Magnetic resonance imaging of gastric cancer in Tff1 knock-out mice
In this work, the use of MRI to stage gastric neoplasia in a mouse model of spontaneous gastric cancer is demonstrated. The methodology involves 1) the use of deuterated water (2H2O) to distend the stomach, and to provide negative contrast between the stomach and the lumen without inducing susceptib...
Gespeichert in:
| Veröffentlicht in: | Magnetic resonance in medicine 2003-06, Vol.49 (6), p.1033-1036 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1036 |
|---|---|
| container_issue | 6 |
| container_start_page | 1033 |
| container_title | Magnetic resonance in medicine |
| container_volume | 49 |
| creator | Berr, Stuart S. Roche, James K. El-Rifai, Wa'el Smith Jr, Michael F. Powell, Steven M. |
| description | In this work, the use of MRI to stage gastric neoplasia in a mouse model of spontaneous gastric cancer is demonstrated. The methodology involves 1) the use of deuterated water (2H2O) to distend the stomach, and to provide negative contrast between the stomach and the lumen without inducing susceptibility‐based field shifts; 2) GlucaGen® to minimize motion artifacts that arise from peristalsis; and 3) Gd‐DTPA to enhance contrast between the dysplasia/tumor and the normal wall. Initial images are presented from a Tff1 −/− homozygous knock‐out model of gastric cancer and a heterozygous C57BL6/J control mouse. There are clear differences between the two types of animals in the MR appearance of the stomach. The distended stomach of the control mouse has a smooth perimeter and a thin wall, and an absence of nodules. The stomach of the Tff1 −/− mouse demonstrates a thickened wall; a jagged, irregular surface; and protruding nodules that are bright after injection of Gd‐DTPA. Magn Reson Med 49:1033–1036, 2003. © 2003 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/mrm.10458 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73279013</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>73279013</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4558-c9c2818ddab2386c8051af900c04abd385e8a58c2f81e314a18ed4c469ab4ddf3</originalsourceid><addsrcrecordid>eNqF0EtLKzEUB_AgitbHwi8gs1FwMZrnzMlSqreKrYJUXIY0k5TYeWgyxeu3v_G26kpcJXB-5xzOH6FDgs8IxvS8CU36cAEbaEAEpTkVkm-iAS45zhmRfAftxviMMZay5Ntoh9CyAAFkgIYTPW9t700WbOxa3Rqb-UbPfTvPOpfNdexDKpqPQsh8m02dI9mi7cwi75Z91nhj99GW03W0B-t3Dz3-uZoOr_Px_ehmeDHODRcCciMNBQJVpWeUQWEAC6KdxNhgrmcVA2FBCzDUAbGMcE3AVtzwQuoZryrH9tDJau5L6F6XNvaq8dHYutat7ZZRlYyWEhP2KyQgGWPAEzxdQRO6GIN16iWk68O7Ilh9RKtStOp_tMkerYcuZ42tvuU6ywSO10BHo2sXUmY-fjsOFBMhkztfuTdf2_efN6rJw-Rzdb7q8LG3f786dFioomSlUE93IzWF8eW4GN4qYP8A86Odtg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>18933384</pqid></control><display><type>article</type><title>Magnetic resonance imaging of gastric cancer in Tff1 knock-out mice</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><source>Wiley Online Library (Open Access Collection)</source><creator>Berr, Stuart S. ; Roche, James K. ; El-Rifai, Wa'el ; Smith Jr, Michael F. ; Powell, Steven M.</creator><creatorcontrib>Berr, Stuart S. ; Roche, James K. ; El-Rifai, Wa'el ; Smith Jr, Michael F. ; Powell, Steven M.</creatorcontrib><description>In this work, the use of MRI to stage gastric neoplasia in a mouse model of spontaneous gastric cancer is demonstrated. The methodology involves 1) the use of deuterated water (2H2O) to distend the stomach, and to provide negative contrast between the stomach and the lumen without inducing susceptibility‐based field shifts; 2) GlucaGen® to minimize motion artifacts that arise from peristalsis; and 3) Gd‐DTPA to enhance contrast between the dysplasia/tumor and the normal wall. Initial images are presented from a Tff1 −/− homozygous knock‐out model of gastric cancer and a heterozygous C57BL6/J control mouse. There are clear differences between the two types of animals in the MR appearance of the stomach. The distended stomach of the control mouse has a smooth perimeter and a thin wall, and an absence of nodules. The stomach of the Tff1 −/− mouse demonstrates a thickened wall; a jagged, irregular surface; and protruding nodules that are bright after injection of Gd‐DTPA. Magn Reson Med 49:1033–1036, 2003. © 2003 Wiley‐Liss, Inc.