Effect of Levovist® on splanchnic hemodynamics in cirrhotic patients
This study was aimed to assess the effect of Levovist® on Doppler parameters of splanchnic hemodynamics. A total of 12 patients with cirrhosis and 12 healthy subjects underwent Doppler ultrasound (US) examination of the portal vein and of the hepatic, splenic and superior mesenteric arteries before,...
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| Veröffentlicht in: | Ultrasound in medicine & biology 2003-05, Vol.29 (5), p.643-648 |
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| creator | Gaiani, Stefano Serra, Carla Piscaglia, Fabio Celli, Natascia Rasciti, Leonardo Miglioli, Mario Bolondi, Luigi |
| description | This study was aimed to assess the effect of Levovist® on Doppler parameters of splanchnic hemodynamics. A total of 12 patients with cirrhosis and 12 healthy subjects underwent Doppler ultrasound (US) examination of the portal vein and of the hepatic, splenic and superior mesenteric arteries before, 5 to 8 and 12 to 15 min after the start of an 8-min long IV infusion of 2.5 g of Levovist®. Mean velocity and mean diameter were calculated for the portal vein. Resistance index was determined for the arteries. A significant increase of resistance index was observed in the hepatic (0.80 ± 0.07 vs. 0.71 ± 0.06;
p < 0.01) and splenic arteries (0.72 ± 0.06 vs. 0.64 ± 0.06;
p < 0.01) 5 to 8 min after contrast agent injection in patients with cirrhosis, but not in controls. Neither portal vein diameter nor portal flow mean velocity changed during the test in both controls and cirrhotic patients. This effect might be related to a selective trapping of microbubbles in the altered hepatic and splenic microvasculature in patients with cirrhosis rather than being artefactual. It might have implications on harmonic imaging US protocols designed to image the cirrhotic liver in the early arterial phase. (E-mail: sgaiani@med.unibo.it) |
| doi_str_mv | 10.1016/S0301-5629(02)00793-7 |
| format | Article |
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p < 0.01) and splenic arteries (0.72 ± 0.06 vs. 0.64 ± 0.06;
p < 0.01) 5 to 8 min after contrast agent injection in patients with cirrhosis, but not in controls. Neither portal vein diameter nor portal flow mean velocity changed during the test in both controls and cirrhotic patients. This effect might be related to a selective trapping of microbubbles in the altered hepatic and splenic microvasculature in patients with cirrhosis rather than being artefactual. It might have implications on harmonic imaging US protocols designed to image the cirrhotic liver in the early arterial phase. (E-mail: sgaiani@med.unibo.it)</description><identifier>ISSN: 0301-5629</identifier><identifier>EISSN: 1879-291X</identifier><identifier>DOI: 10.1016/S0301-5629(02)00793-7</identifier><identifier>PMID: 12754063</identifier><identifier>CODEN: USMBA3</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Aged ; Biological and medical sciences ; Cirrhosis ; Contrast agent (ultrasound) ; Contrast Media - pharmacology ; Contrast media. Radiopharmaceuticals ; Digestive system. Abdomen ; Doppler (ultrasonography) ; Female ; Hemodynamics - drug effects ; Hepatic Artery - diagnostic imaging ; Hepatic Artery - drug effects ; Hepatic Artery - physiopathology ; Hepatic resistance ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Liver Cirrhosis - diagnostic imaging ; Liver Cirrhosis - physiopathology ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Polysaccharides - pharmacology ; Portal hypertension ; Resistance index ; Splanchnic Circulation - drug effects ; Splenic Artery - diagnostic imaging ; Splenic Artery - drug effects ; Splenic Artery - physiopathology ; Ultrasonic investigative techniques ; Ultrasonography, Doppler ; Vascular Resistance - drug effects</subject><ispartof>Ultrasound in medicine & biology, 2003-05, Vol.29 (5), p.643-648</ispartof><rights>2003 World Federation for Ultrasound in Medicine & Biology</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-2f360050273b589d41dc4097f2e38958d8d897d2d9509fe006580cc11d8db21a3</citedby><cites>FETCH-LOGICAL-c422t-2f360050273b589d41dc4097f2e38958d8d897d2d9509fe006580cc11d8db21a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0301-5629(02)00793-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3554,27933,27934,46004</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14783241$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12754063$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gaiani, Stefano</creatorcontrib><creatorcontrib>Serra, Carla</creatorcontrib><creatorcontrib>Piscaglia, Fabio</creatorcontrib><creatorcontrib>Celli, Natascia</creatorcontrib><creatorcontrib>Rasciti, Leonardo</creatorcontrib><creatorcontrib>Miglioli, Mario</creatorcontrib><creatorcontrib>Bolondi, Luigi</creatorcontrib><title>Effect