Relationship between natural killer activity and anger expression in patients with coronary heart disease
Recently, the contribution of the immune system in the development and progression of arteriosclerosis has been suggested. Moreover, psychological stress has also been reported to affect the immune response. Thus, psychological factors are considered to influence the immune response, and an excessiv...
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| Veröffentlicht in: | Heart and vessels 2003-05, Vol.18 (2), p.85-92 |
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| container_title | Heart and vessels |
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| creator | Ishihara, Shunichi Makita, Shigeru Imai, Masaru Hashimoto, Tetsuo Nohara, Ryuji |
| description | Recently, the contribution of the immune system in the development and progression of arteriosclerosis has been suggested. Moreover, psychological stress has also been reported to affect the immune response. Thus, psychological factors are considered to influence the immune response, and an excessive immune response promotes the progression of arteriosclerosis, resulting in the development of coronary heart disease (CHD). In this study, the relationship between the immune response and psychological factors was investigated in CHD patients (n = 74) and normal controls (n = 64). Natural killer (NK) activity was significantly higher in the CHD group than the normal control (CHD vs normal: 8151.39 vs 6653.06, P < 0.05), and was significantly elevated by the suppression of anger and negative emotions (P < 0.05). These results indicate that the characteristic process of psychological response in CHD patients is related to an overresponse of NK activity. We speculate that this linkage significantly influences the development of CHD. |
| doi_str_mv | 10.1007/s10380-002-0687-4 |
| format | Article |
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Moreover, psychological stress has also been reported to affect the immune response. Thus, psychological factors are considered to influence the immune response, and an excessive immune response promotes the progression of arteriosclerosis, resulting in the development of coronary heart disease (CHD). In this study, the relationship between the immune response and psychological factors was investigated in CHD patients (n = 74) and normal controls (n = 64). Natural killer (NK) activity was significantly higher in the CHD group than the normal control (CHD vs normal: 8151.39 vs 6653.06, P < 0.05), and was significantly elevated by the suppression of anger and negative emotions (P < 0.05). These results indicate that the characteristic process of psychological response in CHD patients is related to an overresponse of NK activity. 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| subjects | Adult Aged Analysis of Variance Anger Cardiology Cardiovascular disease Case-Control Studies Coronary Disease - immunology Coronary Disease - psychology Depressive Disorder - complications Depressive Disorder - psychology Expressed Emotion Female Heart Humans Immune system Killer Cells, Natural - immunology Male Middle Aged Psychological Tests Stress |
| title | Relationship between natural killer activity and anger expression in patients with coronary heart disease |
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