AMPK β Subunit Targets Metabolic Stress Sensing to Glycogen

AMP-activated protein kinase (AMPK) is a multisubstrate enzyme activated by increases in AMP during metabolic stress caused by exercise, hypoxia, lack of cell nutrients [1], as well as hormones, including adiponectin and leptin [2, 3]. Furthermore, metformin and rosiglitazone, frontline drugs used f...

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Veröffentlicht in:	Current biology 2003-05, Vol.13 (10), p.867-871
Hauptverfasser:	Polekhina, Galina, Gupta, Abhilasha, Michell, Belinda J., van Denderen, Bryce, Murthy, Sid, Feil, Susanne C., Jennings, Ian G., Campbell, Duncan J., Witters, Lee A., Parker, Michael W., Kemp, Bruce E., Stapleton, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence AMP-Activated Protein Kinases Animals Gene Expression Glycogen - metabolism Glycogen - pharmacology Glycogen Phosphorylase - chemistry Glycogen Phosphorylase - genetics Glycogen Phosphorylase - metabolism Glycogen Synthase - metabolism Models, Molecular Molecular Sequence Data Multienzyme Complexes - chemistry Multienzyme Complexes - genetics Multienzyme Complexes - metabolism Multienzyme Complexes - ultrastructure Phylogeny Protein Binding Protein Structure, Tertiary Protein Subunits Protein-Serine-Threonine Kinases - chemistry Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Protein-Serine-Threonine Kinases - ultrastructure Rats Sequence Homology, Amino Acid Stress, Physiological - metabolism
Online-Zugang:	Volltext
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