of Levovist® on splanchnic hemodynamics in cirrhotic patients</title><title>Ultrasound in medicine & biology</title><addtitle>Ultrasound Med Biol</addtitle><description>This study was aimed to assess the effect of Levovist® on Doppler parameters of splanchnic hemodynamics. A total of 12 patients with cirrhosis and 12 healthy subjects underwent Doppler ultrasound (US) examination of the portal vein and of the hepatic, splenic and superior mesenteric arteries before, 5 to 8 and 12 to 15 min after the start of an 8-min long IV infusion of 2.5 g of Levovist®. Mean velocity and mean diameter were calculated for the portal vein. Resistance index was determined for the arteries. A significant increase of resistance index was observed in the hepatic (0.80 ± 0.07 vs. 0.71 ± 0.06;
p < 0.01) and splenic arteries (0.72 ± 0.06 vs. 0.64 ± 0.06;
p < 0.01) 5 to 8 min after contrast agent injection in patients with cirrhosis, but not in controls. Neither portal vein diameter nor portal flow mean velocity changed during the test in both controls and cirrhotic patients. This effect might be related to a selective trapping of microbubbles in the altered hepatic and splenic microvasculature in patients with cirrhosis rather than being artefactual. It might have implications on harmonic imaging US protocols designed to image the cirrhotic liver in the early arterial phase. (E-mail: sgaiani@med.unibo.it)</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cirrhosis</subject><subject>Contrast agent (ultrasound)</subject><subject>Contrast Media - pharmacology</subject><subject>Contrast media. Radiopharmaceuticals</subject><subject>Digestive system. Abdomen</subject><subject>Doppler (ultrasonography)</subject><subject>Female</subject><subject>Hemodynamics - drug effects</subject><subject>Hepatic Artery - diagnostic imaging</subject><subject>Hepatic Artery - drug effects</subject><subject>Hepatic Artery - physiopathology</subject><subject>Hepatic resistance</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Liver Cirrhosis - diagnostic imaging</subject><subject>Liver Cirrhosis - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Polysaccharides - pharmacology</subject><subject>Portal hypertension</subject><subject>Resistance index</subject><subject>Splanchnic Circulation - drug effects</subject><subject>Splenic Artery - diagnostic imaging</subject><subject>Splenic Artery - drug effects</subject><subject>Splenic Artery - physiopathology</subject><subject>Ultrasonic investigative techniques</subject><subject>Ultrasonography, Doppler</subject><subject>Vascular Resistance - drug effects</subject><issn>0301-5629</issn><issn>1879-291X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1KAzEQx4MotlYfQdmLoofVSbK72ZxESv2AggcVvIVtPmiku6nJttCX8iF8MtN2sceSwxzmN_MffkHoHMMtBlzcvQEFnOYF4ddAbgAYpyk7QH1cMp4Sjj8PUf8f6aGTEL4gUgVlx6iHCcszKGgfjUbGaNkmziRjvXRLG9rfn8Q1SZjPqkZOGyuTqa6dWjVVbWVIbJNI6_3UtbEzr1qrmzacoiNTzYI-6-oAfTyO3ofP6fj16WX4ME5lRkibEkMLgBwIo5O85CrDSmbAmSGaljwvVXycKaJ4DtxogCIvQUqMY2NCcEUH6Gq7d-7d90KHVtQ2SD2Lp2q3CIJRUtIS2F4wWsoIJVkE8y0ovQvBayPm3taVXwkMYi1abESLtUUBRGxEi3XARRewmNRa7aY6sxG47IAqyGpmfLRpw47LWBnzceTut5yO3pZWexFkdCq1sj5-jFDO7jnlD_UUmYM</recordid><startdate>20030501</startdate><enddate>20030501</enddate><creator>Gaiani, Stefano</creator><creator>Serra, Carla</creator><creator>Piscaglia, Fabio</creator><creator>Celli, Natascia</creator><creator>Rasciti, Leonardo</creator><creator>Miglioli, Mario</creator><creator>Bolondi, Luigi</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20030501</creationdate><title>Effect of Levovist® on splanchnic hemodynamics in cirrhotic patients</title><author>Gaiani, Stefano ; Serra, Carla ; Piscaglia, Fabio ; Celli, Natascia ; Rasciti, Leonardo ; Miglioli, Mario ; Bolondi, Luigi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-2f360050273b589d41dc4097f2e38958d8d897d2d9509fe006580cc11d8db21a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cirrhosis</topic><topic>Contrast agent (ultrasound)</topic><topic>Contrast Media - pharmacology</topic><topic>Contrast media. Radiopharmaceuticals</topic><topic>Digestive system. Abdomen</topic><topic>Doppler (ultrasonography)</topic><topic>Female</topic><topic>Hemodynamics - drug effects</topic><topic>Hepatic Artery - diagnostic imaging</topic><topic>Hepatic Artery - drug effects</topic><topic>Hepatic Artery - physiopathology</topic><topic>Hepatic resistance</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Liver Cirrhosis - diagnostic imaging</topic><topic>Liver Cirrhosis - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Polysaccharides - pharmacology</topic><topic>Portal hypertension</topic><topic>Resistance index</topic><topic>Splanchnic Circulation - drug effects</topic><topic>Splenic Artery - diagnostic imaging</topic><topic>Splenic Artery - drug effects</topic><topic>Splenic Artery - physiopathology</topic><topic>Ultrasonic investigative techniques</topic><topic>Ultrasonography, Doppler</topic><topic>Vascular Resistance - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gaiani, Stefano</creatorcontrib><creatorcontrib>Serra, Carla</creatorcontrib><creatorcontrib>Piscaglia, Fabio</creatorcontrib><creatorcontrib>Celli, Natascia</creatorcontrib><creatorcontrib>Rasciti, Leonardo</creatorcontrib><creatorcontrib>Miglioli, Mario</creatorcontrib><creatorcontrib>Bolondi, Luigi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Ultrasound in medicine & biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gaiani, Stefano</au><au>Serra, Carla</au><au>Piscaglia, Fabio</au><au>Celli, Natascia</au><au>Rasciti, Leonardo</au><au>Miglioli, Mario</au><au>Bolondi, Luigi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Levovist® on splanchnic hemodynamics in cirrhotic patients</atitle><jtitle>Ultrasound in medicine & biology</jtitle><addtitle>Ultrasound Med Biol</addtitle><date>2003-05-01</date><risdate>2003</risdate><volume>29</volume><issue>5</issue><spage>643</spage><epage>648</epage><pages>643-648</pages><issn>0301-5629</issn><eissn>1879-291X</eissn><coden>USMBA3</coden><abstract>This study was aimed to assess the effect of Levovist® on Doppler parameters of splanchnic hemodynamics. A total of 12 patients with cirrhosis and 12 healthy subjects underwent Doppler ultrasound (US) examination of the portal vein and of the hepatic, splenic and superior mesenteric arteries before, 5 to 8 and 12 to 15 min after the start of an 8-min long IV infusion of 2.5 g of Levovist®. Mean velocity and mean diameter were calculated for the portal vein. Resistance index was determined for the arteries. A significant increase of resistance index was observed in the hepatic (0.80 ± 0.07 vs. 0.71 ± 0.06;
p < 0.01) and splenic arteries (0.72 ± 0.06 vs. 0.64 ± 0.06;
p < 0.01) 5 to 8 min after contrast agent injection in patients with cirrhosis, but not in controls. Neither portal vein diameter nor portal flow mean velocity changed during the test in both controls and cirrhotic patients. This effect might be related to a selective trapping of microbubbles in the altered hepatic and splenic microvasculature in patients with cirrhosis rather than being artefactual. It might have implications on harmonic imaging US protocols designed to image the cirrhotic liver in the early arterial phase. (E-mail: sgaiani@med.unibo.it)</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>12754063</pmid><doi>10.1016/S0301-5629(02)00793-7</doi><tpages>6</tpages></addata></record> |
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| ispartof | Ultrasound in medicine & biology, 2003-05, Vol.29 (5), p.643-648 |
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| subjects | Aged Biological and medical sciences Cirrhosis Contrast agent (ultrasound) Contrast Media - pharmacology Contrast media. Radiopharmaceuticals Digestive system. Abdomen Doppler (ultrasonography) Female Hemodynamics - drug effects Hepatic Artery - diagnostic imaging Hepatic Artery - drug effects Hepatic Artery - physiopathology Hepatic resistance Humans Investigative techniques, diagnostic techniques (general aspects) Liver Cirrhosis - diagnostic imaging Liver Cirrhosis - physiopathology Male Medical sciences Middle Aged Pharmacology. Drug treatments Polysaccharides - pharmacology Portal hypertension Resistance index Splanchnic Circulation - drug effects Splenic Artery - diagnostic imaging Splenic Artery - drug effects Splenic Artery - physiopathology Ultrasonic investigative techniques Ultrasonography, Doppler Vascular Resistance - drug effects |
| title | Effect of Levovist® on splanchnic hemodynamics in cirrhotic patients |
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