Effect of the 5-HT3 receptor antagonist ondansetron on hypothalamic self-stimulation in rats and its interaction with the CCK analogue caerulein

It is unclear whether behavioral depression and suppression of food intake by cholecystokinin (CCK) is contributed to by aversive gastrointestinal effects such as nausea. In the present study we examined the effect of a new antiemetic agent, ondansetron, a specific antagonist of 5-HT3 receptors, on...

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Veröffentlicht in:	Neuroscience letters 1992-06, Vol.140 (1), p.16-18
Hauptverfasser:	HERBERG, L. J, DE BELLEROCHE, J. S, ROSE, I. C, MONTGOMERY, A. M. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Ceruletide - pharmacology Dose-Response Relationship, Drug Electric Stimulation Hypothalamus - drug effects Hypothalamus - physiology Male Medical sciences Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Ondansetron - pharmacology Pharmacology. Drug treatments Rats Rats, Wistar Receptors, Serotonin - physiology Self Stimulation - drug effects Serotonin Antagonists - pharmacology Serotoninergic system Time Factors
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