</description><identifier>ISSN: 0740-3194</identifier><identifier>EISSN: 1522-2594</identifier><identifier>DOI: 10.1002/mrm.10458</identifier><identifier>PMID: 12768581</identifier><identifier>CODEN: MRMEEN</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>animal ; Animals ; Biological and medical sciences ; carcinoma ; Contrast Media ; disease models ; Disease Models, Animal ; Gadolinium DTPA ; Magnetic Resonance Imaging ; Medical sciences ; Mice ; Mice, Knockout ; neoplasia ; Stomach - pathology ; stomach neoplasms ; Stomach Neoplasms - diagnosis</subject><ispartof>Magnetic resonance in medicine, 2003-06, Vol.49 (6), p.1033-1036</ispartof><rights>Copyright © 2003 Wiley‐Liss, Inc.</rights><rights>2003 INIST-CNRS</rights><rights>Copyright 2003 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4558-c9c2818ddab2386c8051af900c04abd385e8a58c2f81e314a18ed4c469ab4ddf3</citedby><cites>FETCH-LOGICAL-c4558-c9c2818ddab2386c8051af900c04abd385e8a58c2f81e314a18ed4c469ab4ddf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmrm.10458$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmrm.10458$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14820159$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12768581$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Berr, Stuart S.</creatorcontrib><creatorcontrib>Roche, James K.</creatorcontrib><creatorcontrib>El-Rifai, Wa'el</creatorcontrib><creatorcontrib>Smith Jr, Michael F.</creatorcontrib><creatorcontrib>Powell, Steven M.</creatorcontrib><title>Magnetic resonance imaging of gastric cancer in Tff1 knock-out mice</title><title>Magnetic resonance in medicine</title><addtitle>Magn. Reson. Med</addtitle><description>In this work, the use of MRI to stage gastric neoplasia in a mouse model of spontaneous gastric cancer is demonstrated. The methodology involves 1) the use of deuterated water (2H2O) to distend the stomach, and to provide negative contrast between the stomach and the lumen without inducing susceptibility‐based field shifts; 2) GlucaGen® to minimize motion artifacts that arise from peristalsis; and 3) Gd‐DTPA to enhance contrast between the dysplasia/tumor and the normal wall. Initial images are presented from a Tff1 −/− homozygous knock‐out model of gastric cancer and a heterozygous C57BL6/J control mouse. There are clear differences between the two types of animals in the MR appearance of the stomach. The distended stomach of the control mouse has a smooth perimeter and a thin wall, and an absence of nodules. The stomach of the Tff1 −/− mouse demonstrates a thickened wall; a jagged, irregular surface; and protruding nodules that are bright after injection of Gd‐DTPA. Magn Reson Med 49:1033–1036, 2003. © 2003 Wiley‐Liss, Inc.</description><subject>animal</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>carcinoma</subject><subject>Contrast Media</subject><subject>disease models</subject><subject>Disease Models, Animal</subject><subject>Gadolinium DTPA</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>neoplasia</subject><subject>Stomach - pathology</subject><subject>stomach neoplasms</subject><subject>Stomach Neoplasms - diagnosis</subject><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0EtLKzEUB_AgitbHwi8gs1FwMZrnzMlSqreKrYJUXIY0k5TYeWgyxeu3v_G26kpcJXB-5xzOH6FDgs8IxvS8CU36cAEbaEAEpTkVkm-iAS45zhmRfAftxviMMZay5Ntoh9CyAAFkgIYTPW9t700WbOxa3Rqb-UbPfTvPOpfNdexDKpqPQsh8m02dI9mi7cwi75Z91nhj99GW03W0B-t3Dz3-uZoOr_Px_ehmeDHODRcCciMNBQJVpWeUQWEAC6KdxNhgrmcVA2FBCzDUAbGMcE3AVtzwQuoZryrH9tDJau5L6F6XNvaq8dHYutat7ZZRlYyWEhP2KyQgGWPAEzxdQRO6GIN16iWk68O7Ilh9RKtStOp_tMkerYcuZ42tvuU6ywSO10BHo2sXUmY-fjsOFBMhkztfuTdf2_efN6rJw-Rzdb7q8LG3f786dFioomSlUE93IzWF8eW4GN4qYP8A86Odtg</recordid><startdate>200306</startdate><enddate>200306</enddate><creator>Berr, Stuart S.</creator><creator>Roche, James K.</creator><creator>El-Rifai, Wa'el</creator><creator>Smith Jr, Michael F.</creator><creator>Powell, Steven M.