A mosaic adenovirus possessing serotype Ad5 and serotype Ad3 knobs exhibits expanded tropism

The efficiency of cancer gene therapy with recombinant adenoviruses based on serotype 5 (Ad5) has been limited partly because of variable, and often low, expression by human primary cancer cells of the primary cellular-receptor which recognizes the knob domain of the fiber protein, the coxsackie and...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2003-05, Vol.309 (2), p.282-293
Hauptverfasser:	Takayama, Koichi, Reynolds, Paul N., Short, Joshua J., Kawakami, Yosuke, Adachi, Yasuo, Glasgow, Joel N., Rots, Marianne G., Krasnykh, Victor, Douglas, Joanne T., Curiel, David T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ad3 Ad5 Adenovirus Adenoviruses, Human - genetics Adenoviruses, Human - pathogenicity Capsid Proteins - genetics Capsid Proteins - metabolism CAR Chimeric vector Coxsackie and Adenovirus Receptor-Like Membrane Protein Genetic Vectors HeLa Cells Humans Receptors, Virus - metabolism Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Recombination, Genetic Serotyping Tumor Cells, Cultured
Online-Zugang:	Volltext
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