The effect of age on inducibility of various types of rat liver cytochrome P-450

1. The content and specific activities of inducible cytochrome P-450 enzymes were determined in liver microscomes of rats of various ages after maximal induction with phenobarbital, isosafrole of 3-methylcholanthrene, and in untreated animals. 2. With age an increase in liver weight was observed bot...

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Veröffentlicht in:	Xenobiotica 1992, Vol.22 (5), p.515-522
Hauptverfasser:	Horbach, G. J. M., Van Asten, J. G., Rietjens, I. M. C. M., Kremers, P., Van Bezooijen, C. F. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - metabolism Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Cytochrome P-450 CYP1A2 Cytochrome P-450 Enzyme System - biosynthesis Cytochrome P-450 Enzyme System - drug effects Cytochrome P-450 Enzyme System - metabolism Enzyme Induction Enzyme-Linked Immunosorbent Assay Fundamental and applied biological sciences. Psychology Hemoproteins Life Sciences & Biomedicine Liver - anatomy & histology Liver - enzymology Male Metalloproteins Methylcholanthrene - pharmacology Organ Size - physiology Oxidoreductases - biosynthesis Oxidoreductases - drug effects Oxidoreductases - metabolism Pharmacology & Pharmacy Phenobarbital - pharmacology Proteins Rats Rats, Inbred BN RNA, Messenger - metabolism Safrole - pharmacology Science & Technology Toxicology
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