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Williams & Wilkins</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200306</creationdate><title>Magnetic resonance imaging of gastric cancer in Tff1 knock-out mice</title><author>Berr, Stuart S. ; Roche, James K. ; El-Rifai, Wa'el ; Smith Jr, Michael F. ; Powell, Steven M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4558-c9c2818ddab2386c8051af900c04abd385e8a58c2f81e314a18ed4c469ab4ddf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>animal</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>carcinoma</topic><topic>Contrast Media</topic><topic>disease models</topic><topic>Disease Models, Animal</topic><topic>Gadolinium DTPA</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>neoplasia</topic><topic>Stomach - pathology</topic><topic>stomach neoplasms</topic><topic>Stomach Neoplasms - diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Berr, Stuart S.</creatorcontrib><creatorcontrib>Roche, James K.</creatorcontrib><creatorcontrib>El-Rifai, Wa'el</creatorcontrib><creatorcontrib>Smith Jr, Michael F.</creatorcontrib><creatorcontrib>Powell, Steven M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Magnetic resonance in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Berr, Stuart S.</au><au>Roche, James K.</au><au>El-Rifai, Wa'el</au><au>Smith Jr, Michael F.</au><au>Powell, Steven M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Magnetic resonance imaging of gastric cancer in Tff1 knock-out mice</atitle><jtitle>Magnetic resonance in medicine</jtitle><addtitle>Magn. Reson. Med</addtitle><date>2003-06</date><risdate>2003</risdate><volume>49</volume><issue>6</issue><spage>1033</spage><epage>1036</epage><pages>1033-1036</pages><issn>0740-3194</issn><eissn>1522-2594</eissn><coden>MRMEEN</coden><abstract>In this work, the use of MRI to stage gastric neoplasia in a mouse model of spontaneous gastric cancer is demonstrated. The methodology involves 1) the use of deuterated water (2H2O) to distend the stomach, and to provide negative contrast between the stomach and the lumen without inducing susceptibility‐based field shifts; 2) GlucaGen® to minimize motion artifacts that arise from peristalsis; and 3) Gd‐DTPA to enhance contrast between the dysplasia/tumor and the normal wall. Initial images are presented from a Tff1 −/− homozygous knock‐out model of gastric cancer and a heterozygous C57BL6/J control mouse. There are clear differences between the two types of animals in the MR appearance of the stomach. The distended stomach of the control mouse has a smooth perimeter and a thin wall, and an absence of nodules. The stomach of the Tff1 −/− mouse demonstrates a thickened wall; a jagged, irregular surface; and protruding nodules that are bright after injection of Gd‐DTPA. Magn Reson Med 49:1033–1036, 2003. © 2003 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>12768581</pmid><doi>10.1002/mrm.10458</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0740-3194 |
| ispartof | Magnetic resonance in medicine, 2003-06, Vol.49 (6), p.1033-1036 |
| issn | 0740-3194 1522-2594 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73279013 |
| source | Wiley Online Library - AutoHoldings Journals; MEDLINE; Wiley Online Library (Open Access Collection) |
| subjects | animal Animals Biological and medical sciences carcinoma Contrast Media disease models Disease Models, Animal Gadolinium DTPA Magnetic Resonance Imaging Medical sciences Mice Mice, Knockout neoplasia Stomach - pathology stomach neoplasms Stomach Neoplasms - diagnosis |
| title | Magnetic resonance imaging of gastric cancer in Tff1 knock-out mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T10%3A16%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Magnetic%20resonance%20imaging%20of%20gastric%20cancer%20in%20Tff1%20knock-out%20mice&rft.jtitle=Magnetic%20resonance%20in%20medicine&rft.au=Berr,%20Stuart%20S.&rft.date=2003-06&rft.volume=49&rft.issue=6&rft.spage=1033&rft.epage=1036&rft.pages=1033-1036&rft.issn=0740-3194&rft.eissn=1522-2594&rft.coden=MRMEEN&rft_id=info:doi/10.1002/mrm.10458&rft_dat=%3Cproquest_cross%3E73279013%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=18933384&rft_id=info:pmid/12768581&rfr_iscdi=true |