Screening of Tanzanian plant extracts for their potential inhibitory effect on P-glycoprotein mediated efﬂux

For years, many efforts have been made to discover new drugs using plants as natural screening libraries. In this study, extracts of 43 Tanzanian medicinal plants were screened for their potential inhibitory effect on P‐gp, using the secretory transport of Cyclosporin A (CsA) in the Caco‐2 system as...

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Veröffentlicht in:	Phytotherapy research 2003-05, Vol.17 (5), p.459-464
Hauptverfasser:	Deferme, S., Kamuhabwa, A., Nshimo, C., de Witte, P., Augustijns, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acacia Algorithms Annonaceae Antineoplastic Agents, Phytogenic - pharmacology ATP-Binding Cassette, Sub-Family B, Member 1 - physiology Biological and medical sciences Biological Transport - drug effects Caco-2 Cells - drug effects Caco-2 Cells - metabolism Cyclosporine - metabolism Cyclosporins - pharmacology efﬂux General pharmacology Humans inhibition Medical sciences P-glycoprotein Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments plant extract Plant Extracts - pharmacology Tanzania
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