Two modes of exocytosis from synaptosomes are differentially regulated by protein phosphatase types 2A and 2B

The inhibitors okadaic acid (OA), fostriecin (FOS) and cyclosporin A (CsA), were used to investigate the roles of protein phosphatases in regulating exocytosis in rat brain synaptosomes by measuring glutamate release and the release of the styryl dye FM 2‐10. Depolarization was induced by 30 mm KCl,...

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Veröffentlicht in:	Journal of neurochemistry 2003-06, Vol.85 (5), p.1190-1199
Hauptverfasser:	Baldwin, Monique L., Rostas, John A. P., Sim, Alistair T. R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain Chemistry Calcineurin - chemistry Calcineurin - metabolism Calcineurin Inhibitors Calcium - analysis Calcium - metabolism Cell physiology Cyclosporine - pharmacology Enzyme Inhibitors - pharmacology exocytosis Exocytosis - drug effects Exocytosis - physiology Fluorescent Dyes - chemistry FM 2‐10 Fundamental and applied biological sciences. Psychology glutamate Glutamic Acid - metabolism kiss‐and‐run Molecular and cellular biology Phosphoprotein Phosphatases - antagonists & inhibitors Phosphoprotein Phosphatases - chemistry Phosphoprotein Phosphatases - metabolism protein phosphatase Protein Phosphatase 2 Rats Secretion. Exocytosis synaptic vesicle Synaptosomes - chemistry Synaptosomes - drug effects Synaptosomes - enzymology
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