQkuWBpRgjZRcM_ZIAOQviMEMcs20cDQgVnRcaG6OWuhpC0c0g0VOC88apMwDkwbVK7ZPI6S-oqgcrWkSn7pusq0_oYWljGvG-XfultYuaq-oBwhPacKgMcb-ohen-4n40n6fT58Wl8O00NK0ib8kIz0LkhhdYaqLWZVTxjOc2FpkA044IxASID7IAXdISFE9garJjIDOHsEJ2v9y6b-quD0MqFDwbKUlVQd0EKRnNOcQ_yNWiaOoQGnFw2fqGaH0mw7F3KlUvZi5KYyZVLWcS5082BTi_Abqc28iJwtgFUMKp0jaqMD1suEznlnETuZs1B1PHtoZHBeKgMWN9Ez9LW_p9XfgGFlI9-</recordid><startdate>20030530</startdate><enddate>20030530</enddate><creator>Ossewaarde, Marlies E.</creator><creator>Bots, Michiel L.</creator><creator>van der Schouw, Yvonne T.</creator><creator>de Kleijn, Miriam J.J.</creator><creator>Wilmink, Hanneke W.</creator><creator>Bak, Annette A.A.</creator><creator>Planellas, Juan</creator><creator>Banga, Jan-Dirk</creator><creator>Grobbee, Diederick E.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030530</creationdate><title>Does the beneficial effect of HRT on endothelial function depend on lipid changes</title><author>Ossewaarde, Marlies E. ; Bots, Michiel L. ; van der Schouw, Yvonne T. ; de Kleijn, Miriam J.J. ; Wilmink, Hanneke W. ; Bak, Annette A.A. ; Planellas, Juan ; Banga, Jan-Dirk ; Grobbee, Diederick E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-59b3eb8c19bbbe2dd4da5438287b2e1b357337e74e0fe592607f70dc0a374c153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Blood pressure</topic><topic>Blood Pressure - drug effects</topic><topic>Brachial Artery - drug effects</topic><topic>Brachial Artery - physiology</topic><topic>Cholesterol - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Double-Blind Method</topic><topic>Endothelial function</topic><topic>Endothelium, Vascular - drug effects</topic><topic>Estrogen Replacement Therapy</topic><topic>Estrogens, Conjugated (USP) - pharmacology</topic><topic>Female</topic><topic>Hormone replacement therapy</topic><topic>Hormones. Endocrine system</topic><topic>Humans</topic><topic>Lipids</topic><topic>Lipoprotein(a) - blood</topic><topic>Medical sciences</topic><topic>Medroxyprogesterone Acetate - pharmacology</topic><topic>Middle Aged</topic><topic>Norpregnenes - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Pulsatile Flow - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ossewaarde, Marlies E.</creatorcontrib><creatorcontrib>Bots, Michiel L.</creatorcontrib><creatorcontrib>van der Schouw, Yvonne T.</creatorcontrib><creatorcontrib>de Kleijn, Miriam J.J.</creatorcontrib><creatorcontrib>Wilmink, Hanneke W.</creatorcontrib><creatorcontrib>Bak, Annette A.A.</creatorcontrib><creatorcontrib>Planellas, Juan</creatorcontrib><creatorcontrib>Banga, Jan-Dirk</creatorcontrib><creatorcontrib>Grobbee, Diederick E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Maturitas</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ossewaarde, Marlies E.</au><au>Bots, Michiel L.</au><au>van der Schouw, Yvonne T.</au><au>de Kleijn, Miriam J.J.</au><au>Wilmink, Hanneke W.</au><au>Bak, Annette A.A.</au><au>Planellas, Juan</au><au>Banga, Jan-Dirk</au><au>Grobbee, Diederick E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does the beneficial effect of HRT on endothelial function depend on lipid changes</atitle><jtitle>Maturitas</jtitle><addtitle>Maturitas</addtitle><date>2003-05-30</date><risdate>2003</risdate><volume>45</volume><issue>1</issue><spage>47</spage><epage>54</epage><pages>47-54</pages><issn>0378-5122</issn><eissn>1873-4111</eissn><coden>MATUDK</coden><abstract>Objectives: To determine whether improvement in endothelial function of the brachial artery observed in women treated with hormone replacement therapy (HRT) may be explained by changes in lipid profile or blood pressure, information was used obtained in a single-centre, randomised, double blind, placebo-controlled trial.
Methods: Hundred-and-five healthy postmenopausal women, aged 50–65 years, were treated with 0.625 mg conjugated equine estrogens (CEE) combined with 2.5 mg medroxyprogesterone acetate (MPA) (CEE+MPA), 2.5 mg tibolone or placebo for 3 months. At baseline and after 3 months, endothelial function was assessed using flow-mediated dilatation (FMD) and nitro glycerine-mediated dilatation (NMD). Furthermore, lipids were measured. Multivariate linear regression analysis was applied to address the research question.
Results: Treatment with CEE+MPA resulted in an improvement in FMD of 2.0% (95% CI: −0.1; 4.1). CEE/MPA reduced total cholesterol with 13% (95% CI: −18%; −7%), LDL-cholesterol with 23% (95% CI: −30%; −15%) and lipoprotein(a) (Lp(a)) with 14% (95% CI: −26%; −2%). The magnitude of the relation of CEE/MPA with endothelial function was attenuated to from 2.0 to 1.6% when change in Lp(a) was taken into account. Adjustments for other lipids or blood pressure did not attenuate the association.
Conclusions: The improvement in endothelial function in postmenopausal women treated with CEE+MPA appears to be partially mediated by change in Lp(a), and apparently not by changes in other lipids.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>12753943</pmid><doi>10.1016/S0378-5122(03)00085-9</doi><tpages>8</tpages></addata></record> |
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| subjects | Aged Biological and medical sciences Blood pressure Blood Pressure - drug effects Brachial Artery - drug effects Brachial Artery - physiology Cholesterol - blood Cholesterol, LDL - blood Double-Blind Method Endothelial function Endothelium, Vascular - drug effects Estrogen Replacement Therapy Estrogens, Conjugated (USP) - pharmacology Female Hormone replacement therapy Hormones. Endocrine system Humans Lipids Lipoprotein(a) - blood Medical sciences Medroxyprogesterone Acetate - pharmacology Middle Aged Norpregnenes - pharmacology Pharmacology. Drug treatments Pulsatile Flow - drug effects |
| title | Does the beneficial effect of HRT on endothelial function depend on lipid changes |
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